Targeted delivery of nanomedicines to glioblastoma: Overcoming the clinical barrier DOI Creative Commons
Aadya Nayak, Neerada Meenakshi Warrier,

Rachana Raman

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105980 - 105980

Published: July 16, 2024

The current standard therapy for GBM includes maximal surgical resection, followed by concurrent radiotherapy and oral chemotherapy; however, the median post-diagnosis survival period is only 15–18 months. Nanoparticles (NPs) their composite drug delivery systems (DDSs)—particularly those with liposomes polymeric nanoparticles (PNPs)—have become an increasingly popular route therapeutic in glioblastoma multiforme (GBM). These also have added benefit of enabling combinational therapies, which particularly necessary more resilient cancers like GBM. To ensure most effective means targeting tumor microenvironment (TME), stem cells (GSCs) can be used, both as targets vectors—both avenues showing promising results. However, DDSs directed towards brain must overcome many barriers associated cranial administration—including blood-brain-barrier (BBB) its derivatives, intracranial fluid pressure, induced regression from NP activating protocols involving heat or electromagnetic radiation, extended retention synthetic within tissue—before they finally circulate clinical domain. In this article, we review progress made incorporating GSCs design, well challenges that need to addressed facilitate a widespread regimen successfully treating

Language: Английский

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics DOI Creative Commons
Harshita Tiwari, Nilesh Rai, Swati Singh

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(7), P. 760 - 760

Published: June 25, 2023

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis treatment. Nanomaterials are extensively employed the field oncology because their minute size ultra-specificity. A wide range nanocarriers, such as dendrimers, micelles, PEGylated liposomes, polymeric nanoparticles used to facilitate efficient transport anti-cancer drugs at target tumor site. Real-time labeling monitoring cells quantum dots essential for determining level therapy needed The drug targeted site either by passive or active means. Passive targeting makes use microenvironment enhanced permeability retention effect, while involves ligand-coated nanoparticles. Nanotechnology being diagnose early stage detecting cancer-specific biomarkers imaging. implication employs photoinduced nanosensitizers, reverse multidrug resistance, enabling delivery CRISPR/Cas9 RNA molecules therapeutic applications. However, despite recent advancements nano-oncology, there need delve deeper into domain designing applying improved diagnostics.

Language: Английский

Citations

74
Nanoparticle-based drug delivery systems targeting cancer cell surfaces DOI Creative Commons

Liquan Hong,

Wen Li, Yang Li

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(31), P. 21365 - 21382

Published: Jan. 1, 2023

This review focuses on the research progress of various receptors overexpressed surface cancer cells and different nano-delivery systems anticancer drugs targeted cells.

Language: Английский

Citations

71
Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates DOI Open Access
Tarun Virmani, Girish Kumar, Ashwani Sharma

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(13), P. 2928 - 2928

Published: July 1, 2023

The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.

Language: Английский

Citations

51
Synthesis and Bioapplication of Emerging Nanomaterials of Hafnium DOI
David Skrodzki, Matthew Molinaro, Richard S. Brown

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1289 - 1324

Published: Jan. 2, 2024

A significant amount of progress in nanotechnology has been made due to the development engineered nanoparticles. The use metallic nanoparticles for various biomedical applications extensively investigated. Biomedical research is highly focused on them because their inert nature, nanoscale structure, and similar size many biological molecules. intrinsic characteristics these particles, including electronic, optical, physicochemical, surface plasmon resonance, that can be altered by altering size, shape, environment, aspect ratio, ease synthesis, functionalization properties, have led numerous applications. Targeted drug delivery, sensing, photothermal photodynamic therapy, imaging are some these. promising clinical results NBTXR3, a high-Z radiosensitizing nanomaterial derived from hafnium, demonstrated translational potential this metal. This radiosensitization approach leverages dependence energy attenuation atomic number enhance energy-matter interactions conducive radiation therapy. High-Z nanoparticle localization tumor issue differentially increases effect ionizing cancer cells versus nearby healthy ones mitigates adverse effects reducing overall burden. principle enables material multifunctionality as contrast agents X-ray-based imaging. physiochemical properties hafnium (Z = 72) particularly advantageous well-placed K-edge absorption high mass coefficient compared elements human tissue across ranges leads attenuation. Chemical reactivity allows variety composition, functionalization. Nanoparticles such oxide exhibit excellent biocompatibility inertness prior incidence with radiation. Additionally, optical electronic applicable biosensing, component coatings, semiconductors. wide interest prompted extensive design synthesis facilitate property fine-tuning. review summarizes synthetic methods hafnium-based nanomaterials imaging, biosensing mechanistic focus. discussion future perspective section highlights elaborates current challenges. By focusing factors impacting applicational effectiveness examining limitations aims support researchers expedite translation nanomedicine.

