Nano Select,
Journal Year:
2021,
Volume and Issue:
3(4), P. 792 - 828
Published: Oct. 13, 2021
Abstract
Gold
nanoparticles
(GNPs)
have
been
extensively
used
in
various
applications
ranging
from
environmental
detection
to
biomedical
applications.
Due
their
unique
characteristics
such
as
tunable
surface
properties
well
plasmon
resonance
(SPR),
GNPs
garnered
attention
exclusively
therapy
and
diagnostics.
Their
ease
of
synthesis
compatibility
with
functionalizing
ligands
has
made
them
efficient
a
robust
platform.
flexibility
functionalization,
profoundly
cancer
treatment
as,
antiviral,
antibacterial
agents.
In
addition,
owing
possessing
optical
properties,
utilized
molecular
imaging
contrast
agent.
This
article
discusses
highlights
special
that
exploited
recent
years
improve
research
field
nuclear
medicine,
agent,
vaccine
development,
medical
implant,
diagnostics,
biosensing,
lab‐on‐chip
Moreover,
size
dependent
biocompatibility,
biodistribution,
excreation
was
discussed
details
for
vivo
At
the
forefront
modern
theraputic
technology,
based
antiviral
agents
great
potential
which
is
also
highlighted
briefly
this
article.
current
state
ongoing
clinical
trials
challenges
associated
regulatory
approval
are
explored.
Lastly,
sheds
light
on
findings
toxicity
prospects
future
direct
research.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(18)
Published: Feb. 1, 2021
Abstract
Current
treatments
for
chronic
diabetic
wounds
remain
unsatisfactory
due
to
the
lack
of
ideal
wound
dressings
that
can
integrate
matching
mechanical
strength,
fast
self‐healability,
facile
dressing
change,
and
multiple
therapeutic
effects
into
one
system.
In
this
work,
benefiting
from
catechol
groups
effect
epigallocatechin‐3‐gallate
(EGCG,
green
tea
derivative),
a
smart
hydrogel
be
conveniently
obtained
through
copolymerization
complex
formed
by
EGCG
3‐acrylamido
phenylboronic
acid
(APBA)
(the
formation
boronate
ester
bond)
acrylamide.
The
resulting
features
adequate
properties,
self‐healing
capability,
tissue
adhesiveness.
Otherwise,
substantial
release
not
only
realize
anti‐oxidation,
antibacterial,
anti‐inflammatory
proangiogenic
effect,
modulation
macrophage
polarization
accelerate
healing,
but
also
facilitate
easy
change.
This
advanced
provides
effective
way
management
may
extended
therapy
other
complicated
healings.
Materials Horizons,
Journal Year:
2021,
Volume and Issue:
8(6), P. 1618 - 1633
Published: Jan. 1, 2021
This
review
focuses
on
the
recent
progress
in
polydopamine
antibacterial
materials,
including
their
structural
and
functional
features,
preparation
strategies,
mechanisms,
biomedical
applications.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 1708 - 1733
Published: Jan. 20, 2022
Wound
dressings
based
on
nanomaterials
play
a
crucial
role
in
wound
treatment
and
are
widely
used
whole
range
of
medical
settings,
from
minor
to
life-threatening
tissue
injuries.
This
article
presents
an
educational
review
the
accumulating
knowledge
this
multidisciplinary
area
lay
out
challenges
opportunities
that
lie
ahead
ignite
further
faster
development
clinically
valuable
technologies.
The
analyzes
functional
advantages
nanomaterial-based
gauzes
hydrogels
as
well
hybrid
structures
thereof.
On
basis,
state-of-the-art
advances
transfer
(semi)blind
approaches
evaluation
state
smart
enable
real-time
monitoring
diagnostic
functions
could
help
during
healing.
explores
translation
related
aspects
into
real-world
use.
ongoing
future
associated
with
clinical
decisions
presented
reviewed.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
17(3), P. 353 - 384
Published: Jan. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(30), P. 34455 - 34469
Published: July 20, 2022
Engineered
wound
dressing
materials
with
excellent
injectability,
self-healing
ability,
tissue-adhesiveness,
especially
the
ones
possessing
potential
therapeutic
effects
have
great
practical
significance
in
healthcare.
Herein,
an
injectable
quaternary
ammonium
chitosan
(QCS)/tannic
acid
(TA)
hydrogel
based
on
QCS
and
TA
was
designed
fabricated
by
facile
mixing
of
two
ingredients
under
physiological
conditions.
In
this
system,
hydrogels
were
mainly
cross-linked
dynamic
ionic
bonds
hydrogen
between
TA,
which
endows
injectable,
self-healing,
adhesive
properties.
Benefitting
from
inherent
antioxidative,
antibacterial,
hemostatic
abilities
QCS,
showed
superior
reactive
oxygen
species
scavenging
activity,
broad-spectrum
antibacterial
as
well
rapid
capability.
Moreover,
QCS/TA2.5
(containing
2.5%
TA)
exhibited
biocompatibility.
The
vivo
experiments
also
that
not
only
rapidly
stopped
bleeding
arterial
deep
incompressible
wounds
mouse
tail
amputation,
femoral
artery
hemorrhage,
liver
incision
models
but
significantly
accelerated
healing
a
full-thickness
skin
model.
For
potentials
listed
above,
multifunctional
offers
promising
network
material
for
both
hemostasis
repair.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(48)
Published: Oct. 28, 2020
Abstract
Nanomaterials
with
intrinsic
enzyme‐like
activities,
namely
“nanozymes,”
are
showing
increasing
potential
as
a
new
type
of
broad‐spectrum
antibiotics.
However,
their
feasibility
is
still
far
from
satisfactory,
due
to
low
catalytic
activity,
poor
bacterial
capturing
capacity,
and
complicated
material
design.
Herein,
facile
synthesis
defect‐rich
adhesive
molybdenum
disulfide
(MoS
2
)/rGO
vertical
heterostructure
(VHS)
through
one‐step
microwave‐assisted
hydrothermal
method
reported.
This
simple,
convenient
but
effective
for
rapid
enables
extremely
uniform
well‐dispersed
MoS
/rGO
VHS
abundant
S
Mo
vacancies
rough
surface,
performance
approaching
the
requirements
practical
application.
It
demonstrated
experimentally
theoretically
that
as‐prepared
possesses
defect
irradiation
dual‐enhanced
triple
activities
(oxidase,
peroxidase,
catalase)
promoting
free‐radical
generation,
owing
much
more
active
edge
sites
exposure.
Meanwhile,
VHS‐achieved
surface
exhibits
excellent
capacity
capture,
elevated
reactive
oxygen
species
(ROS)
destruction
local
topological
interactions.
As
result,
optimized
efficacy
against
drug‐resistant
Gram‐negative
Gram‐positive
bacteria
can
be
explored
by
such
nanozymes,
demonstrating
simple
powerful
way
engineered
nanozymes
alternative
