Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 23, 2024
Chronic
wound
management
is
an
intractable
medical
and
social
problem,
affecting
the
health
of
millions
worldwide.
Decellularized
extracellular
matrix
(dECM)-based
materials
possess
remarkable
biological
properties
for
tissue
regeneration,
which
have
been
used
as
commercial
products
skin
regeneration
in
clinics.
However,
complex
external
environment
longer
chronic
wound-healing
process
hinder
application
pure
dECM
materials.
dECM-based
composite
are
constructed
to
promote
healing
different
wounds,
showing
noteworthy
functions,
such
anti-microbial
activity
suitable
degradability.
Moreover,
fabrication
technologies
designing
dressings
with
various
forms
expanded
This
review
provides
a
summary
recent
building
materials,
highlighting
advances
molded
hydrogels,
electrospun
fibers,
bio-printed
scaffolds
managing
wounds.
The
associated
challenges
prospects
clinical
finally
discussed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 11, 2023
Bioprinting
has
attracted
much
attention
due
to
its
suitability
for
fabricating
biomedical
devices.
In
particular,
bioprinting
become
one
of
the
growing
centers
in
field
wound
healing,
with
various
types
bioprinted
devices
being
developed,
including
3D
scaffolds,
microneedle
patches,
and
flexible
electronics.
Bioprinted
can
be
designed
specific
biostructures
biofunctions
that
closely
match
shape
sites
accelerate
regeneration
skin
through
approaches.
Herein,
a
comprehensive
review
smart
dressings
is
presented,
emphasizing
crucial
effect
determining
biofunctions.
The
begins
an
overview
techniques
devices,
followed
in-depth
discussion
polymer-based
inks,
modification
strategies,
additive
ingredients,
properties,
applications.
strategies
are
divided
into
seven
categories,
chemical
synthesis
novel
physical
blending,
coaxial
bioprinting,
multimaterial
absorption,
immobilization,
hybridization
living
cells,
examples
presented.
Thereafter,
frontiers
4D
artificial
intelligence-assisted
situ
discussed
from
perspective
interdisciplinary
sciences.
Finally,
current
challenges
future
prospects
this
highlighted.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10998 - 11007
Published: April 29, 2024
Infections
caused
by
bacteria
pose
a
serious
threat
to
public
health,
and
there
is
need
for
numerous
innovative,
antibiotic-free
antimicrobial
medicines.
Herein,
we
describe
the
synthesis
of
CuS/Co-ferrocene-MOF
(CuS/Co-Fc-MOF)
nanocomposites,
formed
coupling
CuS
nanoparticles
(NPs)
two-dimensional
(2D)
Co-Fc-MOF
nanosheets,
that
constitutes
an
platform
capable
near-infrared
(NIR)
photothermal
promotion
chemodynamic
antibacterial.
2D
CuS/Co-Fc-MOF
nanocomposites
consist
nanosheets
with
dimensions
approximately
100–200
nm
thicknesses
13.1–15.6
nm,
where
NPs,
size
about
8
are
excellently
dispersed
on
surface
nanosheets.
The
diverse
valence
states
cobalt
iron
in
enable
them
undergo
Fenton-like
reactions
H2O2,
thus
generating
highly
oxidizing
·OH
therapy
(CDT).
utilization
local
plasmonic
resonance
effect
NPs
enables
enhancement
CDT
activity
under
laser
irradiation.
More
importantly,
can
achieve
rapid
(15
min)
NIR
laser-assisted
killing
both
S.
aureus
E.
coli
bacterial
infection
microenvironment
compared
Therefore,
be
employed
as
promising
nanoagent
promote
photothermally
augmented
antibacterial
therapy.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(13), P. 3171 - 3190
Published: Jan. 1, 2024
This
review
summarizes
fabrication
strategies
and
manifold
applications
of
electrospun
organic/inorganic
hybrid
nanofibers
in
promoting
the
wound
healing
process.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 4269 - 4286
Published: Jan. 25, 2024
The
repair
of
diabetic
wounds
remains
challenging,
primarily
due
to
the
high-glucose-derived
immune
inhibition
which
often
leads
excessive
inflammatory
response,
impaired
angiogenesis,
and
heightened
susceptibility
infection.
However,
means
reduce
immunosuppression
regulate
conversion
M2
phenotype
macrophages
under
a
high-glucose
microenvironment
using
advanced
biomaterials
for
are
not
yet
fully
understood.
Herein,
we
report
two-dimensional
carbide
(MXene)-M2
macrophage
exosome
(Exo)
nanohybrids
(FM-Exo)
promoting
wound
by
overcoming
inhibition.
FM-Exo
showed
sustained
release
macrophage-derived
exosomes
(M2-Exo)
up
7
days
exhibited
broad-spectrum
antibacterial
activity.
In
microenvironment,
relative
single
Exo,
could
significantly
induce
optimized
M2a/M2c
polarization
ratio
activating
PI3K/Akt
signaling
pathway,
proliferation,
migration
fibroblasts,
angiogenic
ability
endothelial
cells.
full-thickness
model,
effectively
regulated
status
promoted
their
transition
phenotype,
thereby
inhibiting
inflammation,
angiogenesis
through
VEGF
secretion,
improving
proper
collagen
deposition.
As
result,
healing
process
was
accelerated,
leading
better
outcome
with
reduced
scarring.
Therefore,
this
study
introduced
promising
approach
address
developing
bioactive
nanomaterials
in
environment.
