RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(7), P. 5117 - 5123
Published: Jan. 1, 2025
Polyphenols
exhibit
strong
antioxidant,
and
anti-inflammatory
but
are
limited
by
chemical
instability
low
bioavailability.
To
address
these
challenges,
we
developed
polyphenol-amino
acid
conjugates
that
self-assemble
into
stable
nanospheres,
enhancing
their
stability
These
nanoparticles
demonstrate
significantly
improved
ROS
scavenging
efficiency
promote
cell
proliferation
in
vitro.
The
incorporation
of
amino
acids
enhances
biocompatibility
facilitates
effective
elimination.
offer
a
multifaceted
therapeutic
strategy
to
mitigate
oxidative
stress,
overcoming
traditional
antioxidant
limitations
through
advanced
nanotechnology.
This
approach
contributes
the
development
next-generation
wound
care
solutions
with
enhanced
efficacy
safety
profiles.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(6), P. 654 - 654
Published: May 27, 2024
The
search
results
offer
comprehensive
insights
into
the
phenolic
compounds,
antioxidant,
anti-inflammatory,
cytotoxic
effects,
LC-MS/MS
analysis,
molecular
docking,
and
MD
simulation
of
identified
compounds
in
Astragalus
arpilobus
subsp.
hauarensis
extract
(AAH).
analysis
revealed
substantial
levels
total
content
(TPC),
with
a
measured
value
191
±
0.03
mg
GAE/g
DM.
This
high
TPC
was
primarily
attributed
to
two
key
compounds:
flavonoid
(TFC)
tannin
(TTC),
quantified
at
80.82
0.02
QE/g
DM
51.91
0.01
CE/g
DM,
respectively.
28
gallic
acid,
protocatechuic
catechin,
others.
In
DPPH
scavenging
assay,
IC50
for
determined
be
19.44
0.04
μg/mL,
comparable
standard
antioxidants
like
BHA,
BHT,
ascorbic
α-tocopherol.
Regarding
anti-inflammatory
activity,
demonstrated
notably
lower
compared
both
diclofenac
ketoprofen,
values
35.73
µg/mL,
63.78
164.79
Cytotoxicity
significant
cytotoxicity
A.
extract,
an
LC50
28.84
which
exceeded
that
potassium
dichromate
(15.73
µg/mL),
indicating
its
potential
as
safer
alternative
various
applications.
Molecular
docking
studies
have
highlighted
chrysin
promising
COX-2
inhibitor,
favorable
binding
energies
interactions.
dynamic
simulations
further
support
chrysin’s
potential,
showing
stable
interactions
COX-2,
reference
ligand
S58.
Overall,
study
underscores
pharmacological
particularly
chrysin,
source
bioactive
antioxidant
properties.
Further
research
is
warranted
elucidate
therapeutic
mechanisms
clinical
implications
these
natural
compounds.
Gels,
Journal Year:
2024,
Volume and Issue:
10(1), P. 68 - 68
Published: Jan. 17, 2024
Hemostatic
powder,
which
can
absorb
large
amounts
of
water
and
tends
to
produce
repeated
hydration
with
tissue,
has
been
clinically
proven
as
an
ideal
engineering
material
for
treating
wounds
tissues.
We
herein
designed
a
polypeptide-based
hemostatic
powder.
A
water-soluble
polypeptide,
γ-polyglutamic
acid
(γ-PGA),
was
mixed
the
polyethyleneimine
(PEI),
N-hydroxysuccinimide,
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.
The
solution
these
polymers
lyophilized
harvest
γ-PGA/PEI
powder
(PP
powder).
When
deposited
on
bleeding
wound,
PP
quickly
amount
blood
interstitial
fluid,
concentrate
coagulation
factors,
coagulate
cells,
eventually
form
stable
mechanical
hydrogel.
wound
time
group
1.8
±
0.4
min,
significantly
lower
than
that
commercial
chitosan
(2.8
min).
endowed
antioxidant
capacity
by
introducing
protocatechuic
aldehyde,
effectively
inhibit
inflammation
promote
healing.
Therefore,
via
preparation
through
facile
lyophilization
method,
is
expected
find
wide
application
prospect
qualified
