Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907
Published: May 12, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication
Language: Английский
Citations
125
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 513 - 534
Published: April 1, 2024
Language: Английский
Citations
116
Nano Today, Journal Year: 2023, Volume and Issue: 51, P. 101911 - 101911
Published: June 16, 2023
Language: Английский
Citations
97
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(13), P. 7205 - 7217
Published: March 23, 2023
The desirable curative effect in clinical immunotherapy has been challenging due to the immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism solid tumors. Although targeting metabolic reprogramming of cells can restore survival and function immune TME, it is also plagued by insufficient immunogenicity. Herein, an activatable immunomodulatory nanoadjuvant CuSe/CoSe2@syrosingopine (CSC@Syro) constructed for simultaneously relieving TME boosting response. Specifically, CuSe/CoSe2 (CSC) exhibits TME-activated glutathione (GSH) depletion hydroxyl radical (•OH) generation potential ferroptosis. Meanwhile, remarkable photothermal conversion efficiency elevated photocatalytic ROS level both promote CSC heterostructures induce robust immunogenic cell death (ICD). Besides, loaded syrosingopine inhibitor achieves LA blockade cancer downregulating expression monocarboxylate transporter 4 (MCT4), which could sensitize ferroptosis intracellular milieu acidification neutralize acidic alleviate immunosuppression. Hence, advanced modulation confers potentiated infiltration ICD-stimulated T lymphocytes further reinforces antitumor therapy. In brief, CSC@Syro-mediated synergistic therapy elicit potent immunogenicity suppress proliferation metastasis effectually integrating regulation immunotherapy.
Language: Английский
Citations
96
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Sept. 2, 2023
Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable triggering both ferroptosis remains limited. Here we show construction a covalent organic framework (COF-919) from planar twisted AIEgen-based motifs dual-inducer for efficient Mechanistic studies reveal that COF-919 displays stronger near-infrared light absorption, lower band energy, longer lifetime to favor generation reactive oxygen species (ROS) photothermal conversion, pyroptosis. Because its good ROS production capability, it upregulates intracellular lipid peroxidation, leading glutathione depletion, low expression peroxidase 4, induction ferroptosis. Additionally, by effectively inhibits tumor metastasis recurrence, resulting in over 90% growth inhibition cure rates exceeding 80%.
Language: Английский
Citations
95
Exploration, Journal Year: 2023, Volume and Issue: 3(5)
Published: June 30, 2023
Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application
Language: Английский
Citations
94
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821
Published: April 9, 2023
Language: Английский
Citations
87
Advanced Science, Journal Year: 2022, Volume and Issue: 9(34)
Published: Oct. 17, 2022
Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.
Language: Английский
Citations
82
Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(18)
Published: Feb. 17, 2022
Abstract Radiotherapy (RT) is hampered by the limited oxygen in tumors, which could be potentiated via reprogramming metabolism and increasing utilization efficiency. Herein, a metal‐phenolic nanosensitizer (Hf‐PSP‐DTC@PLX) was integrated an acid‐sensitive hydrogen sulfide (H 2 S) donor (polyethylene glycol‐co‐polydithiocarbamates, PEG‐DTC) hafnium‐chelated polyphenolic semiconducting polymer (Hf‐PSP) amphiphilic (poloxamer F127, PLX). Hf‐PSP‐DTC@PLX elicited high imaging performance for precise RT generated H S to reduce cellular consumption rate mitochondrial respiration inhibition, reprogrammed improvement of tumor oxygenation. Then, Hf‐sensitization fully utilize well‐preserved intensify efficacy activate immunogenicity. Such synergistic strategy oxygenation would have great potential optimizing oxygen‐dependent therapeutics.
Language: Английский
Citations
77
Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135661 - 135661
Published: March 7, 2022
Language: Английский
Citations
77