Scaffolding Biomaterials for 3D Cultivated Meat: Prospects and Challenges

Advanced Science, Journal Year: 2021, Volume and Issue: 9(3)

Published: Nov. 16, 2021

Abstract Cultivating meat from stem cells rather than by raising animals is a promising solution to concerns about the negative externalities of production. For cultivated fully mimic conventional meat's organoleptic and nutritional properties, innovations in scaffolding technology are required. Many technologies already developed for use biomedical tissue engineering. However, production comes with unique set constraints related scale cost as well necessary attributes final product, such texture food safety. This review discusses properties vertebrate skeletal muscle that will need be replicated successful product current state innovation within industry, highlighting scaffold materials techniques can applied development. Recommendations provided future research into scaffolds capable supporting growth high‐quality while minimizing costs. Although development appropriate challenging, it also tractable provides novel opportunities customize properties.

Language: Английский

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Acoustofluidics for biomedical applications

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: April 21, 2022

Language: Английский

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Emerging Technologies in Multi‐Material Bioprinting

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(49)

Published: Oct. 1, 2021

Bioprinting, within the emerging field of biofabrication, aims at fabrication functional biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell-laden bioinks. However, single-material oftentimes fail reproduce complex compositions and diversity native tissues. Multi-material as an approach enables heterogeneous multi-cellular constructs that replicate their host microenvironments better than approaches. Here, modalities are reviewed, being multi-material is discussed, advantages challenges, encompassing both custom-designed commercially available technologies analyzed. A perspective how opens up new opportunities for tissue engineering, model therapeutics development, personalized medicine offered.

Language: Английский

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Ultrasound-Responsive Systems as Components for Smart Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(5), P. 5165 - 5208

Published: Nov. 12, 2021

Smart materials can respond to stimuli and adapt their responses based on external cues from environments. Such behavior requires a way transport energy efficiently then convert it for use in applications such as actuation, sensing, or signaling. Ultrasound carry safely with low losses through complex opaque media. It be localized small regions of space couple systems over wide range time scales. However, the same characteristics that allow ultrasound propagate make difficult acoustic into other useful forms. Recent work across diverse fields has begun address this challenge, demonstrating ultrasonic effects provide control physical chemical surprisingly high specificity. Here, we review recent progress ultrasound-matter interactions, focusing incorporated components smart materials. These techniques build fundamental phenomena cavitation, microstreaming, scattering, radiation forces enable capabilities payload delivery, initiation biological processes. The diversity emerging holds great promise supported by poses interesting questions further investigations.

Language: Английский

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High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

Nano Research, Journal Year: 2023, Volume and Issue: 16(2), P. 3475 - 3515

Published: Jan. 3, 2023

Language: Английский

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Design of Acoustic/Elastic Phase Gradient Metasurfaces: Principles, Functional Elements, Tunability, and Coding

Applied Mechanics Reviews, Journal Year: 2022, Volume and Issue: 74(2)

Published: March 1, 2022

Abstract Acoustic/elastic metasurfaces as a kind of two-dimensional metamaterials are subwavelength thickness and show remarkable ability acoustic/elastic wave manipulation. They have potential applications in various fields such acoustic imaging, communications, cloaking, camouflage, vibration/noise control, energy harvesting, nondestructive testing. In this review, we mainly summarize recent developments phase gradient metasurfaces, including design principles, functional elements, field manipulation with applications, tunable well the emerging digital coding metasurfaces. At last, outline future research directions field.

Language: Английский

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Ultrasound technology and biomaterials for precise drug therapy

Materials Today, Journal Year: 2023, Volume and Issue: 63, P. 210 - 238

Published: Jan. 9, 2023

Language: Английский

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Compact holographic sound fields enable rapid one-step assembly of matter in 3D

Science Advances, Journal Year: 2023, Volume and Issue: 9(6)

Published: Feb. 8, 2023

Acoustic waves exert forces when they interact with matter. Shaping ultrasound fields precisely in 3D thus allows control over the force landscape and should permit particulates to fall into place potentially form whole objects "one shot." This is promising for rapid prototyping, most notably biofabrication, since conventional methods are typically slow apply mechanical or chemical stress on biological cells. Here, we realize generation of compact holographic demonstrate one-step assembly matter using acoustic forces. We combine multiple that drive contactless solid microparticles, hydrogel beads, cells inside standard labware. The structures can be fixed via gelation surrounding medium. In contrast previous work, this approach handles positive does not require opposing waves, supporting surfaces scaffolds. envision applications tissue engineering additive manufacturing.

Language: Английский

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Biomolecular actuators for genetically selective acoustic manipulation of cells

Science Advances, Journal Year: 2023, Volume and Issue: 9(8)

Published: Feb. 22, 2023

The ability to physically manipulate specific cells is critical for the fields of biomedicine, synthetic biology, and living materials. Ultrasound has with high spatiotemporal precision via acoustic radiation force (ARF). However, because most have similar properties, this capability disconnected from cellular genetic programs. Here, we show that gas vesicles (GVs)-a unique class gas-filled protein nanostructures-can serve as genetically encodable actuators selective manipulation. Because their lower density higher compressibility relative water, GVs experience strong ARF opposite polarity other When expressed inside cells, invert cells' contrast amplify magnitude ARF, allowing be selectively manipulated sound waves based on genotype. provide a direct link between gene expression acoustomechanical actuation, opening paradigm control in broad range contexts.

Language: Английский

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Microscale acoustic streaming for biomedical and bioanalytical applications

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 160, P. 116958 - 116958

Published: Feb. 4, 2023

Language: Английский

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