Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)

Published: Jan. 31, 2023

Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention

Language: Английский

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Advances in organophosphorus pesticides pollution: Current status and challenges in ecotoxicological, sustainable agriculture, and degradation strategies

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127494 - 127494

Published: Oct. 14, 2021

Language: Английский

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Dietary fiber‐derived short‐chain fatty acids: A potential therapeutic target to alleviate obesity‐related nonalcoholic fatty liver disease

Obesity Reviews, Journal Year: 2021, Volume and Issue: 22(11)

Published: July 18, 2021

Summary Over the past several decades, increasing global prevalence of obesity‐related nonalcoholic fatty liver disease (NAFLD) has been one main challenges to human health. Recently, evidence validated connections among short chain acids (SCFAs), a physiologically relevant concentration, intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs metabolism in relation NAFLD pathophysiology, focusing on recent advances. Firstly, how are generated absorbed under different nutritional conditions gut. Secondly, maintain gut barrier alleviate hepatic inflammatory responses. Thirdly, energy balance through controlling appetite mediating glucose homeostasis at systemic level. Fourthly, G‐protein‐coupled receptors (GPRs) widely involved above metabolic processes regulated by SCFAs. Overall, review aimed provide new insights into prospects as potential therapeutic target management diseases.

Language: Английский

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Physiological Functions of Threonine in Animals: Beyond Nutrition Metabolism

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2592 - 2592

Published: July 28, 2021

Threonine (Thr), an essential amino acid for animals and the limiting in swine poultry diets, which plays a vital role modulation of nutritional metabolism, macromolecular biosynthesis, gut homeostasis. Current evidence supports that supplementation Thr leads to benefits terms energy metabolism. is not only important component gastrointestinal mucin, but also acts as modulator influences intestinal immune system via complex signaling networks, particularly mitogen-activated protein kinase (MAPK) target rapamycin (TOR) signal pathway. recognized indispensable nutrient cell growth proliferation. Hence, optimization requirement may exert favorable impact on factors linked health diseases animals. This review focuses latest reports metabolic pathways regulation, well relationship between relevant physiological functions.

Language: Английский

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Enterotoxigenic Escherichia coli : intestinal pathogenesis mechanisms and colonization resistance by gut microbiota

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: March 31, 2022

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and travelers developing countries. ETEC characterized by the ability to produce virulence factors including colonization (CFs) enterotoxins, that bind specific receptors on epithelial cells induce diarrhea. The gut microbiota stable sophisticated ecosystem performs range beneficial functions for host, protection against pathogen colonization. Understanding pathogenic mechanisms interaction between represents not only research need but also an opportunity challenge develop precautions infection. Herein, this review focuses recent discoveries about etiology, pathogenesis clinical manifestation, discusses resistances mediated microbiota, as well preventative strategies with aim provide novel insights can reduce adverse effect human health.

Language: Английский

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Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 193, P. 114670 - 114670

Published: Dec. 17, 2022

Language: Английский

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Review on plant-derived bioactive peptides: biological activities, mechanism of action and utilizations in food development

Journal of Future Foods, Journal Year: 2022, Volume and Issue: 2(2), P. 143 - 159

Published: May 26, 2022

Plant proteins are good alternative to animal sources in bioactive peptide production due their safety, low-cost, rich resources and easy for large scale production. The bioactivities of the peptides derived from plant including antihypertensive, hypocholesterolemic, immunomodulatory, antioxidant, antimicrobial, anti-diabetic, opiate hepatoprotective effect being increasingly recognized with regards health promoting disease prevention. In addition bioactivities, plant-derived possess various functional properties emulsifying foaming properties, water oil retention capacities owning hydrophilic/lipophilic property, conformational flexibility chain length peptides. Hence, promising ingredients development health-care products. This review provides research progress on biological activities mechanism action structure-activity relationships were also described, when known. Furthermore, recent developments, major challenges prospect application plant-derive products discussed summarized. objective this is improve understanding peptides, provide some constructive inspirations further industrial food medicine industry.

Language: Английский

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Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis

iMeta, Journal Year: 2022, Volume and Issue: 1(4)

Published: Sept. 27, 2022

Abstract Intestinal epithelium undergoes rapid cellular turnover, relying on the local niche, to support intestinal stem cells (ISCs) function and self‐renewal. Research into association between ISCs disease continues expand at a rate. However, detailed interaction of gut microbes remains be elucidated. Thus, this review witnessed major advances in crosstalk microbes, delivering key insights (1) construction ISC niche molecular mechanism how jointly govern epithelial homeostasis protect against diseases with participation Wnt, bone morphogenetic protein, Notch; (2) differentiation fate affect microbiota. Meanwhile, presence also regulates function; (3) microbiota regulation by Wnt Notch signals through pattern recognition receptors; (4) do specific microbiota‐related postbiotics influence maintain regeneration that provide promising alternative therapeutic method for diseases. Considering is still unclear, it necessary further explore regulatory role utilize alleviate disorders. Furthermore, these collectively drive us ever closer breakthroughs regenerative medicine cancer treatment microbial transplantation clinic.

Language: Английский

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Mycotoxins in food and feed: toxicity, preventive challenges, and advanced detection techniques for associated diseases

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(27), P. 8489 - 8510

Published: April 21, 2022

Mycotoxins are produced primarily as secondary fungal metabolites. toxic in nature and naturally by various species of fungi, which usually contaminate food feed ingredients. The growth these harmful fungi depends on several environmental factors, such pH, humidity, temperature; therefore, the mycotoxin distribution also varies among global geographical areas. Various rules regulations regarding mycotoxins imposed government bodies each country, responsible for addressing health security concerns. Despite this legislation, incidence contamination is continuously increasing. In review, we discuss regulatory guidelines recommendations that implemented around world to control products. Researchers inventors from parts have reported innovations controlling mycotoxin-associated consequences. Unfortunately, most techniques restricted laboratory scales cannot reach users. Consequently, date, no single device has been commercialized can detect all available environment. Therefore, study, describe severe hazards associated with exposure, their molecular signaling pathways processes toxicity, genotoxic cytotoxic effects toward humans animals. We recent developments construction a sensitive specific effectively implements identification detection methods. addition, our study comprehensively examines advancements field mitigating consequences links them activated upon exposure.

Language: Английский

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Natural antimicrobials from plants: Recent advances and future prospects

Food Chemistry, Journal Year: 2023, Volume and Issue: 432, P. 137231 - 137231

Published: Aug. 24, 2023

Language: Английский

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