Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(22), P. 8179 - 8234
Published: Jan. 1, 2020
Phototheranostics
represents
a
promising
direction
for
modern
precision
medicine,
which
has
recently
attracted
great
research
interest
from
multidisciplinary
areas.
Organic
optical
agents
including
small
molecular
fluorophores,
semiconducting/conjugated
polymers,
aggregation-induced
emission
luminogens,
etc.
with
tuneable
photophysical
properties,
high
biosafety
and
biocompatibility,
facile
processability
ease
of
functionalization
have
delivered
encouraging
performance
in
disease
phototheranostics.
This
review
summarizes
the
recent
progress
organic
phototheranostic
an
emphasis
on
main
strategies
to
manipulate
three
excitation
energy
dissipation
pathways,
namely,
radiative
decay,
thermal
deactivation,
intersystem
crossing,
assistance
Jablonski
diagram,
particularly
showcases
how
diagram
been
guiding
design
molecule
aggregate
levels
promote
outcomes.
Molecular
nanoengineering
modulate
processes
convert
absorbed
photons
into
fluorescent/phosphorescent/photoacoustic
signals
and/or
photodynamic/photothermal
curing
effects
improved
phototheranostics
are
elaborated.
Noteworthily,
adaptive
activatable
transformable
functions
demand,
regulation
such
as
chemiexcitation
efficacies
also
included.
A
brief
summary
discussion
current
challenges
future
perspectives
this
field
is
further
presented.
Aggregate,
Journal Year:
2020,
Volume and Issue:
1(1), P. 80 - 106
Published: Dec. 1, 2020
Abstract
Theranostics
referring
to
the
ingenious
integration
of
diagnostics
and
therapeutics
has
garnered
tremendous
attention
in
these
years
as
it
provides
a
promising
opportunity
for
modern
personalized
precision
medicine.
By
virtue
good
biocompatibility,
outstanding
fluorescence
property,
easy
processability
functionalization,
promoted
photosensitizing
efficiency,
well
facile
construction
multi‐modality
theranostics,
fluorophores
with
aggregation‐induced
emission
(AIE)
characteristics
exhibit
inexhaustible
vigorous
vitality
field
theranostics.
Numerous
significant
breakthroughs
state‐of‐the‐art
progression
have
been
witnessed
past
few
years.
This
review
highlights
aggregation‐enhanced
superiorities
AIE
luminogens
(AIEgens)
disease
theranostics
mainly
involving
diagnostic
imaging
(fluorescence
room
temperature
phosphorescence),
therapeutic
intervention
(photodynamic
therapy),
feasibility
based
on
experimental
measurements
theoretical
simulations.
Additionally,
latest
advanced
developments
AIEgens
aspect
corresponding
strategies
design
highly
effective
AIE‐active
through
triggering
aggregation
formation
are
comprehensively
summarized.
Moreover,
brief
conclusion
discussion
current
challenges
future
perspectives
this
area
is
further
presented.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(36)
Published: July 21, 2020
Abstract
Aiming
to
achieve
versatile
phototheranostics
with
the
integrated
functionalities
of
multiple
diagnostic
imaging
and
synergistic
therapy,
optimum
use
dissipated
energy
through
both
radiative
nonradiative
pathways
is
definitely
appealing,
yet
a
significantly
challenging
task.
To
best
knowledge,
there
have
been
no
previous
reports
on
single
molecular
species
effective
at
affording
all
phototheranostic
modalities
including
fluorescence
(FLI),
photoacoustic
(PAI),
photothermal
(PTI),
photodynamic
therapy
(PDT),
(PTT).
Herein,
simple
highly
powerful
one‐for‐all
based
aggregation‐induced
emission
(AIE)‐active
fluorophores
tactfully
designed
constructed.
Thanks
its
strong
electron
donor–acceptor
interaction
finely
modulated
intramolecular
motion,
AIE
fluorophore‐based
nanoparticles
simultaneously
exhibit
bright
near‐infrared
II
(NIR‐II)
emission,
efficient
reactive
oxygen
generation,
high
conversion
efficiency
upon
NIR
irradiation,
indicating
actualization
balance
between
dissipations.
