Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829

Published: June 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Language: Английский

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Recent Advances in Superhydrophobic and Antibacterial Cellulose-Based Fibers and Fabrics: Bio-inspiration, Strategies, and Applications

Advanced Fiber Materials, Journal Year: 2023, Volume and Issue: 5(5), P. 1555 - 1591

Published: May 22, 2023

Language: Английский

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Emerging Bioprinting for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Language: Английский

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Double-network cellulose-based hybrid hydrogels with favourable biocompatibility and antibacterial activity for wound healing

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 319, P. 121193 - 121193

Published: July 11, 2023

Language: Английский

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CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007

Published: April 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Language: Английский

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Electrospun organic/inorganic hybrid nanofibers for accelerating wound healing: a review

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3171 - 3190

Published: Jan. 1, 2024

This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.

Language: Английский

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Photothermal microneedle patch loaded with antimicrobial peptide/MnO2 hybrid nanoparticles for chronic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148938 - 148938

Published: Jan. 21, 2024

Language: Английский

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Electrospinning/3D printing drug-loaded antibacterial polycaprolactone nanofiber/sodium alginate-gelatin hydrogel bilayer scaffold for skin wound repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 129705 - 129705

Published: Jan. 23, 2024

Language: Английский

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Recent Advances in Functional Cellulose-Based Materials: Classification, Properties, and Applications

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(5), P. 1343 - 1368

Published: June 26, 2024

Language: Английский

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Highly Bioactive MXene-M2-Exosome Nanocomposites Promote Angiogenic Diabetic Wound Repair through Reconstructing High Glucose-Derived Immune Inhibition

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4269 - 4286

Published: Jan. 25, 2024

The repair of diabetic wounds remains challenging, primarily due to the high-glucose-derived immune inhibition which often leads excessive inflammatory response, impaired angiogenesis, and heightened susceptibility infection. However, means reduce immunosuppression regulate conversion M2 phenotype macrophages under a high-glucose microenvironment using advanced biomaterials for are not yet fully understood. Herein, we report two-dimensional carbide (MXene)-M2 macrophage exosome (Exo) nanohybrids (FM-Exo) promoting wound by overcoming inhibition. FM-Exo showed sustained release macrophage-derived exosomes (M2-Exo) up 7 days exhibited broad-spectrum antibacterial activity. In microenvironment, relative single Exo, could significantly induce optimized M2a/M2c polarization ratio activating PI3K/Akt signaling pathway, proliferation, migration fibroblasts, angiogenic ability endothelial cells. full-thickness model, effectively regulated status promoted their transition phenotype, thereby inhibiting inflammation, angiogenesis through VEGF secretion, improving proper collagen deposition. As result, healing process was accelerated, leading better outcome with reduced scarring. Therefore, this study introduced promising approach address developing bioactive nanomaterials in environment.

Language: Английский

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