Materials Today Nano, Journal Year: 2023, Volume and Issue: 24, P. 100404 - 100404
Published: Aug. 31, 2023
Language: Английский
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown
Published: April 1, 2024
Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 26, 2024
Abstract One‐for‐all phototheranostics based on a single molecule is recognized as convenient approach for cancer treatment, whose efficacy relies precise lesion localization through multimodal imaging, coupled with the efficient exertion of phototherapy. To unleash full potential phototheranostics, advancement in both phototheranostic agents and light delivery methods essential. Herein, an integrated strategy combining versatile featuring aggregation‐induced emission, namely tBuTTBD, modified optical fiber to realize comprehensive tumor diagnosis “inside‐out” irradiation orthotopic breast tumor, proposed first time. Attributed intense donor‐acceptor interaction, highly distorted conformation, abundant molecular rotors, loose intermolecular packing upon aggregation, tBuTTBD can synchronously undergo second near‐infrared (NIR‐II) fluorescence photothermal photodynamic generation under laser irradiation, contributing trimodal NIR‐II fluorescence‐photoacoustic (PA)‐photothermal imaging‐guided The treatment further carried out following insertion fiber, which fabricated by splicing flat‐end air‐core fiber. This configuration aims enable effective situ phototherapy maximizing energy utilization therapeutic benefits. work not only enriches palette but also provides valuable insight exploring protocol practical treatment.
Language: Английский
Citations
9
ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 25144 - 25154
Published: Aug. 27, 2024
Near-infrared II (NIR-II) imaging and photothermal therapy hold tremendous potential in precision diagnosis treatment within biological organisms. However, a significant challenge is the shortage of NIR-II fluorescent probes with both high conversion coefficient (PCE) fluorescence quantum yield (Φ
Language: Английский
Citations
9
Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(52)
Published: Oct. 13, 2022
Abstract Conjugated small‐molecule (CSM) phototheranostic agents that operate in the second near‐infrared (NIR‐II) region have garnered significant attention field of biomedicine. However, a lack fluorescence‐emitting ability hinders their use precise fluorescence imaging (FI)‐guided photothermal therapy (PTT). Herein, two‐pronged intensification strategy—molecular engineering for rational bandgap modulation and lipid‐intercalation to combat quenching—is used develop NIR‐II‐excited ultrabright donor–acceptor–donor‐based (D–A–D)‐based zwitterionic CSM nanoagent tumor phototheranostics. The molecular strategy produces D–A–D‐based fluorophore (BTFQ) exhibits high NIR‐II quantum yield (QY = 0.65%) dichloromethane. More importantly, BTFQ complexed with liposome (DMPC) form zwitterion–liposome (BTFQ/DMPC) shows negligible loss QY (0.63%) aqueous media. Moreover, because BTFQ/DMPC possesses excellent conversion efficiency (PCE 30.8%) performance, it can be realize efficient vivo 1064 nm single‐photon high‐resolution FI guided PTT. This study introduces new avenue development FI/PTT effective treatment.
Language: Английский
Citations
36
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)
Published: July 31, 2023
β-amyloid (Aβ) is one of the important biomarkers for diagnosing Alzheimer's disease (AD). Many near-infrared probes based on donor-π-acceptor structure have been developed to detect Aβ. Most reported Aβ are N,N-dimethylamino group as ideal donor, which a widely accepted binding unit. As such, development fluorescent with improved units urgently required. Therefore, this research three anchoring molecular rotor electron donors consisting cyclic amines different ring sizes developed, namely five-membered (TPyr), six-membered (TPip), and seven-membered (THAI). These new anchored rotors connected 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) named TPyrBDP, TPipBDP, THAIBDP. exhibit high affinities (from 28 54 nm)
Language: Английский
Citations
19
Research, Journal Year: 2023, Volume and Issue: 6
Published: Jan. 1, 2023
Semiconducting polymers (SPs) have shown great feasibility as candidates for near-infrared-II (NIR-II) fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible tunability. However, the signal of traditional SPs tends quench in aggregate states owing π–π stacking, which can lead radiative decay pathway shutting down. To address this issue, aggregation-induced emission effect has been used a rational tactic boost aggregate-state NIR-II emitters. In contribution, we developed precise molecular engineering based on block copolymerizations that integrate planar twisted segments into one conjugated polymer backbone, providing flexibility tuning photophysical properties conversion capacity SPs. Two monomers featured with architectures, respectively, were tactfully incorporated via ternary copolymerization approach produce series new The optimal copolymer (SP2) synchronously shows desirable absorption good quantum yield premise maintaining typical characteristics, resulting balanced brightness property. Water-dispersible nanoparticles fabricated from SP2 show efficient therapeutic effects both vitro vivo. vivo investigation reveals distinguished imaging performance ablation toward tumor prominent accumulation excellent biocompatibility.
