Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 204, P. 104505 - 104505
Published: Sept. 8, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12386 - 12400
Published: May 3, 2024
Current cancer vaccines face challenges due to an immunosuppressive tumor microenvironment and their limited ability produce effective immune response. To address the above limitations, we develop a 3-(2-spiroadamantyl)-4-methoxy-4-(3-phosphoryloxy)-phenyl-1,2-dioxetane (alkaline phosphatase substrate) XMD8-92 (extracellular signal-regulated kinase 5 inhibitor)-codelivered copper-tetrahydroxybenzoquinone (Cu-THBQ/AX) nanosized metal–organic framework in situ-generate therapeutic vaccination. Once inside early endosome, alkaline overexpressed cells' membrane activates situ type I photodynamic effect of Cu-THBQ/AX for generating •O2–, catalyzes O2 H2O2 •O2– •OH via semiquinone radical catalysis Fenton-like reactions. This surge ROS endosomes triggers caspase-3-mediated proinflammatory pyroptosis activating phospholipase C. Meanwhile, can also induce oligomerization dihydrolipoamide S-acetyltransferase trigger cell cuproptosis. The production could release effectively inhibiting efferocytosis macrophages convert apoptosis cells into secondary necrosis. simultaneous induction pyroptosis, cuproptosis, necrosis converts from "cold" "hot" conditions, making it antigen pool. transformation successfully antitumor response, growth metastasis.
Language: Английский
Citations
19
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: April 15, 2024
Abstract Cuproptosis, a recently identified non‐apoptotic programmed cell death modality, attracts considerable attention in the realm of cancer therapeutics owing to its unique cellular demise mechanisms. Since initial report 2022, strategies inducing or amplifying cuproptosis for treatment emerge. The engineering nano‐systems elicit effectively circumvents constraints associated with conventional small‐molecule pharmaceutical interventions, presenting novel prospects oncological therapy. Stimulus‐responsive nanomaterials, leveraging their distinctive spatiotemporal control attributes, are investigated role modulating induction augmentation cuproptosis. In this comprehensive review, physiological characteristics cuproptosis, encompassing facets such as copper overload and depletion, coupled regulatory factors intrinsic expounded upon. Subsequently, design methodologies stimulus‐responsive enhancement employing stimuli light, ultrasound, X‐ray, tumor microenvironment, systematically delineated. This review encompasses intricacies nanomaterial design, insights into therapeutic processes, advantages. Finally, challenges inherent induction/enhancement deliberated upon prospective future trajectory copper‐mediated therapy provided.
Language: Английский
Citations
16
ACS Nano, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Chemodynamic therapy (CDT) can induce cancer cell death through hydroxyl radicals (·OH) generated from Fenton or Fenton-like reactions. Compared with traditional therapies, CDT effectively overcomes inevitable drug resistance and exhibits low side effects. However, clinical application still faces challenges, primarily due to insufficient ·OH generation the short-lifetime of in vivo. To address these we developed a peroxynitrite (ONOO
Language: Английский
Citations
10
Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.
Language: Английский
Citations
1
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969
Published: June 10, 2024
Language: Английский
Citations
8
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139984 - 139984
Published: Sept. 11, 2024
Language: Английский
Citations
7
Nanoscale, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
A novel calcium-based nanoinducer that simultaneously induces pyroptosis and remodels tumor-associated-macrophages effectively overcomes the immunosuppression for enhancing systemic antitumor immunity.
Language: Английский
Citations
5
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 249 - 268
Published: Sept. 12, 2024
Language: Английский
Citations
5