Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: Jan. 31, 2023

Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention

Language: Английский

---

Customizing nano-chitosan for sustainable drug delivery

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 175 - 192

Published: Aug. 19, 2022

Language: Английский

---

Silver and Gold Nanoparticles for Antimicrobial Purposes against Multi-Drug Resistance Bacteria

Materials, Journal Year: 2022, Volume and Issue: 15(5), P. 1799 - 1799

Published: Feb. 27, 2022

Several pieces of research have been done on transition metal nanoparticles and their nanocomplexes as physical chemical properties relationship to biological features are great importance. Among all properties, the antibacterial antimicrobial especially important due high use for human needs. In this article, we will discuss different synthesis modification methods silver (Ag) gold (Au) physicochemical properties. We also review some state-of-art studies find best between nanoparticles’ potential activity. The possible mechanism these types be discussed in-depth well.

Language: Английский

---

Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy

Small, Journal Year: 2021, Volume and Issue: 18(2)

Published: Nov. 5, 2021

Abstract Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards therapeutic target can cause toxic side effects healthy tissues. Here, silver (Ag 2 O NPs) capable controlled reactive oxygen species (ROS) release synthesized. The bactericidal Ag + ions ROS is strictly regulated by external stimuli ultrasound (US) near‐infrared (NIR) light. In vitro vivo investigations show that NPs present enhanced antibacterial antibiofilm capabilities with killing efficiency >99.9999% 10 min, significantly accelerate multi‐drug resistant Staphylococcus aureus infected skin wound closure excellent cytocompatibility hemocompatibility. This work not only provides first paradigm for fabricating nanoparticle but also introduces highly efficient noninvasive safe modality combating infectious diseases.

Language: Английский

---

Switching to nanonutrients for sustaining agroecosystems and environment: the challenges and benefits in moving up from ionic to particle feeding

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 4, 2022

Abstract The worldwide agricultural enterprise is facing immense pressure to intensify feed the world’s increasing population while resources are dwindling. Fertilizers which deemed as indispensable inputs for food, fodder, and fuel production now also represent dark side of intensive food system. With most crop systems focused on quantity produce, indiscriminate use fertilizers has created havoc environment damaged fiber biogeosphere. Deteriorated nutritional quality contribution impaired ecosystem services major limiting factors in further growth fertilizer sector. Nanotechnology agriculture come up a better seemingly sustainable solution meet targets well maintaining environmental by less raw materials active ingredients, increased nutrient use-efficiency plants, decreased losses nutrients. However, nanofertilizers so far been limited largely controlled environments laboratories, greenhouses, institutional research experiments; availability large scale still lagging yet catching fast. Despite perceivable advantages, many times debated adoption at scale. scenario gradually changing, worldwide, towards nanofertilizers, especially macronutrients like nitrogen (e.g. market release nano-urea replace conventional urea South Asia), arrest degradation uphold vital critical condition. This review offers discussion purpose with took shape, benefits can be achieved, challenges face development real-world use, substantiated significant pieces scientific evidence available far. Graphical

Language: Английский

---

Green Synthesis of Magnesium Oxide Nanoparticles and Nanocomposites for Photocatalytic Antimicrobial, Antibiofilm and Antifungal Applications

Catalysts, Journal Year: 2023, Volume and Issue: 13(4), P. 642 - 642

Published: March 23, 2023

Magnesium oxide nanoparticles (MgO NPs) have emerged as potential materials for various biomedical applications due to their unique physicochemical properties, including biodegradability, biocompatibility, cationic capacity, high stability and redox properties. MgO NPs become an attractive platform combat microbes may be a promising alternative overcome challenges associated with eliminating microbial biofilms antibiotic resistance. Hence, the increasing use of in biomedicine, new synthetic strategies are necessary. synthesised using green methods non-toxic, eco-friendly wide range biological, medical catalytic applications. This review presents recent advances biosynthesis by diverse bio-templates, such plant, bacterial, fungal algal extracts. Its photocatalytic properties show suitable inhibitory function against pathogenic agents, proliferation, biofilm formation growth. Furthermore, relevant nanocomposites comprehensively discussed regarding mechanisms effect on microbes, strains, well future perspectives.

Language: Английский

---

Oxygen-Rich Graphene/ZnO2-Ag nanoframeworks with pH-Switchable Catalase/Peroxidase activity as O2 Nanobubble-Self generator for bacterial inactivation

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 637, P. 237 - 250

Published: Jan. 19, 2023

Language: Английский

---

Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

---

Innovative sono-synthesis of cerium dioxide nanomaterials using mentha extract with efficient activity for cancer therapy application

Results in Engineering, Journal Year: 2024, Volume and Issue: 23, P. 102720 - 102720

Published: Aug. 10, 2024

Nanostructured CeO2 was fabricated through a facile sonochemical route utilizing cerium (III) nitrate hexahydrate as metal source and mentha extract novel capping agent. To our knowledge, this experimental work is the first successful endeavor for fabricating nanostructured employing by an easy eco-friendly route. The microstructure various characteristics of oxide nanostructure prepared were investigated using methods. This research examined anticancer effects green synthesized nanoparticles (CeO2-NPs) on cancer cell lines (T98 SHSY5Y) at several concentrations 0.0, 0.05, 0.1, 0.2, 0.4, 0.8 mg/ml NPs exposure time 24/48 h. obtained results presented cytotoxicity against cancerous lines. Considering CeO2-NP's cells indicated significant toxicity lines, these could be applied in medicine developing new drug formulations Additional investigations are desired to reveal other biological applications normal

Language: Английский

---

Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

Nanoscale, Journal Year: 2024, Volume and Issue: 16(7), P. 3324 - 3346

Published: Jan. 1, 2024

POD nanozymes for bactericidal treatment.

Language: Английский

---