Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(27)
Published: April 7, 2022
Abstract
Bacterial
infection
and
excessive
inflammation
following
abdominal
injury
can
cause
life‐threatening
complications
that
lead
to
multiple
organ
failure
death.
Removing
bacteria
proinflammatory
factors—which
are
predominantly
negatively
charged—from
the
wound
site
with
a
cationic,
antibiotic‐containing
hydrogel
dressing
is
therefore
promising
treatment
approach
for
severe
trauma.
Here
an
injectable,
self‐healing
composed
of
gel‐forming
glycosaminoglycan
oxidized
chondroitin
sulfate
(OCS),
cationic
polyethylenimine
(PEI),
antibiotic
tobramycin
(Tob)
via
Schiff's
base
reaction
developed.
Compared
hydrogels
lacking
either
PEI
or
Tob,
only
Tob/PEI/OCS
exhibit
large
binding
capacity
negatively‐charged
factors
including
cell‐free
DNA,
lipopolysaccharides,
TNF‐α,
high
mobility
group
box
1
protein,
reduction
in
bacterial
populations
vitro.
In
murine
model
trauma,
exhibits
good
biodegradability
biosafety,
reduced
local
systemic
infection,
prevents
failure,
resulting
100%
survival.
This
thus
biomaterial
preventing
improving
outcomes
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(5), P. 5068 - 5143
Published: Dec. 28, 2021
Recent
advances
in
nanostructured
materials
and
unconventional
device
designs
have
transformed
the
bioelectronics
from
a
rigid
bulky
form
into
soft
ultrathin
brought
enormous
advantages
to
bioelectronics.
For
example,
mechanical
deformability
of
thus
its
conformal
contact
onto
curved
organs
such
as
brain,
heart,
skin
allowed
researchers
measure
high-quality
biosignals,
deliver
real-time
feedback
treatments,
lower
long-term
side-effects
vivo.
Here,
we
review
various
materials,
fabrication
methods,
strategies
for
flexible
stretchable
electronics,
especially
focusing
on
biointegrated
electronics
using
nanomaterials
their
composites.
First,
summarize
top-down
material
processing
bottom-up
synthesis
methods
nanomaterials.
Next,
discuss
state-of-the-art
technologies
intrinsically
nanocomposites
composed
incorporated
elastomers
or
hydrogels.
We
also
briefly
design
Then
individual
components
bioelectronics,
biosensing,
data
storage,
display,
therapeutic
stimulation,
power
supply
devices,
are
introduced.
Afterward,
representative
application
examples
described.
A
brief
summary
with
discussion
remaining
challenges
concludes
review.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(34)
Published: Aug. 23, 2023
Although
membrane
technology
has
attracted
considerable
attention
for
oily
wastewater
treatment,
the
plastic
waste
generated
from
discarded
membranes
presents
an
immediate
challenge
achieving
eco-friendly
separation.
We
designed
on-demand
biodegradable
superhydrophilic
composed
of
polylactic
acid
nanofibers
in
conjunction
with
polyethylene
oxide
hydrogels
using
electrospinning
ultrafast
purification
water.
Our
results
showed
that
use
increased
number
hydrogen
bonds
formed
between
surface
and
water
molecules
by
357.6%.
This
converted
hydrophobic
into
ones,
which
prevented
fouling
accelerated
emulsion
penetration
through
membranes.
The
oil-in-water
permeance
our
newly
nanofiber
61.9
times
(2.1
×
104
liters
per
square
meter
hour
bar)
separation
efficiency
>99.6%,
was
superior
to
state-of-the-art
Moreover,
formation
found
accelerate
biodegradation
lactic
over
30%,
offering
a
promising
approach
treatment.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(10), P. 3926 - 3963
Published: Jan. 1, 2022
The
combination
of
plasmonic
nanomaterials
with
responsive
polymer
hydrogels
yields
novel
materials
and
devices
exceptional
synergetic
properties,
which
are
reviewed
in
the
context
applications,
such
as
sensing
actuation.
