Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 22, 2023
Abstract
Macrophages
exist
in
various
tissues,
several
body
cavities,
and
around
mucosal
surfaces
are
a
vital
part
of
the
innate
immune
system
for
host
defense
against
many
pathogens
cancers.
possess
binary
M1/M2
macrophage
polarization
settings,
which
perform
central
role
an
array
tasks
via
intrinsic
signal
cascades
and,
therefore,
must
be
precisely
regulated.
Many
crucial
questions
about
signaling
modulation
yet
to
uncovered.
In
addition,
clinical
importance
tumor-associated
macrophages
is
becoming
more
widely
recognized
as
significant
progress
has
been
made
understanding
their
biology.
Moreover,
they
integral
tumor
microenvironment,
playing
regulation
wide
variety
processes
including
angiogenesis,
extracellular
matrix
transformation,
cancer
cell
proliferation,
metastasis,
immunosuppression,
resistance
chemotherapeutic
checkpoint
blockade
immunotherapies.
Herein,
we
discuss
signaling,
mechanical
stresses
modulation,
metabolic
pathways,
mitochondrial
transcriptional,
epigenetic
regulation.
Furthermore,
have
broadly
extended
traps
essential
roles
autophagy
aging
regulating
functions.
discussed
recent
advances
macrophages-mediated
autoimmune
diseases
tumorigenesis.
Lastly,
targeted
therapy
portray
prospective
targets
therapeutic
strategies
health
diseases.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(8), P. 4999 - 5041
Published: March 31, 2021
Manipulation
and
navigation
of
micro
nanoswimmers
in
different
fluid
environments
can
be
achieved
by
chemicals,
external
fields,
or
even
motile
cells.
Many
researchers
have
selected
magnetic
fields
as
the
active
actuation
source
based
on
advantageous
features
this
strategy
such
remote
spatiotemporal
control,
fuel-free,
high
degree
reconfigurability,
programmability,
recyclability,
versatility.
This
review
introduces
fundamental
concepts
advantages
micro/nanorobots
(termed
here
"MagRobots")
well
basic
knowledge
materials,
setups
for
manipulation,
field
configurations,
symmetry-breaking
strategies
effective
movement.
These
are
discussed
to
describe
interactions
between
fields.
Actuation
mechanisms
flagella-inspired
MagRobots
(i.e.,
corkscrew-like
motion
traveling-wave
locomotion/ciliary
stroke
motion)
surface
walkers
surface-assisted
motion),
applications
other
propulsion
approaches,
stimulation
beyond
provided
followed
fabrication
techniques
(quasi-)spherical,
helical,
flexible,
wire-like,
biohybrid
MagRobots.
Applications
targeted
drug/gene
delivery,
cell
minimally
invasive
surgery,
biopsy,
biofilm
disruption/eradication,
imaging-guided
delivery/therapy/surgery,
pollution
removal
environmental
remediation,
(bio)sensing
also
reviewed.
Finally,
current
challenges
future
perspectives
development
magnetically
powered
miniaturized
motors
discussed.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
18, P. 213 - 227
Published: March 22, 2022
Regenerating
periodontal
bone
tissues
in
the
aggravated
inflammatory
microenvironment
under
diabetic
conditions
is
a
great
challenge.
Here,
polydopamine-mediated
graphene
oxide
(PGO)
and
hydroxyapatite
nanoparticle
(PHA)-incorporated
conductive
alginate/gelatin
(AG)
scaffold
developed
to
accelerate
regeneration
by
modulating
microenvironment.
PHA
confers
with
osteoinductivity
PGO
provides
pathway
for
scaffold.
The
promotes
transferring
endogenous
electrical
signals
cells
activating
Ca2+
channels.
Moreover,
nanomaterials
has
reactive
oxygen
species
(ROS)-scavenging
ability
anti-inflammatory
activity.
It
also
exhibits
an
immunomodulatory
that
suppresses
M1
macrophage
polarization
activates
M2
macrophages
secrete
osteogenesis-related
cytokines
mediating
glycolytic
RhoA/ROCK
pathways
macrophages.
induces
excellent
defects
of
rats
because
synergistic
effects
good
conductive,
ROS-scavenging,
anti-inflammatory,
abilities.
This
study
fundamental
insights
into
synergistical
conductivity,
osteoinductivity,
abilities
on
offers
novel
strategy
design
biomaterials
treatment
immune-related
diseases
tissue
regeneration.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(5)
Published: Nov. 24, 2021
Antiadhesion
barriers
such
as
films
and
hydrogels
used
to
wrap
repaired
tendons
are
important
for
preventing
the
formation
of
adhesion
tissue
after
tendon
surgery.
