Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101761 - 101761
Published: April 11, 2025
PARP
inhibitor
(PARPi)-based
synthetic
lethal
therapies
have
displayed
limited
benefits
in
BRCA-proficient
ovarian
cancer.
To
potentiate
the
application
of
PARPi,
an
ultrasound
contrast
agent
OLA-NDs
for
delivery
PARPi
olaparib
(OLA)
was
established
enhancing
DNA
damage
by
blocking
repair.
were
endowed
with
endogenous
pH-
and
exogenous
(US)-responsiveness
to
target
tumors,
as
well
contrast-enhanced
US
imaging
diagnostic
therapeutic
integration.
could
upregulate
NOX4
induce
oxidative
stress
sensitize
BRCA
wild-type
A2780
cells
through
utilization
ultrasound-targeted
microbubble
destruction
(UTMD).
In
addition,
strategy
further
increased
ROS
production
interfering
mitochondrial
function,
thereby
exacerbating
double-strand
breaks
(DSBs)
inducing
mitochondria-mediated
apoptosis.
As
a
consequence,
combined
UTMD
demonstrated
significant
antitumor
effects
vitro
vivo.
This
amplifying
improved
lethality
promoting
DSBs
apoptosis
reduced
adverse
side
effects,
which
would
provide
new
insight
clinical
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 25, 2024
Abstract
The
growth
state
of
tumor
cells
is
strictly
affected
by
the
specific
abnormal
redox
status
microenvironment
(TME).
Moreover,
reactions
at
biological
level
are
also
central
and
fundamental
to
essential
energy
metabolism
in
tumors.
Accordingly,
anti‐tumor
nanodrugs
targeting
disruption
this
homeostasis
have
become
one
hot
spots
field
research
due
effectiveness
TME
modulation
efficiency
mediated
interference.
This
review
discusses
latest
results
therapy,
which
regulate
levels
oxidants
or
reductants
through
a
variety
therapeutic
strategies,
ultimately
breaking
original
“stable”
promoting
cell
death.
With
gradual
deepening
study
on
vigorous
development
nanomaterials,
it
expected
that
more
nano
drugs
based
regulation
will
be
designed
even
applied
clinically.
Small Science,
Journal Year:
2024,
Volume and Issue:
4(3)
Published: Jan. 17, 2024
Despite
the
great
potential
of
cuproptosis
in
tumor
therapy,
current
cuproptosis‐based
therapy
still
suffers
from
compromised
efficiency
immune
activation.
Pyroptosis,
a
proinflammatory
cell
death
modality,
provides
good
opportunity
to
induce
immunogenic
(ICD)
and
promote
systemic
response.
However,
synergistic
pyroptosis
has
not
been
fully
explored.
Herein,
it
is
discovered
that
Cu(II)‐based
metal–organic
framework
(MOF)
nanoparticles
(NPs)
can
synergistically
evoke
ICD
for
high‐efficiency
tumor‐targeted
immunotherapy.
Although
MOF‐199
widely
used
immunogenicity
unclear.
Pluronic
F127‐modified
NPs
(
F127
NPs)
show
dual‐responsiveness
glutathione
(GSH)
hydrogen
sulfide
(H
2
S).
Once
entering
cancer
cells,
dissociate
GSH‐enriched
microenvironment
(TME)
release
copper
ion
copper‐overload‐mediated
cuproptosis.
Meanwhile,
transform
Cu
2−
x
S
by
situ
sulfidation
under
H
S‐enriched
colorectal
(CRC)
TME.
Under
photothermal
chemodynamic
(PTT/CDT)
NPs,
caspase‐3
activated
gasdermin
E
(GSDME)‐related
triggered.
The
have
proved
superior
antitumor
immunity
effect
both
vitro
vivo
experiments.
This
work
new
strategy
achieve
immunotherapy
with
high
simple
NPs.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(26), P. 17267 - 17281
Published: June 13, 2024
Intrinsic
or
acquired
resistance
to
chemical
drugs
severely
limits
their
therapeutic
efficacy
in
cancer
treatment.
Various
intracellular
antioxidant
molecules,
particularly
glutathione
(GSH),
play
a
crucial
role
maintaining
redox
homeostasis
by
mitigating
the
overproduced
reactive
oxygen
species
(ROS)
due
rapid
cell
proliferation.
Notably,
these
antioxidants
also
eliminate
chemical-drug-induced
ROS,
eventually
diminishing
cytotoxicity
and
rendering
them
less
effective.
In
this
study,
we
combined
erastin,
GSH
biosynthesis
inhibitor,
with
2'-deoxy-5-fluorouridine
5'-monophosphate
sodium
salt
(FdUMP),
an
ROS-based
drug,
effectively
disrupt
reverse
chemotherapy
resistance.
