Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(22), P. 5506 - 5526

Published: Jan. 1, 2019

Cancer immunotherapy by educating or stimulating patients' own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic. However, although number of approved immunotherapeutics is rapidly increasing, key challenges such as limited clinical response rate and significant autoimmunity-related adverse effects remain be resolved. Recently, it been discovered that a diverse range biomaterials-assisted local treatment methods including localized radiotherapy, chemotherapy phototherapy are able stimulate systems, often inducing immunogenic cell death (ICD). The triggered tumor-specific immunological after treatments, especially combination with checkpoint blockade (ICB) therapy, can achieve abscopal effect whole-body spreading metastatic cells, later on result memory inhibit tumor recurrence. Moreover, delivery immunomodulatory therapeutics biomaterials also an alternative strategy improve reduce side immunotherapy. In this review, we would like summarize latest advances, opportunities utilizing strategies for enhancing anticancer immunity, discuss further prospects field together how may possibly translated into use.

Language: Английский

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Nanomaterials for T-cell cancer immunotherapy

Nature Nanotechnology, Journal Year: 2021, Volume and Issue: 16(1), P. 25 - 36

Published: Jan. 1, 2021

Language: Английский

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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Journal Year: 2019, Volume and Issue: 5, P. 100035 - 100035

Published: Nov. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Language: Английский

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Fighting Immune Cold and Reprogramming Immunosuppressive Tumor Microenvironment with Red Blood Cell Membrane-Camouflaged Nanobullets

ACS Nano, Journal Year: 2020, Volume and Issue: 14(12), P. 17442 - 17457

Published: Nov. 9, 2020

Nanomedicine, acting as the magic bullet, is capable of combining immunotherapy with other treatments to reverse a cold tumor (immune depletion) into hot tumor. However, how comprehensively inhibit immunosuppressive microenvironment (TME) remains major challenge for achieve maximum benefits. Thus, strategy that can simultaneously increase recruitment infiltrating lymphocytes (TILs) and reprogram TME still urgently needed. Herein, thermal-sensitive nitric oxide (NO) donor S-nitrosothiols (SNO)-pendant copolymer (poly(acrylamide-co-acrylonitrile-co-vinylimidazole)-SNO copolymer, PAAV-SNO) upper critical solution temperature (UCST) was synthesized employed fabricate an erythrocyte membrane-camouflaged nanobullet codelivery NIR II photothermal agent IR1061 indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor 1-methyl-tryptophan (1-MT). This multifunctional possessed long circulation in vivo, enhanced accumulation at site, therapeutics-controlled release by laser, thereby it could avoid unspecific drug leakage while enhancing biosecurity. More importantly, immunogenic cell death (ICD) induced local hyperthermia from therapy (PTT) be conducive increased CD8+ cytotoxic T (CTLs) site. Furthermore, through interfering IDO-1 activity 1-MT normalizing vessels situ generated NO, reprogrammed toward immunostimulatory phenotype, achieving excellent therapeutic efficacy against both primary breast cancer metastases. Collectively, this described study developed effective promising suppressive treat "immune cold" tumors.

Language: Английский

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Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(2), P. 787 - 797

Published: Jan. 5, 2022

Tumor-derived exosome can suppress dendritic cells (DCs) and T functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy clinical failure. Restored by antiexosomal PD-L1 tactic intensify ferroptosis tumor vice versa. Diminishing suppression establishing a nexus may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) an assembly semiconductor polymers encapsulating inducer (Fe3+) inhibitor (GW4869). The PFG MPNs elicited superior near-infrared II fluorescence/photoacoustic imaging tracking performance for precise photothermal therapy (PTT). PTT-augmented immunogenic cell death relieved silencing on DC maturation. GW4869 mediated based inhibition revitalized enhanced ferroptosis. This novel synergy PTT with evoked potent immunity B16F10 tumors immunological memory against metastatic lymph nodes.

Language: Английский

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RETRACTED: Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy

Chem, Journal Year: 2019, Volume and Issue: 5(7), P. 1892 - 1913

Published: June 17, 2019

Language: Английский

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Low-Temperature Photothermal Therapy: Strategies and Applications

Research, Journal Year: 2021, Volume and Issue: 2021

Published: Jan. 1, 2021

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells develop thermal resistance, and thus, efficacy PTT may dramatically decreased. In meantime, uncontrollable diffusion pose a threat surrounding healthy tissues. Recently, low-temperature (also known mild or mild-temperature PTT) demonstrated its remarkable capacity conquering these obstacles shown excellent performance bacterial elimination, wound healing, cancer treatments. Herein, we summarize recently proposed strategies for achieving based on nanomaterials introduce synthesis, characteristics, applications nanoplatforms. Additionally, combination other therapeutic modalities defeating cancers synergistic effect combined treatments are discussed. Finally, current limitations future directions inspiring more researchers make contributions promoting toward successful preclinical clinical disease

Language: Английский

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Niobium Carbide MXene Augmented Medical Implant Elicits Bacterial Infection Elimination and Tissue Regeneration

ACS Nano, Journal Year: 2020, Volume and Issue: 15(1), P. 1086 - 1099

Published: Dec. 29, 2020

Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic resistance are among the most dangerous threats for humans. With few effective strategies available in antimicrobial antibiofilm development, innovative methodologies inspired by advances other fields such as nanomedicine becoming more attractive to realize antibacterial agents. Herein, a 2D niobium carbide (Nb2C) MXene titanium plate (Nb2C@TP)-based clinical implant with practical multimodal anti-infection functions was developed. Such emerging modes capable of destroying biofilms direct bacteria elimination through down-regulating energy metabolism pathways, suppressing biofilm formation, enhancing as-formed detachment via an activating accessory gene regulator. Another intriguing feature this is sensitization ability toward photothermal transduction, which reduces temperature necessary eradication mitigates possible normal tissue damage. Moreover, Nb2C@TP medical able alleviate proinflammatory responses scavenging excessive reactive oxygen species infectious microenvironments, benefiting angiogenesis remodeling.

Language: Английский

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Biodegradable titanium nitride MXene quantum dots for cancer phototheranostics in NIR-I/II biowindows

Chemical Engineering Journal, Journal Year: 2020, Volume and Issue: 400, P. 126009 - 126009

Published: June 23, 2020

Language: Английский

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Recent strategies for nano-based PTT combined with immunotherapy: from a biomaterial point of view

Theranostics, Journal Year: 2021, Volume and Issue: 11(15), P. 7546 - 7569

Published: Jan. 1, 2021

Cancer has been a great threat to humans for decades. Due the limitations of monotherapy, combinational therapies such as photothermal therapy (PTT) and immunotherapy have gained increasing attention with expectation overcome shortfalls each other obtain satisfactory therapeutic outcomes. PTT can inhibit primary tumors by thermal ablation but usually fails achieve complete eradication cannot prevent metastasis recurrence. Meanwhile, efficacy is attenuated weak immunogenicity tumor immunosuppressive microenvironment (ITM). Therefore, many recent studies attempted synergize in order enhance efficacy. In this review, we aim summarize cutting-edge strategies combining nano-based cancer treatment. Herein, combination were mainly classified into four categories, including 1) combined antigens induce host immune responses; 2) adjuvants acting

Language: Английский

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