However,
sliding
can
compress
adjacent
hydrogel
barrier
cause
it
rupture,
which
may
then
lead
unexpected
inflammation.
Here,
a
self-healing
deformable
hyaluronic
acid
(HA)
is
constructed
peritendinous
antiadhesion
barrier.
Matrix
metalloproteinase-2
(MMP-2)-degradable
gelatin-methacryloyl
(GelMA)
microspheres
(MSs)
encapsulated
with
Smad3-siRNA
nanoparticles
entrapped
within
HA
inhibit
fibroblast
proliferation
prevent
adhesion.
GelMA
MSs
responsively
degraded
by
upregulation
MMP-2,
achieving
on-demand
release
siRNA
nanoparticles.
Silencing
effect
around
75%
toward
targeted
gene.
Furthermore,
shows
relatively
attenuated
inflammation
compared
non-healing
hydrogel.
The
mean
scores
composite
group
1.67
±
0.51
2.17
0.75
macroscopic
histological
evaluation,
respectively.
proposed
MMP-2-responsive
drug
behavior
highly
effective
decreasing
inhibiting
Therefore,
this
research
provides
new
strategy
development
safe
barriers.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Jan. 10, 2022
Abstract
Immune
response
and
new
tissue
formation
are
important
aspects
of
repair.
However,
only
a
single
aspect
is
generally
considered
in
previous
biomedical
interventions,
the
synergistic
effect
unclear.
Here,
dual-effect
coating
with
immobilized
immunomodulatory
metal
ions
(e.g.,
Zn
2+
)
osteoinductive
growth
factors
BMP-2
peptide)
designed
via
mussel
adhesion-mediated
ion
coordination
molecular
clicking
strategy.
Compared
to
bare
TiO
2
group,
can
increase
M2
macrophage
recruitment
by
up
92.5%
vivo
upregulate
expression
cytokine
IL-10
84.5%;
while
peptide
macrophages
124.7%
171%.
These
benefits
eventually
significantly
enhance
bone-implant
mechanical
fixation
(203.3
N)
bone
ingrowth
(82.1%)
compared
(98.6
N
45.1%,
respectively).
Taken
together,
be
utilized
synergistically
modulate
osteoimmune
microenvironment
at
interface,
enhancing
regeneration
for
successful
implantation.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(12), P. 5136 - 5174
Published: Jan. 1, 2022
Recent
years
have
witnessed
increasingly
rapid
advances
in
nanocarrier-based
biomedicine
aimed
at
improving
treatment
paradigms
for
cancer.
Nanogels
serve
as
multipurpose
and
constructed
vectors
formed
via
intramolecular
cross-linking
to
generate
drug
delivery
systems,
which
is
attributed
predominantly
their
satisfactory
biocompatibility,
bio-responsiveness,
high
stability,
low
toxicity.
Recently,
immunotherapy
has
experienced
unprecedented
growth
become
the
preferred
strategy
cancer
treatment,
mainly
involves
mobilisation
of
immune
system
an
enhanced
anti-tumour
immunity
tumour
microenvironment.
Despite
inspiring
success,
immunotherapeutic
strategies
are
limited
due
response
rates
immune-related
adverse
events.
Like
other
nanomedicines,
nanogels
comparably
by
lower
focal
enrichment
upon
introduction
into
organism
injection.
Because
three-dimensional
cross-linked
aqueous
materials
that
exhibit
similar
properties
natural
tissues
structurally
stable,
they
can
comfortably
cope
with
shear
forces
serum
proteins
bloodstream,
longer
circulation
life
increases
chance
nanogel
accumulation
tumour,
conferring
deep
penetration.
The
large
specific
surface
area
reduce
or
eliminate
off-target
effects
introducing
stimuli-responsive
functional
groups,
allowing
multiple
physical
chemical
modifications
purposes
improve
targeting
cell
subpopulations
organs,
increasing
bioavailability
drug,
a
events
on
therapies.
slow
release
reaching
site
facilitates
long-term
awakening
host's
system,
ultimately
achieving
therapeutic
effects.
As
effective
candidate
immunotherapy,
nanogel-based
been
widely
used.
In
this
review,
we
summarize
recent
deliver
immunomodulatory
small
molecule
drugs,
antibodies,
genes
cytokines,
target
antigen
presenting
cells,
form
vaccines,
enable
chimeric
receptor
(CAR)-T
therapy.