Language: Английский

Citations

20
New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

5
Nanoparticles in Medicine: Current Status in Cancer Treatment DOI Open Access
Krešimir Pavelić, Sandra Kraljević Pavelić, Aleksandar Bulog

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12827 - 12827

Published: Aug. 15, 2023

Cancer is still a leading cause of deaths worldwide, especially due to those cases diagnosed at late stages with metastases that are considered untreatable and managed in such way lengthy chronic state achieved. Nanotechnology has been acknowledged as one possible solution improve existing cancer treatments, but also an innovative approach developing new therapeutic solutions will lower systemic toxicity increase targeted action on tumors metastatic tumor cells. In particular, the nanoparticles studied context treatment include organic inorganic particles whose role may often be expanded into diagnostic applications. Some best metallic gold silver nanoparticles, quantum dots, polymeric carbon nanotubes graphene, diverse mechanisms as, for example, increased induction reactive oxygen species, cellular uptake functionalization properties improved delivery. Recently, novel cell targeting nanobubbles, which have already demonstrated localization anticancer molecules tissues. this review, we accordingly present discuss state-of-the-art nano-formulations limitations their application clinical setting.

Language: Английский

Citations

38
Nanomedicine as a multimodal therapeutic paradigm against cancer: on the way forward in advancing precision therapy DOI
Puja Sandbhor, Pranoti Palkar, Sakshi Bhat

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(13), P. 6330 - 6364

Published: Jan. 1, 2024

Graphical representation of recent advancements in combinatorial anticancer treatment modalities.

Language: Английский

Citations

18
Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models DOI Creative Commons
Hossein Abolhassani,

Alireza Eskandari,

Anita Saremi Poor

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215754 - 215754

Published: March 12, 2024

The science of nanotechnology has been proposed as a factor main change in the field cancer diagnosis and treatment. challenges common clinical treatment breast can be dominate by proof targeting cells nanoscale drug delivery system. Due to specific properties nanoparticles such biocompatibility, minimum toxicity, excellent stability, multifunctional encapsulations therapeutic agents, increased permeability retention effect, selective targeting, they apply for therapy. Multidrug resistance many chemotherapy drugs is one conventional that overcome nanoparticles. However, vivo vitro studies limited this field, number approved nano formulation not significantly over years. Successful translation nanomedicines arduous requiring considerable preclinical tests. Two-dimensional (2D) monolayer cell cultures animal models, which are routinely used research discovery/screening seem inadequate. To address challenge, biomimetic three-dimensional (3D) tumor models like spheroids, organoids, scaffolds/hydrogels, bioprinted, microfluidic chips have established using engineering approach. Taking physiopathology microenvironment into account, potential enhance disease modeling drug/nanomedicine screening. development 3D comprised patient's own cancer, stromal, immune exploited promising platform provide personalized

Language: Английский

Citations

17
Paclitaxel for breast cancer therapy: A review on effective drug combination modalities and nano drug delivery platforms DOI

Masoumeh Kaveh Zenjanab,

Sajjad Alimohammadvand, Abolfazl Doustmihan

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105567 - 105567

Published: March 19, 2024

Language: Английский

Citations

17
Nanoscale strides: exploring innovative therapies for breast cancer treatment DOI Creative Commons
Sruthi Laakshmi Mugundhan, M. Mothilal

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14017 - 14040

Published: Jan. 1, 2024

Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential superiority over conventional methods, transforming management.

Language: Английский

Citations

13