Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

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Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(23), P. 12971 - 12979

Published: March 27, 2021

Abstract Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia easily repaired stress‐induced shock proteins (HSPs). Thus, maximizing PTT efficiency minimizing healthy simultaneously adopting appropriate temperatures imperative. Herein, innovative strategy reported: ferroptosis‐boosted based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) glutathione oxidase (GSHOx) mimicking activities, photothermal conversion performance, which can result in ferroptosis featuring up‐regulation lipid peroxides (LPO) reactive oxygen species (ROS). accumulation LPO ROS provides powerful approach for cleaving HSPs, enables SAzyme‐mediated mild‐temperature PTT.

Language: Английский

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Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

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GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(42)

Published: Sept. 11, 2020

Abstract Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity nanozymes in tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi @DMSN) then decorating ultrasmall ceria into large mesopores @DMSN. The exhibit dual enzyme‐mimic activities (peroxidase‐mimic catalase‐mimic) under acidic conditions that can regulate TME, is, simultaneously elevate oxidative stress relieve hypoxia. In addition, effectively consume overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) introduced to synergistically improve enzyme‐mimicking depletion GSH tumors photonic hyperthermia. This achieved taking advantage desirable light absorbance second near‐infrared (NIR‐II) window nanozymes. Subsequently reactive oxygen species (ROS)‐mediated efficiency significantly improved. Therefore, this study provides proof concept hyperthermia‐augmented multi‐enzymatic ablation.

Language: Английский

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High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 5735 - 5751

Published: March 11, 2021

As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) produce highly toxic hydroxyl radicals (•OH) kill cells. However, limited by the low affinity between with H2O2 and level of in microenvironment, peroxidase usually produced insufficient •OH cells therapeutic purposes. Herein, we present a pyrite nanozyme ultrahigh affinity, resulting 4144- 3086-fold increase compared that classical Fe3O4 natural horseradish peroxidase, respectively. We found also possesses intrinsic glutathione oxidase-like activity, which catalyzes oxidation reduced accompanied generation. Thus, dual-activity constitutes self-cascade platform generate abundant deplete glutathione, induces apoptosis as well ferroptosis Consequently, it killed apoptosis-resistant harboring KRAS mutation inducing ferroptosis. The exhibited favorable tumor-specific cytotoxicity biodegradability ensure its biosafety. These results indicate high-performance is an effective reagent may aid development nanozyme-based

Language: Английский

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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(22)

Published: April 27, 2020

Abstract Although cancer immunotherapy has emerged as a tremendously promising therapy method, it remains effective only for several cancers. Photoimmunotherapy (e.g., photodynamic/photothermal therapy) could synergistically enhance the immune response of immunotherapy. However, excessively generated immunogenicity will cause serious inflammatory syndrome. Herein, biomimetic magnetic nanoparticles, Fe 3 O 4 ‐SAS @ PLT, are reported novel approach to sensitize ferroptosis and generate mild immunogenicity, enhancing rate non‐inflamed tumors ‐SAS@PLT built from sulfasalazine (SAS)‐loaded mesoporous nanoparticles (Fe ) platelet (PLT) membrane camouflage triggered ferroptotic cell death via inhibiting glutamate‐cystine antiporter system X c − pathway. PLT‐mediated significantly improves efficacy programmed 1 checkpoint blockade achieves continuous tumor elimination in mouse model 4T1 metastatic tumors. Proteomics studies reveal that not induce tumor‐specific but also efficiently repolarize macrophages immunosuppressive M2 phenotype antitumor M1 phenotype. Therefore, concomitant with expected provide great potential clinical treatment metastasis.

Language: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

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MnO_x Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(38), P. 16381 - 16384

Published: June 2, 2020

Abstract Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, intrinsic immunogenicity MONs is still unclear. MnO x nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. NSs with large mesoporous structures show ultrahigh loading efficiencies ovalbumin fragment. The combination ICD via chemodynamic therapy ferroptosis inductions, well antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal growth metastasis.

Language: Английский

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