GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Currently, the clinical treatment of critical bone defects attributed to various causes remains a great challenge, and repairing these with synthetic substitutes is most common strategy. In general, tissue engineering materials that mimic structural, mechanical biological properties natural have been extensively applied fill promote in situ regeneration. Hydrogels extracellular matrix (ECM)-like are materials, among which methacrylate-based gelatin (GelMA) hydrogels widely used because their tunable properties, excellent photocrosslinking capability good biocompatibility. Owing lack osteogenic activity, however, GelMA combined other types activities improve current composites. There three main aspects consider when enhancing regenerative performance composite materials: osteoconductivity, vascularization osteoinduction. Bioceramics, bioglass, biomimetic scaffolds, inorganic ions, bionic periosteum, growth factors two-dimensional (2D) nanomaterials combinations achieve enhanced regeneration activities. Three-dimensional (3D)-bioprinted scaffolds popular research topic (BTE), printed customized suitable for restoring large irregular due shape structural tunability, Herein, recent progress on GelMA-based hydrogel as multifunctional platforms plastic or orthopedic clinics systematically reviewed summarized. These strategies pave way design effective reconstruction biosafety. This review provides novel insights into development trends (BTE) correcting defects, contents summarized emphasized from perspectives (osteoconductivity, vascularization, osteoinduction 3D-bioprinting). addition, advantages deficiencies put forward, corresponding improvement measures presented prior application near future (created BioRender.com).

Language: Английский

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Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 346 - 373

Published: May 9, 2024

Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions

Language: Английский

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Bioactive elements manipulate bone regeneration.

PubMed, Journal Year: 2023, Volume and Issue: 4(4), P. 248 - 269

Published: Jan. 1, 2023

While bone tissue is known for its inherent regenerative abilities, various pathological conditions and trauma can disrupt meticulously regulated processes of formation resorption. Bone engineering aims to replicate the extracellular matrix as well sophisticated biochemical mechanisms crucial effective regeneration. Traditionally, field has relied on external agents like growth factors pharmaceuticals modulate these processes. Although efficacious in certain scenarios, this strategy compromised by limitations such safety issues transient nature compound release half-life. Conversely, bioactive elements zinc (Zn), magnesium (Mg) silicon (Si), have garnered increasing interest their therapeutic benefits, superior stability, reduced biotic risks. Moreover, are often incorporated into biomaterials that function multifaceted components, facilitating regeneration via on-demand. By elucidating mechanistic roles efficacy elements, review establish a robust clinically viable advanced

Language: Английский

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Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(22), P. 7268 - 7295

Published: Jan. 1, 2023

Schematic representation of the basic regulatory strategies, metal ions commonly used, and ion-based biomaterials for bone regeneration presented in this review.

Language: Английский

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Emerging roles of nerve‐bone axis in modulating skeletal system

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(4), P. 1867 - 1903

Published: Feb. 29, 2024

Over the past decades, emerging evidence in literature has demonstrated that innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The nerve-bone axis sparked extensive preclinical clinical investigations aimed at elucidating contribution crosstalks to skeleton metabolism, homeostasis, injury repair through perspective neurobiology. To date, peripheral nerves have been widely reported mediate growth development fracture healing via secretion neurotransmitters, neuropeptides, axon guidance factors, neurotrophins. Relevant studies further identified several critical neural pathways stimulate profound alterations cell biology, revealing complex interplay between nerve systems. In addition, inspired by crosstalk, novel drug delivery systems bioactive materials developed emulate facilitate process natural neuromodulation, eventually boosting osteogenesis ideal tissue regeneration. Overall, this work aims review research findings contribute deepening current understanding axis, bringing forth some schemas can be translated into scenario highlight roles neuromodulation system.

Language: Английский

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Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 334 - 344

Published: June 15, 2024

Language: Английский

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Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

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Strategies for promoting neurovascularization in bone regeneration

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 3, 2025

Abstract Bone tissue relies on the intricate interplay between blood vessels and nerve fibers, both are essential for many physiological pathological processes of skeletal system. Blood provide necessary oxygen nutrients to bone tissues, remove metabolic waste. Concomitantly, fibers precede during growth, promote vascularization, influence cells by secreting neurotransmitters stimulate osteogenesis. Despite critical roles components, current biomaterials generally focus enhancing intraosseous vessel repair, while often neglecting contribution nerves. Understanding distribution main functions in is crucial developing effective engineering. This review first explores anatomy highlighting their vital embryonic development, metabolism, repair. It covers innovative regeneration strategies directed at accelerating intrabony neurovascular system over past 10 years. The issues covered included material properties (stiffness, surface topography, pore structures, conductivity, piezoelectricity) acellular biological factors [neurotrophins, peptides, ribonucleic acids (RNAs), inorganic ions, exosomes]. Major challenges encountered neurovascularized materials clinical translation have also been highlighted. Furthermore, discusses future research directions potential developments aimed producing repair that more accurately mimic natural healing tissue. will serve as a valuable reference researchers clinicians novel into practice. By bridging gap experimental practical application, these advancements transform treatment defects significantly improve quality life patients with bone-related conditions.

Language: Английский

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Advances in Conductive Hydrogel for Spinal Cord Injury Repair and Regeneration

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7305 - 7333

Published: Dec. 1, 2023

Abstract: Spinal cord injury (SCI) treatment represents a major challenge in clinical practice. In recent years, the rapid development of neural tissue engineering technology has provided new therapeutic approach for spinal repair. Implanting functionalized electroconductive hydrogels (ECH) area been shown to promote axonal regeneration and facilitate generation neuronal circuits by reshaping microenvironment SCI. ECH not only intercellular electrical signaling but, when combined with stimulation, enable transmission signals electroactive activate bioelectric pathways, thereby promoting Therefore, implantation into damaged tissues can effectively restore physiological functions related conduction. This article focuses on dynamic pathophysiological changes SCI discusses mechanisms stimulation/signal process By examining activity during nerve repair, we provide insights behind stimulation We classify conductive biomaterials, offer an overview current applications research progress repair regeneration, aiming reference future explorations developments strategies. Keywords: engineering, signal,

Language: Английский

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Advances in electroactive bioscaffolds for repairing spinal cord injury

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(3), P. 032005 - 032005

Published: April 18, 2024

Spinal cord injury (SCI) is a devastating neurological disorder, leading to loss of motor or somatosensory function, which the most challenging worldwide medical problem. Re-establishment intact neural circuits basis spinal regeneration. Considering crucial role electrical signals in nervous system, electroactive bioscaffolds have been widely developed for SCI repair. They can produce conductive pathways and pro-regenerative microenvironment at lesion site similar that natural cord, neuronal regeneration axonal growth, functionally reactivating damaged circuits. In this review, we first demonstrate pathophysiological characteristics induced by SCI. Then, repair introduced. Based on comprehensive analysis these characteristics, recent advances are summarized, focusing both piezoelectric bioscaffolds, used independently combination with external electronic stimulation. Finally, thoughts challenges opportunities may shape future concluded.

Language: Английский

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