Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases DOI Creative Commons
Yohan Han, Yin Zhu, Hannah Youngblood

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 556 - 569

Published: Nov. 3, 2022

Language: Английский

Research progress in membrane fusion-based hybrid exosomes for drug delivery systems DOI Creative Commons
Anqi Liu, Gang Yang, Yuehua Liu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 16, 2022

Liposomes are the earliest and most widely used nanoparticles for targeted drug delivery. Exosomes nanosized membrane-bound particles important mediators of intercellular communication. Combining liposomes exosomes using various membrane fusion methods gives rise to a novel potential delivery system called fusion-based hybrid (MFHE). These MFHEs not only exhibit advantageous features, such as high loading rate cellular uptake via surface modification, but also endowed with biocompatibility low immunogenicity. Here, we provide an overview MFHEs’ preparation methods, characterization strategies, their applications disease treatment scientific research.

Language: Английский

Citations

58
Exosome-based drug delivery systems and their therapeutic applications DOI Creative Commons
Jae‐Wook Lee,

Ji-Heon Lee,

Kushal Chakraborty

et al.

RSC Advances, Journal Year: 2022, Volume and Issue: 12(29), P. 18475 - 18492

Published: Jan. 1, 2022

In the past few decades, scientists have actively worked on developing effective drug delivery systems (DDSs) as means to control life-threatening diseases and challenging illnesses.

Language: Английский

Citations

48
Extracellular vesicles as next generation immunotherapeutics DOI
David W. Greening, Rong Xu,

Anukreity Ale

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 90, P. 73 - 100

Published: Feb. 10, 2023

Language: Английский

Citations

41
Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery DOI Creative Commons

Diego Andrés Rodríguez,

Pieter Vader

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 267 - 267

Published: Jan. 23, 2022

The continuous technological advancement of nanomedicine has enabled the development novel vehicles for effective delivery therapeutic substances. Synthetic drug systems are nano-sized carriers made from various materials that can be designed to deliver cargoes cells or tissues. However, rapid clearance by immune system and poor targeting profile synthetic examples pressing obstacles faced in nanomedicine, which have directed field toward alternative strategies. Extracellular vesicles (EVs) nanoscale particles enclosed a protein-rich lipid bilayer; they released considered important mediators intercellular communication. Owing their natural composition, EVs been suggested exhibit good biocompatibility possess homing properties specific cell types. Combining with nanoparticles defined hybridization steps gives rise potential tool, i.e., EV-based hybrid systems. These advantageous features as compared such enhanced cellular uptake cargo delivery, immuno-evasive properties, capability crossing biological barriers, tissue profile. Here, we provide an overview strategies practiced produce elucidate those obtained upon EVs.

Language: Английский

Citations

40
Nebulization of extracellular vesicles: A promising small RNA delivery approach for lung diseases DOI Creative Commons
Yohan Han, Yin Zhu, Hannah Youngblood

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 556 - 569

Published: Nov. 3, 2022

Language: Английский

Citations

40