Emerging Strategies in Enhancing Singlet Oxygen Generation of Nano-Photosensitizers Toward Advanced Phototherapy DOI Creative Commons
Mohammad Tavakkoli Yaraki, Bin Liu, Yen Nee Tan

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 5, 2022

Abstract The great promise of photodynamic therapy (PDT) has thrusted the rapid progress developing highly effective photosensitizers (PS) in killing cancerous cells and bacteria. To mitigate intrinsic limitations classical molecular photosensitizers, researchers have been looking into designing new generation nanomaterial-based (nano-photosensitizers) with better photostability higher singlet oxygen (SOG) efficiency, ways enhancing performance existing photosensitizers. In this paper, we review recent development nano-photosensitizers nanoplasmonic strategies to enhance SOG efficiency for PDT performance. Firstly, explain mechanism reactive species by followed a brief discussion on commercially available their PDT. We then introduce three types that can effectively produce molecules under visible light illumination, i.e., aggregation-induced emission nanodots, metal nanoclusters (< 2 nm), carbon dots. Different design approaches synthesize these were also discussed. further rate nano-photosensitizers, plasmonic using different nanoparticles both colloidal planar metal-PS systems are reviewed. key parameters determine metal-enhanced (ME-SOG) underlined enhancement Lastly, highlight future prospects nanoengineering strategies, discuss how nanobiotechnology theoretical simulation could accelerate ME-SOG image-guided therapy.

Language: Английский

Aggregation‐Induced Emission: New Vistas at the Aggregate Level DOI
Zheng Zhao, Haoke Zhang, Jacky W. Y. Lam

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 9888 - 9907

Published: Feb. 12, 2020

Aggregation-induced emission (AIE) describes a photophysical phenomenon in which molecular aggregates exhibit stronger than the single molecules. Over course of last 20 years, AIE research has made great strides material development, mechanistic study and high-tech applications. The achievements demonstrate that show many properties functions are absent species. In this review, we summarize advances field its related areas. We specifically focus on new materials attained by beyond microscopic level. hope review will inspire more into ensembles at meso level lead to significant progress biological science.

Language: Английский

Citations

1152

Design of superior phototheranostic agents guided by Jablonski diagrams DOI
Guangxue Feng, Guoqiang Zhang, Dan Ding

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

Citations

593

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy DOI
Zhijun Zhang, Wenhan Xu,

Miaomiao Kang

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(36)

Published: July 21, 2020

Abstract Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, optimum use dissipated energy through both radiative nonradiative pathways is definitely appealing, yet a significantly challenging task. To best knowledge, there have been no previous reports on single molecular species effective at affording all phototheranostic modalities including fluorescence (FLI), photoacoustic (PAI), photothermal (PTI), photodynamic therapy (PDT), (PTT). Herein, simple highly powerful one‐for‐all based aggregation‐induced emission (AIE)‐active fluorophores tactfully designed constructed. Thanks its strong electron donor–acceptor interaction finely modulated intramolecular motion, AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) emission, efficient reactive oxygen generation, high conversion efficiency upon NIR irradiation, indicating actualization balance between dissipations. Furthermore, unprecedented performance NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT demonstrated by precise tumor diagnosis complete elimination outcomes. This study thus brings new insight into development superior for practical cancer theranostics.

Language: Английский

Citations

372

Recent advances of AIE light-up probes for photodynamic therapy DOI Creative Commons
Shanshan Liu, Guangxue Feng, Ben Zhong Tang

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 12(19), P. 6488 - 6506

Published: Jan. 1, 2021

AIE fluorogens provide new opportunities for the development of light-up probes photodynamic therapy.

Language: Английский

Citations

303

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death DOI
Pan Zheng, Binbin Ding, Zhongyu Jiang

et al.

Nano Letters, Journal Year: 2021, Volume and Issue: 21(5), P. 2088 - 2093

Published: Feb. 17, 2021

Immunogenic cell death (ICD), a manner of tumor that can trigger antitumor immune responses, has received extensive attention as potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca2+) nanomodulators have been developed therapy through mitochondrial Ca2+ overload, their ICD-inducing properties not explored. Herein, an acid-sensitive PEG-decorated carbonate (CaCO3) nanoparticle incorporating curcumin (CUR; enhancer) (PEGCaCUR) was prepared using simple one-pot strategy. PEGCaCUR served only nanomodulator inducing efficient overload but also ICD inducer during improved therapy. Combination with ultrasound (US), PEGCaCUR+US, led to enhanced effect attributable the along subsequent upregulation reactive oxygen species levels. facilitates photoacoustic/fluorescence dual-mode imaging, well effectively suppressing growth and metastasis, indicating promising theranostic properties.

Language: Английский

Citations

300

Photodynamic therapy for hypoxic tumors: Advances and perspectives DOI
Huang Li,

Shaojing Zhao,

Jiasheng Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 438, P. 213888 - 213888

Published: March 16, 2021

Language: Английский

Citations

260

Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery DOI
Chao Chen, Xiang Ni,

Han‐Wen Tian

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 10008 - 10012

Published: Jan. 25, 2020

Abstract Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing thermal deactivation, enabling absorbed excitation to mostly focus on fluorescence emission. The co‐assembly amphiphiles AIEgens affords highly emissive supramolecular AIE nanodots thanks their interaction severely restricting intramolecular motion AIEgens, which also show negligible generation cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such dots have rather low in side toxicity serve as superior fluorescent bioprobe for ultrasensitive image‐guided cancer surgery.

Language: Английский

Citations

251

Gathering brings strength: How organic aggregates boost disease phototheranostics DOI
Ji Qi, Hanlin Ou, Qian Liu

et al.

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

Citations

251

A Multichannel Ca2+ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy DOI
Pan Zheng, Binbin Ding,

Run Shi

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(15)

Published: March 6, 2021

Subcellular organelle-targeted nanoformulations for cancer theranostics are receiving increasing attention owing to their benefits of precise drug delivery, maximized therapeutic index, and reduced off-target side effects. Herein, a multichannel calcium ion (Ca

Language: Английский

Citations

251

Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress DOI Creative Commons

Zeyan Zhuang,

Jun Dai,

Maoxing Yu

et al.

Chemical Science, Journal Year: 2020, Volume and Issue: 11(13), P. 3405 - 3417

Published: Jan. 1, 2020

Photodynamic therapy (PDT) is considered a pioneering and effective modality for cancer treatment, but it still facing challenges of hypoxic tumors. Recently, Type I PDT, as an strategy to address this issue, has drawn considerable attention. Few reports are available on the capability reactive oxygen species (ROS) generation purely organic photosensitizers (PSs). Herein, we report two new PSs, α-TPA-PIO β-TPA-PIO, from phosphindole oxide-based isomers with efficient ROS abilities. A detailed study photophysical photochemical mechanisms conducted shed light molecular design PSs based mechanism. The in vitro results demonstrate that these can selectively accumulate neutral lipid region, particularly endoplasmic reticulum (ER), cells efficiently induce ER-stress mediated apoptosis autophagy PDT. In vivo models indicate β-TPA-PIO successfully achieves remarkable tumor ablation. ROS-based ER stress triggered by β-TPA-PIO-mediated PDT high potential precursor immunostimulatory effect immunotherapy. This work presents comprehensive protocol I-based highlights significance considering working mechanism optimization treatment protocols.

Language: Английский

Citations

242