Clinical development and potential of photothermal and photodynamic therapies for cancer

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(11), P. 657 - 674

Published: July 22, 2020

Language: Английский

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(35), P. 14789 - 14804

Published: Aug. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Language: Английский

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Advances in nanomaterials for photodynamic therapy applications: Status and challenges

Biomaterials, Journal Year: 2020, Volume and Issue: 237, P. 119827 - 119827

Published: Jan. 27, 2020

Language: Английский

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Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

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Activatable Molecular Probes for Second Near‐Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(29), P. 11717 - 11731

Published: March 5, 2020

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence biological tissue between 650-900 nm, conventional optical often has poor signal-to-background ratio shallow penetration depth, which limits its ability deep-tissue vivo imaging. Second near-infrared fluorescence, chemiluminescence, photoacoustic modalities mitigate these issues by their respective advantages of minimized scattering, eliminated external excitation, ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the change second or signals response biomarker have been developed. This Minireview summarizes design strategies, sensing mechanisms, applications AMPs. The potential challenges perspectives AMPs are also discussed.

Language: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI), photodynamic therapy (PDT), (PTT). Herein, simple highly powerful one‐for‐all based aggregation‐induced emission (AIE)‐active fluorophores tactfully designed constructed. Thanks its strong electron donor–acceptor interaction finely modulated intramolecular motion, AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) emission, efficient reactive oxygen generation, high conversion efficiency upon NIR irradiation, indicating actualization balance between dissipations. Furthermore, unprecedented performance NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT demonstrated by precise tumor diagnosis complete elimination outcomes. This study thus brings new insight into development superior for practical cancer theranostics.

Language: Английский

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: March 9, 2020

Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at morphological levels. An dye emitting up 1600 nm quantum yield 11.5% NIR-II region is developed. fluorescence blood vessels deeply-located intestinal tract live mice based on dyes achieved high clarity enhanced signal-to-background ratio. We hope this study will inspire further development evolution bio-imaging.

Language: Английский

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Room‐Temperature Phosphorescence Resonance Energy Transfer for Construction of Near‐Infrared Afterglow Imaging Agents

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(52)

Published: Nov. 11, 2020

Abstract Afterglow imaging that detects photons after cessation of optical excitation avoids tissue autofluorescence and thus possesses higher sensitivity than traditional fluorescence imaging. Purely organic molecules with room‐temperature phosphorescence (RTP) have emerged as a new library benign afterglow agents. However, most RTP luminogens only emit visible light shallow penetration, constraining their in vivo applications. This study presents an nanoprobe (mTPA‐N) emission the NIR range for Such probe is composed molecule (mTPA) phosphorescent generator NIR‐fluorescent dye energy acceptor to enable resonance transfer (RT‐PRET), ultimately resulting redshifted at 780 nm. Because elimination background noise luminescence biologically transparent window, mTPA‐N permits lymph nodes living mice high signal‐to‐noise ratio. opens up universal approach develop into agents via construction RT‐PRET.

Language: Английский

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