2D MOF Periodontitis Photodynamic Ion Therapy

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(37), P. 15427 - 15439

Published: Sept. 13, 2021

Traditional surgical intervention and antibiotic treatment are poor even invalid for chronic diseases including periodontitis induced by diverse oral pathogens, which often causes progressive destruction of tissues, tooth loss, systemic diseases. Herein, an ointment comprising atomic-layer Fe2O3-modified two-dimensional porphyrinic metal–organic framework (2D MOF) nanosheets is designed incorporating a polyethylene glycol matrix. After the atomic layer deposition surface engineering, enhanced photocatalytic activity 2D MOF heterointerface results from lower adsorption energy more charge transfer amounts due to synergistic effect metal–linker bridging units, abundant active sites, excellent light-harvesting network. This biocompatible biodegradable MOF-based heterostructure exhibits broad-spectrum antimicrobial (99.87 ± 0.09%, 99.57 0.21%, 99.03 0.24%) against pathogens (Porphyromonas gingivalis, Fusobacterium nucleatum, Staphylococcus aureus) reactive oxygen species released ions. photodynamic ion therapy superior therapeutic reported clinical owing rapid antibacterial activity, alleviative inflammation, improved angiogenesis.

Language: Английский

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Uranium extraction from seawater: material design, emerging technologies and marine engineering

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 97 - 162

Published: Nov. 30, 2022

Uranium extraction from seawater (UES), a potential approach to securing the long-term uranium supply and sustainability of nuclear energy, has experienced significant progress in past decade.

Language: Английский

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Challenges of photocatalysis and their coping strategies

Chem Catalysis, Journal Year: 2022, Volume and Issue: 2(6), P. 1315 - 1345

Published: May 5, 2022

Language: Английский

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Single-Atom Catalysis for Efficient Sonodynamic Therapy of Methicillin-Resistant Staphylococcus aureus-Infected Osteomyelitis

ACS Nano, Journal Year: 2021, Volume and Issue: 15(6), P. 10628 - 10639

Published: June 4, 2021

Osteomyelitis, as a severe bone disease caused by bacterial infection, can result in lifelong disability or fatal sepsis. Considering that the infection is stubborn and deep-sited tissue, situ rapid treatments for osteomyelitis remain significant challenge. Herein, we prepare an ultrasound (US)-activated single-atom catalyst consists of Au nanorod (NRs)-actuated single-atom-doped porphyrin metal–organic framework (HNTM-Pt@Au) red cell membrane (RBC), which efficiently treat methicillin-resistant Staphylococcus aureus (MRSA)-infected under US. Besides outstanding performance field photocatalysis, find single atoms (such Pt, Au, Cu) also improve sonocatalytic ability sonosensitizer. Due to strong electron-trapping oxygen adsorption capacity, Pt atom endows RBC-HNTM-Pt@Au with excellent activity. It shows antibacterial efficiency 99.9% toward MRSA 15 min US irradiation. Meanwhile, be propelled directionally thus dynamically neutralize secreted toxins. The MRSA-infected rat tibia was successfully treated, negligible loss, reduced inflammation response, great biocompatibility. This work presents efficient sonodynamic therapy treatment deep tissue infections via multifunctional catalyst.

Language: Английский

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Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy

Biomaterials, Journal Year: 2021, Volume and Issue: 275, P. 120918 - 120918

Published: May 25, 2021

Language: Английский

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Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 1346 - 1357

Published: Dec. 27, 2021

Water treatment is crucial to improve the water quality and reduce diarrheal chronological diseases caused by excessive discharge of organic dyes other waste. The development expansion efficient catalysts for degradation sterilization has attracted widespread attention. Herein, we report an example a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) its sono-/photocatalytic bactericidal activity. dislocated layers effectively avoid close π-π stacking provide porous space oxygen/water/dye contact. introduction Zn ions increases spin orbital coupling through heavy atom effect promotes intersystem crossing process singlet oxygen generation. effective ligand-to-metal charge transfer open catalytic sites also facilitate splitting hydroxyl radical These features together promote reactive species (ROS) generation 2DZnTcpp under light illumination or ultrasound sonication. It worth noting that with high specific surface area porosity shows dye Moreover, could largely inactivate Escherichia coli irradiation (the power 1 sun) sonication 30 min efficiencies over 99.99999%. This work provides approach design synthesis MOF-based sono-/photocatalysts used in purification textile wastewater committed establishment more efficient, fast, environmentally friendly system.

Language: Английский

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Photodynamic and photothermal co-driven CO-enhanced multi-mode synergistic antibacterial nanoplatform to effectively fight against biofilm infections

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 426, P. 131919 - 131919

Published: Aug. 21, 2021

Language: Английский

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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

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Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(9), P. 2609 - 2644

Published: July 21, 2021

Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes, in contrast to conventional chemotherapeutic drugs, which act on precise targets such as DNA specific enzymes. Owing their rapid action, broad-spectrum activity, and mechanisms action potentially hinder development resistance, MDPs have been increasingly considered future therapeutics drug-resistant era. Recently, growing experimental evidence has demonstrated can also be utilized adjuvants enhance therapeutic effects other agents. In this review, we evaluate literature around antimicrobial properties anticancer activity MDPs, summarize current alone combination with Notably, review highlights recent advances design various MDP-based drug delivery systems improve effect minimize side effects, promote co-delivery multiple chemotherapeutics, for more efficient therapy.

Language: Английский

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Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 157 - 174

Published: Aug. 21, 2022

Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain most severe concern due prevalence emergence multi-drug resistance (MDR) limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is potential modality that involves systematic administration photosensitizers (PSs), light, molecular oxygen (O2) for coping infections. Although porphyrin non-porphyrin PSs were effective in APDT, poor solubility, limited efficacy against Gram-negative bacteria, non-specific distribution hinder their clinical applications. Accordingly, promote efficiency conventional PSs, various polymer-driven modification functionalization strategies have been adopted engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements state-of-the-art research polymer-PSs materials developed APDT Further, key findings following aspects are considered in-depth constructive discussions: i) PSs-integrated/functionalized polymeric composites through interactions; ii) PSs-deposited coatings on different substrates devices eliminate healthcare-associated infections; iii) PSs-embedded films, scaffolds, hydrogels regenerative medicine

Language: Английский

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