Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties DOI Creative Commons
Xiaolei Guo, Xin Zhao, Yuan Lei

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 13, 2024

Abstract Underwater adhesives with injectable, organic solvent‐free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post‐cure reaction of isocyanate esterification without solvents. The PUWA created through injectable two component curing process A (biocompatible prepolymer) B (dopamine modified lysine derivatives: chain extender‐LDA crosslinker‐L 3 DA). two‐component cures quickly firmly underwater, impressive bonding strength 40 kPa on pork skin excellent burst pressure 394 mmHg. Moreover, exhibits robust adhesion hostile environments acid, alkali saline solutions. Combined biocompatibility performance, demonstrates effectively sealing wounds promoting healing. With ability to bond diverse substrates rapidly strongly, holds significant potential for application both industrial fields.

Language: Английский

Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing DOI
Jiahui He, Zhenlong Li,

Jiaxin Wang

et al.

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 110985 - 110985

Published: Sept. 9, 2023

Language: Английский

Citations

84
Conductive hydrogels for tissue repair DOI Creative Commons
Yongping Liang, Lipeng Qiao,

Bowen Qiao

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(12), P. 3091 - 3116

Published: Jan. 1, 2023

This work reviewed the new progress of conductive hydrogels in application tissue repair and provided a useful reference for further preparation safer more efficient engineering.

Language: Английский

Citations

81
Antibacterial Electrospun Nanofibrous Materials for Wound Healing DOI
Zijian Wang, Weikang Hu, Wang Wang

et al.

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 5(1), P. 107 - 129

Published: Nov. 2, 2022

Language: Английский

Citations

78
Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review DOI Creative Commons
Jiahao Yang, Shige Wang

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 138 - 138

Published: Feb. 6, 2023

Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, remodeling stages. In order to realize comprehensive systematic wound management, appropriate treatment bio-adhesives are urgently needed. Hydrogel have excellent properties show unique remarkable advantages in the field of management. This review begins with detailed description design criteria functionalities ideal hydrogel for healing. Then, recent advances polysaccharide-based multifunctional bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, other polysaccharides, comprehensively discussed. Finally, current challenges future research directions proposed stimulate further exploration by researchers.

Language: Английский

Citations

78
Injectable Self-Healing Adhesive Natural Glycyrrhizic Acid Bioactive Hydrogel for Bacteria-Infected Wound Healing DOI
Qing Li, Shiqi Zhang,

Ruijie Du

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17562 - 17576

Published: March 6, 2023

Bioactive hydrogels self-assembled from naturally occurring herbal small molecules are attracting growing interest for applications in wound healing, due to their versatile intrinsic biological activities, excellent biocompatibility, as well facile, sustainable, and eco-friendly processes. However, the development of supramolecular herb with sufficient strength multifunctionality an ideal dressing clinical practice remains a challenge. In this work, inspired by efficient clinic therapy directed self-assembly natural saponin glycyrrhizic acid (GA), we create novel GA-based hybrid hydrogel promote full-thickness healing bacterial-infected healing. This possesses stability mechanical performance multifunctional properties, including injectable, shape-adaptation remodeling, self-healing, adhesive abilities. is attributed hierarchical dual-network that comprises hydrogen-bond fibrillar network aldehyde-contained GA (AGA) dynamic covalent through Schiff base reaction between AGA biopolymer carboxymethyl chitosan (CMC). Notably, benefiting inherent strong activity GA, AGA-CMC exhibits unique significant anti-inflammation effects antibacterial ability, especially toward Gram-positive Staphylococcus aureus (S. aureus). vivo experiments demonstrate promotes uninfected skin S. aureus-infected enhancing formation granulation tissue, facilitating collagen deposition, reducing bacterial infection, downregulating inflammatory response. study highlights design new bioactive drug-food homologous molecules, which can serve promising wound-healing biomedical applications.

Language: Английский

Citations

72
Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management DOI
Xin Zhao, Ying Huang, Zhenlong Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(15)

Published: Nov. 16, 2023

Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand stop lethal and/or noncompressible in civil battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, self-propelling hydrogel bioadhesive with procoagulant activity rapid gelation is reported. This combines spontaneous gas foaming Schiff base crosslinking for massive hemorrhage. Hydrogels have expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, tissue adhesion capacity. In addition, good cytocompatibility, ability, higher blood cell/platelet than commercial combat gauze gelatin sponge. The optimized (OD-C/QGQL-A30) exhibits better hemostatic ability sponge rat liver femoral artery models, rabbit volumetric loss models with/without anticoagulant, kidney incision site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, swine subclavian vein transection. Furthermore, has biodegradability biocompatibility, accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. opens up new avenue develop hemostats bleeding, abdominal organ coagulation lesions.

Language: Английский

Citations

70
Smart wound dressing for advanced wound management: Real-time monitoring and on-demand treatment DOI Creative Commons
Qian Pang, Fang Yang,

Zilian Jiang

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111917 - 111917

Published: April 7, 2023

Timely and accurate assessment of wounds during the wound healing process is key for correct diagnosis treatment decisions repair. However, traditional management strategies often fail to provide timely information on status, thereby delaying or misleading treatments. Smart dressings that enable in situ real-time monitoring wound-related biomarkers, early on-demand adverse events, such as bacterial infection inflammation, by integrating wearable sensors, advanced drug delivery systems wireless communication technology have recently been developed could improve management. In this review, we provided an overview including temperature, pH, uric acid, glucose, reactive oxygen (ROS), enzymes, related events exiting sensors detecting these biomarkers based colorimetric, fluorimetric electrochemical approaches. Examples smart integrate controllable functions triggered both endogenous exogenous stimuli, all-in-one dressing capable treatment, major challenges exciting opportunities are presented comprehensively discussed.

Language: Английский

Citations

67
Chitosan-based self-healing hydrogel dressing for wound healing DOI
Xingyu Zhang, Yongping Liang,

Shengfei Huang

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103267 - 103267

Published: Aug. 3, 2024

Language: Английский

Citations

63
Supramolecular hydrogels for wound repair and hemostasis DOI

Shaowen Zhuo,

Yongping Liang,

Zhengying Wu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 37 - 101

Published: Oct. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Language: Английский

Citations

51
Anti‐Dehydration and Rapid Trigger‐Detachable Multifunctional Hydrogels Promote Scarless Therapeutics of Deep Burn DOI
Heng An, Meng Zhang, Liping Zhou

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(17)

Published: Feb. 1, 2023

Abstract There are issues and challenges in treating deep burns because of the long recovery time, frequent dressing changes, wound infection, easy to form scar that influence aesthetics. Besides, some specific tissues not suitable for large coverage (e.g., face, perineum). Therefore, an ideal burn should have good adhesion properties fit effectively, painless quick replacement, resistant accelerate healing, reduce scarring facilitate monitoring diagnosis. Herein, anti‐dehydration rapid‐trigger multifunctional hydrogel is prepared by interface reaction. The Pacrylamide‐Formylboronicacid‐Tannic acid (PAFT) hydrogels a simple method on elastomeric membrane, which obtained using tannic as dynamic cross‐linking agent with 3‐formylboronic acrylamideunder UV light. exhibits strong interfacial (892 J m −2 ± 65 ), rapidly (2 min) decreases (to 180 20 ) when presence glucose solution. has excellent moisturizing properties, also superior antibacterial hemostasis, biocompatibility. This transparent allowing effective observation transformation therapeutics. Moreover, PAFT accelerates healing reduces scars.

Language: Английский

Citations

42