Future
challenges
well
expected
feasible
prospects
clinical
also
highlighted.
Acta Biomaterialia,
Journal Year:
2021,
Volume and Issue:
133, P. 168 - 186
Published: Aug. 18, 2021
The
regulatory
functions
of
the
immune
response
in
tissue
healing,
repair,
and
regeneration
have
been
evidenced
last
decade.
Immune
cells
play
central
roles
responses
toward
inducing
favorable
regenerative
processes.
Modulating
controlling
cell
(particularly
macrophages)
is
an
emerging
approach
to
enhance
regeneration.
Bioactive
glasses
(BGs)
are
multifunctional
materials
exhibiting
osteogenic,
angiogenic,
antibacterial
properties,
being
increasingly
investigated
for
various
scenarios,
including
bone
wound
healing.
On
other
hand,
immunomodulatory
effects
BGs
relation
regenerating
tissues
started
be
understood,
key
knowledge
emerging.
This
first
review
article
summarizing
repair
firstly
introduced,
discussing
potential
mechanisms
regarding
immunomodulation
induced
by
BGs.
Moreover,
interactions
between
involved
process
(dissolution
products)
summarized
detail.
Particularly,
a
well-regulated
timely
switch
macrophage
phenotype
from
pro-inflammatory
anti-inflammatory
crucial
constructive
through
modulating
osteogenesis,
osteoclastogenesis,
angiogenesis.
influence
BG
characteristics
on
discussed.
We
highlight
strategies
employed
harness
enhanced
regeneration,
incorporation
active
ions,
surface
functionalization,
controlled
release
molecules.
Finally,
we
conclude
with
our
perspectives
future
research
challenges
directions
field
Immunomodulatory
bioactive
healing
understood.
summarize
those
studies
which
focused
introduce
Interactions
processes
(and
their
dissolution
products,
biologically
ions)
elaborated.
modulate
enhancing
agents.
outlining
anticipate
that
increasing
efforts
will
start
emerge
area
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 10163 - 10178
Published: May 26, 2022
Excessive
extracellular
matrix
deposition
drives
fibroblasts
into
a
state
of
high
mechanical
stress,
exacerbating
pathological
fibrosis
and
hypertrophic
scar
formation,
leading
to
tissue
dysfunction.
This
study
reports
minimally
invasive
convenient
approach
obtaining
scarless
using
silk
fibroin
microneedle
patch
(SF
MNs).
We
found
that
by
tuning
the
MN
size
density
only,
biocompatible
MNs
significantly
decreased
elevation
index
in
rabbit
ear
model
increased
ultimate
tensile
strength
close
regular
skin.
To
advance
our
understanding
this
recent
approach,
we
built
fibroblast-populated
collagen
lattice
system
finite
element
MN-mediated
cellular
behavior
fibroblasts.
reduced
generated
contraction
as
indicated
expression
sensitive
gene
ANKRD1.
Specifically,
SF
attenuated
integrin-FAK
signaling
consequently
down-regulated
TGF-β1,
α-SMA,
I,
fibronectin.
It
resulted
low-stress
microenvironment
helps
reduce
formation
significantly.
Microneedles'
physical
intervention
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
27, P. 15 - 57
Published: March 27, 2023
Titanium
(Ti)
and
its
alloys
have
been
widely
used
as
orthopedic
implants,
because
of
their
favorable
mechanical
properties,
corrosion
resistance
biocompatibility.
Despite
significant
success
in
various
clinical
applications,
the
probability
failure,
degradation
revision
is
undesirably
high,
especially
for
patients
with
low
bone
density,
insufficient
quantity
or
osteoporosis,
which
renders
studies
on
surface
modification
Ti
still
active
to
further
improve
results.
It
discerned
that
physicochemical
properties
directly
influence
even
control
dynamic
interaction
subsequently
determines
rejection
implants.
Therefore,
it
crucial
endow
bulk
materials
specific
high
bioactivity
can
be
performed
by
realize
osseointegration.
This
article
first
reviews
characteristics
conventional
techniques
involving
mechanical,
physical
chemical
treatments
based
formation
mechanism
modified
coatings.
Such
methods
are
able
but
surfaces
static
state
cannot
respond
biological
cascades
from
living
cells
tissues.
Hence,
beyond
traditional
design,
responsive
avenues
then
emerging.
The
stimuli
sources
functionalization
originate
environmental
triggers
physiological
triggers.
In
short,
this
review
surveys
recent
developments
engineering
materials,
a
emphasis
advances
functionality,
provides
perspectives
improving
biocompatibility