Language: Английский
Citations
17
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(4), P. 4420 - 4429
Published: Jan. 19, 2024
Near-infrared-II fluorescence imaging (NIR-II FI) has become a powerful technique for disease diagnosis owing to its superiorities, including high sensitivity, spatial resolution, deep depth, and low background interference. Despite the widespread application of conjugated polymer nanoparticles (CPNs) NIR-II FI, most developed CPNs have quite quantum yields based on energy gap law, which makes high-sensitivity high-resolution toward lesions still huge challenge. This work proposes nanoengineering strategy modulate size aimed at optimizing their performance improved phototheranostics. By adjusting initial concentration synthesized polymer, series with different particle sizes are successfully prepared via nanoprecipitation approach. Results show that brightness gradually amplifies decreasing size, optimal CPNs, NP0.2, demonstrate up 2.05-fold enhancement compared counterpart nanoparticles. With merits reliable biocompatibility, photostability, efficient light-heat conversion, NP0.2 been employed FI-guided photothermal therapy both in vitro vivo. Our highlights an effective improve advancing development FI life sciences.
Language: Английский
Citations
8
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(22)
Published: March 25, 2024
Abstract Luminescence in the second near‐infrared (NIR‐II, 1,000–1,700 nm) window is beneficial especially for deep tissue imaging and optical sensors because of intrinsic high permeability through various media. Strong electron‐acceptors with low‐lying lowest unoccupied molecular orbital (LUMO) energy levels are a crucial unit donor–acceptor (D–A) π‐conjugated polymers (CPs) NIR‐II emission property, however, limited kinds skeletons still available. Herein, D–A CPs involving fluorinated boron‐fused azobenzene complexes (BAz) enhanced electron‐accepting properties reported. Combination fluorination at ligand trifluoromethylation boron can effectively lower LUMO level down to −4.42 eV, which much than those conventional strong electron‐acceptors. The synthesized series showed excellent absorption/fluorescence property solution over wide NIR range including NIR‐II. Furthermore, owing inherent solid‐state emissive BAz skeleton, obvious fluorescence from film (up λ FL =1213 nanoparticle water ( =1036 nm, brightness=up 29 cm −1 M ) were observed, proposing that our materials applicable developing next‐generation luminescent materials.
Language: Английский
Citations
8
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)
Published: May 1, 2024
Abstract Photothermal therapy (PTT) represents a groundbreaking approach to targeted disease treatment by harnessing the conversion of light into heat. The efficacy PTT heavily relies on capabilities photothermal agents (PTAs). Among PTAs, those based organic dyes exhibit notable characteristics such as adjustable absorption wavelengths, high extinction coefficients, and compatibility in biological systems. However, challenge associated with dye‐based PTAs lies their efficiency converting heat while maintaining stability. Manipulating dye aggregation is key aspect modulating non‐radiative decay pathways, aiming augment generation. This review delves various strategies aimed at improving performance through constructing aggregation. These including protecting from photodegradation, inhibiting non‐photothermal space within molecular aggregates, introducing intermolecular photophysical processes. Overall, this highlights precision‐driven assembly promising frontier enhancing PTT‐related applications. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanomedicine for Oncologic Disease Diagnostic Tools In Vivo Nanodiagnostics Imaging
Language: Английский
Citations
7
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 650 - 662
Published: March 18, 2024
Language: Английский
Citations
6