International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
677, P. 125640 - 125640
Published: April 24, 2025
Multiple
chemotherapeutic
strategies
have
been
developed
to
tackle
the
complexity
of
cancer.
Still,
outcome
regimens
remains
impaired
by
drugs'
weak
solubility,
unspecific
biodistribution
and
poor
tumor
accumulation
after
systemic
administration.
Such
constraints
triggered
development
nanomaterials
encapsulate
deliver
anticancer
drugs.
In
fact,
loading
drugs
into
nanoparticles
can
overcome
most
solubility
concerns.
However,
ability
systemically
administered
drug-loaded
reach
site
has
vastly
overestimated,
limiting
their
clinical
translation.
The
nanomaterials'
administration
issues
propelled
hydrogels
capable
performing
direct/local
delivery
site.
use
these
macroscale
systems
mediate
a
tumor-confined
drugs/drugs-loaded
grants
an
improved
therapeutic
efficacy
and,
simultaneously,
reduction
side
effects.
manufacture
requires
careful
selection
tailoring
specific
polymers/materials
as
well
choice
appropriate
physical
and/or
chemical
crosslinking
interactions.
Depending
on
route
assembling
process,
matrices
be
classified
injectable
in
situ
forming
hydrogels,
shear-thinning/self-healing
implantable
each
type
bringing
plethora
advantages
for
intended
biomedical
application.
This
review
provides
reader
with
insight
application
nanomaterials.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(10)
Published: Jan. 30, 2023
Granular
hydrogels
are
an
emerging
class
of
biomaterials
formed
by
jamming
hydrogel
microparticles
(i.e.,
microgels).
These
materials
have
many
advantageous
properties
that
can
be
tailored
through
microgel
design
and
extent
packing.
To
enhance
the
range
properties,
granular
composites
with
a
interstitial
matrix
between
packed
microgels,
allowing
for
material
flow
then
stabilization
after
crosslinking.
This
approach
allows
distinct
compartments
microgels
space)
varied
to
engineer
complex
behaviors.
However,
thorough
investigation
how
compositions
ratios
matrices
influence
has
not
been
performed.
Herein,
fabricated
combining
fragmented
hyaluronic
acid
(HA)
consisting
photocrosslinkable
HA.
Microgels
varying
compressive
moduli
(10-70
kPa)
combined
(0-30
vol.%)
from
2-120
kPa.
composite
structure
(confocal
imaging),
mechanics
(local
bulk),
behavior
(rheology),
printability
thoroughly
assessed.
Lastly,
variations
in
chemistry
(covalent
vs
guest-host)
degradability
investigated.
Overall,
this
study
describes
composition
on
mechanical
towards
informed
designs
future
applications.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
487, P. 150403 - 150403
Published: March 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(4), P. 103936 - 103936
Published: Feb. 29, 2024
This
review
highlights
the
transformative
impact
of
microfluidic
technology
on
personalized
drug
delivery.
Microfluidics
addresses
issues
in
traditional
synthesis,
providing
precise
control
and
scalability
nanoparticle
fabrication,
platforms
show
high
potential
for
versatility,
offering
patient-specific
dosing
real-time
monitoring
capabilities,
all
integrated
into
wearable
technology.
Covalent
conjugation
antibodies
to
nanoparticles
improves
bioactivity,
driving
innovations
targeting.
The
integration
microfluidics
with
sensor
technologies
artificial
intelligence
facilitates
feedback
autonomous
adaptation
delivery
systems.
Key
challenges,
such
as
droplet
polydispersity
fluidic
handling,
along
future
directions
focusing
reliability,
are
essential
considerations
advancing
Advanced Healthcare Materials,
Journal Year:
2022,
Volume and Issue:
11(16)
Published: June 9, 2022
Micrometer-sized
hydrogels
are
cross-linked
three-dimensional
network
matrices
with
high-water
contents
and
dimensions
ranging
from
several
to
hundreds
of
micrometers.
Due
their
excellent
biocompatibility
capability
mimic
physiological
microenvironments
in
vivo,
micrometer-sized
have
attracted
much
attention
the
biomedical
engineering
field.
Their
biological
properties
applications
primarily
influenced
by
chemical
compositions
geometries.
However,
inhomogeneous
morphologies
uncontrollable
geometries
limit
traditional
obtained
bulk
mixing.
In
contrast,
microfluidic
technology
holds
great
potential
for
fabrication
since
geometries,
sizes,
structures,
compositions,
physicochemical
can
be
precisely
manipulated
on
demand
based
control
over
fluids.
Therefore,
fabricated
been
applied
field,
including
drug
encapsulation,
cell
tissue
engineering.
This
review
introduces
various
synthesized
different
devices,
highlighting
advantages
those
approaches.
Overall,
emerging
technologies
enrich
accelerate
translation
industrial
production
clinical
applications.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 15, 2023
Granular
hydrogels,
which
are
formed
by
densely
packing
microgels,
promising
materials
for
bioprinting
due
to
their
extrudability,
porosity,
and
modularity.
However,
the
multidimensional
parameter
space
involved
in
granular
hydrogel
design
makes
material
optimization
challenging.
For
example,
inputs
such
as
microgel
morphology,
density,
or
stiffness
can
influence
multiple
rheological
properties
that
govern
printability
behavior
of
encapsulated
cells.
This
review
provides
an
overview
fabrication
methods
then
examines
how
important
associated
with
cellular
responses
across
scales.
Recent
applications
principles
bioink
engineering
described,
including
development
support
hydrogels
embedded
printing.
Further,
paper
key
physical
responses,
highlighting
advantages
promoting
cell
tissue
maturation
after
printing
process.
Finally,
potential
future
directions
advancing
discussed.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(7), P. 937 - 937
Published: June 28, 2023
Droplet-based
microfluidics
offer
great
opportunities
for
applications
in
various
fields,
such
as
diagnostics,
food
sciences,
and
drug
discovery.
A
droplet
provides
an
isolated
environment
performing
a
single
reaction
within
microscale-volume
sample,
allowing
fast
with
high
sensitivity,
throughput,
low
risk
of
cross-contamination.
Owing
to
several
remarkable
features,
droplet-based
microfluidic
techniques
have
been
intensively
studied.
In
this
review,
we
discuss
the
impact
microfluidics,
particularly
focusing
on
screening
development.
addition,
surveyed
methods
device
fabrication
generation/manipulation.
We
further
highlight
some
promising
studies
covering
synthesis
delivery
that
were
updated
last
5
years.
This
review
researchers
quick
guide
includes
most
up-to-date
relevant
information
latest
scientific
findings
development
pharmaceutical
field.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(33), P. 8007 - 8032
Published: Jan. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Jan. 4, 2024
Abstract
Acoustic
microfluidic
devices
have
advantages
for
diagnostic
applications,
therapeutic
solutions,
and
fundamental
research
due
to
their
contactless
operation,
simple
design,
biocompatibility.
However,
most
acoustofluidic
approaches
are
limited
forming
fixed
acoustic
patterns,
or
resolution.
In
this
study,a
detachable
device
is
demonstrated
employing
miniature
holograms
create
reconfigurable,
flexible,
high‐resolution
fields
in
channels,
where
the
introduction
of
a
solid
coupling
layer
makes
these
easy
fabricate
integrate.
The
application
method
generate
flexible
fields,
including
shapes,
characters,
arbitrarily
rotated
within
demonstrated.