Therefore,
efficient
ferroptosis
apoptosis
were
simultaneously
induced
for
enhanced
antitumor
effects.
Additionally,
employed
small
interfering
RNA
targeting
PD-L1
(siPD-L1)
as
third
agent
block
immune-checkpoint
recognition
CD8
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(9), P. 7267 - 7286
Published: Feb. 21, 2024
Cancer
progression
and
treatment-associated
cellular
stress
impairs
therapeutic
outcome
by
inducing
resistance.
Endoplasmic
reticulum
(ER)
is
responsible
for
core
events.
Aberrant
activation
of
sensors
their
downstream
components
to
disrupt
homeostasis
have
emerged
as
vital
regulators
tumor
well
response
cancer
therapy.
Here,
an
orchestrated
nanophotoinducer
(ERsNP)
results
in
specific
ER-homing,
induces
hyperthermia
mounting
oxidative
associated
reactive
oxygen
species
(ROS),
provokes
intense
lethal
ER
upon
near-infrared
laser
irradiation.
The
strengthened
"dying"
ROS
subsequently
induce
apoptosis
both
primary
abscopal
B16F10
GL261
tumors,
promote
damage-associated
molecular
patterns
evoke
stress-dependent
immunogenic
cell
death
effects
release
"self-antigens".
Thus,
there
a
cascade
activate
maturation
dendritic
cells,
reprogram
myeloid-derived
suppressor
cells
manipulate
immunosuppression,
recruit
cytotoxic
T
lymphocytes
effective
antitumor
response.
long-term
protection
against
recurrence
realized
through
cascaded
combinatorial
preoperative
postoperative
photoimmunotherapy
including
the
chemokine
(C-C
motif)
receptor
2
antagonist,
ERsNP
irradiation,
immune
checkpoint
inhibitor.
highlight
great
promise
exert
potent
reinforcing
boost
photoimmunotherapy.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 27, 2024
Abstract
Reactive
oxygen
species
(ROS)‐mediated
emerging
treatments
exhibit
unique
advantages
in
cancer
therapy
recent
years.
While
the
efficacy
of
ROS‐involved
tumor
is
greatly
restricted
by
complex
microenvironment
(TME).
Herein,
a
dual‐metal
CaO
2
@CDs‐Fe
(CCF)
nanosphere,
with
TME
response
and
regulation
capabilities,
are
proposed
to
improve
ROS
lethal
power
multiple
cascade
synergistic
therapeutic
strategy
domino
effect.
In
weak
acidic
TME,
CCF
will
decompose,
accompanied
intracellular
Ca
2+
upregulated
abundant
H
O
produced
reverse
antitherapeutic
TME.
Then
exposed
CF
cores
can
act
as
both
Fenton
agent
sonosensitizer
generate
excessive
regulated
for
enhanced
CDT/SDT.
combination
calcium
overloading,
augmented
induced
oxidative
stress
cause
more
severe
mitochondrial
damage
cellular
apoptosis.
Furthermore,
also
reduce
GPX4
expression
enlarge
lipid
peroxidation,
causing
ferroptosis
apoptosis
parallel.
These
signals
finally
initiate
damage‐associated
molecular
patterns
activate
immune
realize
excellent
antitumor
This
outstanding
ROS/calcium
loading
effect
endows
anticancer
efficiently
eliminate
apoptosis/ferroptosis/ICD
vitro
vivo.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(4)
Published: May 11, 2023
Abstract
Poor
immunogenicity
seriously
hampers
the
broader
implementation
of
antitumor
immunotherapy.
Enhanced
capable
achieving
greater
immunity
is
urgently
required.
Here,
a
novel
polymer
that
contains
hydrophobic
ferrocene
(Fc)
units
and
thioketal
bonds
in
main
chain,
which
further
delivered
prodrug
oxaliplatin
artesunate,
i.e.,
Artoxplatin,
to
cancer
cells
described.
This
with
Fc
nanoparticle
can
work
as
polyigniter
spark
peroxide
Artoxplatin
generate
abundant
reactive
oxygen
species
(ROS)
kill
cancers
nanobomb
ig
for
therapy.
Moreover,
ROS
trigger
breakdown
polymer,
resulting
biodegradation
polymer.
Importantly,
facilitate
maturation
dendritic
promote
activation
immunity,
through
enhanced
immunogenic
cell
death
effect
by
generated
situ.
Furthermore,
metabolomics
analysis
reveals
decrease
glutamine
‐treated
cells,
upregulation
programmed
ligand
1
(PD‐L1).
Consequently,
it
demonstrated
tumor
inhibitory
effects
when
using
combined
anti‐PD‐L1
Overall,
nanosystem
offers
rational
design
an
efficient
chemo‐immunotherapy
regimen
improving
immunogenicity,
addressing
key
challenges
immunotherapy
faced.
