Glucose Oxidase Energized Osmium with Dual‐Active Centers and Triple Enzyme Activities for Infected Diabetic Wound Management

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 20, 2024

Diabetic wounds are susceptible to bacterial infections, largely linked high blood glucose levels (hyperglycemia). To treat such wounds, enzymes like oxidase (GOx) can be combined with nanozymes (nanomaterials mimic enzymes) use effectively for purposes. However, there is still room improvement in these systems, particularly terms of process simplification, enzyme activity regulation, and treatment effects. Herein, the approach utilizes GOx directly facilitate biomineralized growth osmium (Os) nanozyme (GOx-OsNCs), leading dual-active centers remarkable triple activities. Initially, GOx-OsNCs vicinal centers, enabling a self-cascaded mechanism that significantly enhances sensing performance compared step-by-step reactions, surpassing capabilities other metal sources as gold platinum. In addition, integrated into glucose-sensing gel, instantaneous visual feedback. infected diabetic exhibit multifaceted benefits by lowering exhibiting antibacterial properties through generation hydroxyl free radicals, thereby expediting healing fostering favorable microenvironment. Furthermore, catalase-like aids reducing oxidative stress, inflammation, hypoxia, culminating improved outcomes. Overall, this synergistic enzyme-nanozyme blend user-friendly holds considerable promise diverse applications.

Language: Английский

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Space-confined nanozyme with cascade reaction based on PCN-224 for synergistic bacterial infection treatment and NIR fluorescence imaging of wound bacterial infections

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150642 - 150642

Published: March 26, 2024

Language: Английский

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One‐Step Synthesis of Hydrogel Adhesive with Acid‐Responsive Tannin Release for Diabetic Oral Mucosa Defects Healing

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(9)

Published: Jan. 21, 2024

Abstract The complex preparation, weak wet tissue adhesion, and limited biological activity of traditional oral wound dressings usually impede their efficient treatment healing for diabetic mucosal defects. To overcome these problems, a novel hydrogel adhesive (named CFT hydrogel) is rapidly constructed using one‐step method based on dual‐dynamic covalent cross‐linking. Compared with the commercial patches, shows superior in vivo (rat tongue) adhesion performance. Additionally, exhibits unique acid‐responsive properties, thereby facilitating release bioactive molecule tannic acid acidic microenvironment. And series vitro experiments substantiate favorable biocompatibility bioactivity properties (including antibacterial, antioxidative, anti‐inflammatory, angiogenetic effects) exhibited by hydrogel. Moreover, conducted rat model defects demonstrate that significant efficacy protecting against wounds, alleviating inflammatory reactions, wound‐healing process. Taken together, this study provides promising comprehensive therapeutic option great potential clinical management mucosa patients.

Language: Английский

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Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management

View, Journal Year: 2024, Volume and Issue: 5(4)

Published: July 18, 2024

Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for decades because their potential roles in cellular communication, tissue regeneration, drug delivery. As powerful tools controlled‐sustained release sEVs, biocompatible hydrogels applied wide range biomedical applications. Herein, we first summarize pathological features such as angiopathy, neuropathy, immune cell dysfunction. Then, discuss biological properties, performance, stability pure MSC‐sEVs. After that, components, application patterns, responsiveness hydrogels. Next, loading avenues MSC‐sEVs into hydrogel, behaviors sEVs from hydrogels, influence crosslinking method hydrogel‐sEV composites. Finally, provide an overview current applications loaded with novel cell‐free engineering system managing wounds propose critical unsolved issues. This review is expected meaningful guidance developing wound management.

Language: Английский

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Versatile conductive hydrogel orchestrating neuro–immune microenvironment for rapid diabetic wound healing through peripheral nerve regeneration

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122841 - 122841

Published: Sept. 14, 2024

Language: Английский

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