Strontium-calcium doped titanium dioxide nanotubes loaded with GL13K for promotion of antibacterial activity, anti-Inflammation, and vascularized bone regeneration

Ceramics International, Journal Year: 2023, Volume and Issue: 49(22), P. 35703 - 35721

Published: Aug. 22, 2023

Language: Английский

---

Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Jan. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Language: Английский

---

Construction of antibacterial bone implants and their application in bone regeneration

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(3), P. 590 - 625

Published: Nov. 10, 2023

In order to address the issue of bacterial infection during transplantation bone implants, four types implants with long-term antimicrobial functionality have been constructed.

Language: Английский

---

Multifunctional Prosthesis Surface: Modification of Titanium with Cinnamaldehyde‐Loaded Hierarchical Titanium Dioxide Nanotubes

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(14)

Published: Feb. 17, 2024

Abstract Orthopedic prostheses are the ultimate therapeutic solution for various end‐stage orthopedic conditions. However, aseptic loosening and pyogenic infections remain as primary complications associated with these devices. In this study, a hierarchical titanium dioxide (TiO 2 ) nanotube drug delivery system loaded cinnamaldehyde surface modification of implants, is constructed. These specially designed dual‐layer TiO nanotubes enhance material reactivity provide an extensive drug‐loading platform within short time. The introduction enhances bone integration performance scaffold (simultaneously promoting formation inhibiting resorption), anti‐inflammatory capacity, antibacterial properties. vitro experiments have demonstrated that promoted osteogenesis by upregulating both Wnt/β‐catenin MAPK signaling pathways. Furthermore, it inhibits osteoclast formation, suppresses macrophage‐mediated inflammatory responses, impedes proliferation Staphylococcus aureus Escherichia coli. vivo shows in rat model femoral defects. addition, effectively properties subcutaneous implant model. This study provides straightforward highly effective strategy Ti implants.

Language: Английский

---

3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Electrical stimulation has been shown to regulate early immunity and late-stage osteogenesis in bone repair. However, achieving in-situ electrical the form of self-power vivo during initial postoperative stages when patients have limited mobility remains challenging. In this study, we developed a 3D-printed self-powered composite scaffold composed shape memory polyurethane elastomers (SMPU) polyvinylidene fluoride (PVDF) piezoelectric nanofibers. The demonstrates excellent performance, allowing for minimally invasive implantation. During process, can provide mechanical force PVDF nanofibers generate charge. Therefore, was achieved through integration process effects, it be used period. Additionally, output voltage under continuous stimulation, indicating that apply sustained rehabilitation exercises regain mobility. Both cell experiments animal studies confirmed effectively immune microenvironment enhance osteogenesis. This study successfully achieves by integrating which is expected an effective repair strategy tissue engineering.

Language: Английский

---

Electrical Stimulation for Immunomodulation

ACS Omega, Journal Year: 2023, Volume and Issue: 9(1), P. 52 - 66

Published: Dec. 20, 2023

The immune system plays a key role in the development and progression of numerous diseases such as chronic wounds, autoimmune diseases, various forms cancer. Hence, controlling behavior cells has emerged promising approach for treating these diseases. Current modalities immunomodulation focus on chemical based approaches, which while effective have limitations nonspecific systemic side effects or requiring invasive delivery approaches to reduce effects. Recent advances unraveled significance electrical stimulation an attractive noninvasive modulate cell phenotype activity. This review provides insights strategies employed regulating macrophages, T B cells, neutrophils. For obtaining better understanding, two major types sources, conventional self-powered that been used are extensively discussed. Next, may be applied vitro vivo discussed, with stimuli-responsive sources. A description how influence polarization, phagocytosis, migration, differentiation is also provided. Finally, recent developments use highly localized efficient platforms highlighted.

Language: Английский

---

Piezoelectrically-activated antibacterial catheter for prevention of urinary tract infections in an on-demand manner

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101089 - 101089

Published: May 11, 2024

Catheter-associated urinary tract infection (CAUTI) is a common clinical problem, especially during long-term catheterization, causing additional pain to patients. The development of novel antimicrobial coatings needed prolong the service life catheters and reduce incidence CAUTIs. Herein, we designed an catheter coated with piezoelectric zinc oxide nanoparticles (ZnO NPs)-incorporated polyvinylidene difluoride-hexafluoropropylene (ZnO-PVDF-HFP) membrane. ZnO-PVDF-HFP could be stably onto silicone simply by one-step solution film-forming method, very convenient for industrial production. In vitro, it was demonstrated that coating significantly inhibit bacterial growth formation biofilm under ultrasound-mediated mechanical stimulation even after 4 weeks. Importantly, on off activity as well strenth antibacterial property controlled in adaptive manner via ultrasound. rabbit model, ZnO-PVDF-HFP-coated reduced CAUTIs compared clinically-commonly used assistance ultrasonication, no side effect detected. Collectively, study provided prevent occurance CAUTIs, whose on-demand manner, situation promising application.

Language: Английский

---

Piezoelectric polymers and their applications in antimicrobial fields

Materials Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A schematic overview of the classification, key properties, and applications piezoelectric antimicrobial polymers.

Language: Английский

---

Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 21, 2025

Indroduction The rotator cuff tendon-bone interface exhibits a gradient histological composition, including graded mineral content and interwoven collagen fibers. Following injury repair, the lack of compositional, structural, functional at results in stress concentration high rate postoperative re-tears. Piezoelectric materials, known for modulating cellular functions promoting stem cell proliferation differentiation, have garnered increasing attention tissue repair applications. Methods In this study, biomimetic piezoelectric patch with progressive compositional structural variations was designed fabricated. patch, composed gelatin/PLGA/nHA/BTO, integrates aligned random fiber structures. layer mimics tendon-side structure interface, while replicates bone-side structure. Results bioinspired excellent biocompatibility. signals generated under ultrasound stimulation can induce osteogenic tenogenic differentiation cells, as well regulate M2 polarization macrophages, thereby regeneration supraspinatus tendon rabbit model injury. Discussion This study highlights potential patches orthopedic offers new possibilities developing advanced materials to regenerate interface.

Language: Английский

---

Microwave-assisted synthesis of composites based on titanium and hydroxyapatite for dental implantation

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(1), P. 92 - 107

Published: Oct. 26, 2023

Titanium (Ti) and its alloys are widely used in clinical practice. As they not bioactive, hydroxyapatite (HA) is commonly to modify them. This study offered a review of microwave-assisted synthesis composites based on Ti HA for dental implantation by exploring their interaction mechanisms with microwave features two main techniques, namely coating sintering, along current challenges potential solutions the field. It was shown that enables rapid deposition HA, but suffers from problems such as uneven thickness, poor integrity unstable composition products. They can be solved creating interlayers, combining spin technique, etc. Unlike coating, sintering effectively mechanical properties composites, despite shortcomings excessive elastic moduli decomposition. These issues expected addressed adding alloying elements employing appropriate materials space holders ion-doped sintering.

Language: Английский

---