Furthermore,
unprecedented
performance
NIR‐II
FLI‐PAI‐PTI
trimodal‐imaging‐guided
PDT–PTT
demonstrated
by
precise
tumor
diagnosis
complete
elimination
outcomes.
This
study
thus
brings
new
insight
into
development
superior
for
practical
cancer
theranostics.
Aggregate,
Journal Year:
2021,
Volume and Issue:
2(1), P. 95 - 113
Published: Jan. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(9), P. 9032 - 9077
Published: March 21, 2022
Cucurbit[n]urils
(Q[n]s
or
CB[n]s),
as
a
classical
of
artificial
organic
macrocyclic
hosts,
were
found
to
have
excellent
advantages
in
the
fabricating
tunable
and
smart
luminescent
materials
aqueous
media
solid
state
with
high
emitting
efficiency
under
rigid
pumpkin-shaped
structure-derived
macrocyclic-confinement
effect
recent
years.
This
review
aims
give
systematically
up-to-date
overview
Q[n]-based
supramolecular
emissions
from
confined
spaces
triggered
host–guest
complexes,
including
assembly
fashions
mechanisms
macrocycle-based
well
their
applications.
Finally,
challenges
outlook
are
provided.
Since
this
class
emissions,
which
essentially
derived
cavity-dependent
confinement
resulting
fashions,
emerged
only
few
years
ago,
we
hope
will
provide
valuable
information
for
further
development
light-emitting
other
related
research
fields.
In
vivo
fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
has
been
considered
as
a
promising
technique
for
visualizing
mammals.
However,
definition
of
NIR-II
region
and
mechanism
accounting
excellent
performance
still
need
to
be
perfected.
Herein,
we
simulate
photon
propagation
NIR
(to
2340
nm),
confirm
positive
contribution
moderate
light
absorption
by
water
intravital
perfect
900-1880
nm,
where
1400-1500
1700-1880
nm
are
defined
NIR-IIx
NIR-IIc
regions,
respectively.
Moreover,
2080-2340
is
newly
proposed
third
(NIR-III)
window,
which
believed
provide
best
quality.
The
wide-field
microscopy
brain
performed
around
region,
with
optical
sectioning
strength
largest
depth
date.
We
also
propose
1400
long-pass
detection
off-peak
whose
exceeds
that
NIR-IIb
imaging,
using
bright
fluorophores
short
emission
wavelength.
Small,
Journal Year:
2021,
Volume and Issue:
17(6)
Published: Jan. 15, 2021
Photoacoustic
(PA)
imaging
and
photothermal
therapy
(PTT)
have
attracted
extensive
attention
in
disease
diagnosis
treatment.
Although
many
exogenous
contrast
agents
been
developed
for
PA
PTT,
the
design
guidelines
to
amplify
their
performances
remain
challenging
are
highly
demanded.
Semiconducting
polymer
nanoparticles
(SPNs)
composed
of
polymers
with
π-electron
delocalized
backbones
can
be
designed
PTT
performance,
because
clear
structure-property
relation
versatility
modifying
molecular
structures
tune
photophysical
properties.
This
review
summarizes
recent
advances
photoacoustic
applications
semiconducting
a
focus
on
signal
amplification
second
near-infrared
(NIR-II,
1000-1700
nm)
construction.
The
strategies
such
as
screening,
fluorescence
quenching,
accelerated
heat
dissipation,
size-dependent
dissipation
first
discussed
brightness
SPNs
vivo
PA.
approaches
shifting
absorption
NIR-II
then
introduced
so
improve
tissue
penetration
depth
therapy.
At
last,
current
challenges
perspectives
field
discussed.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(49)
Published: Nov. 4, 2020
Abstract
One
of
the
major
pursuits
biomedical
science
is
to
develop
advanced
strategies
for
theranostics,
which
expected
be
an
effective
approach
achieving
transition
from
conventional
medicine
precision
medicine.
Supramolecular
assembly
can
serve
as
a
powerful
tool
in
development
nanotheranostics
with
accurate
imaging
tumors
and
real‐time
monitoring
therapeutic
process
upon
incorporation
aggregation‐induced
emission
(AIE)
ability.
AIE
luminogens
(AIEgens)
will
not
only
enable
fluorescence
but
also
aid
improving
efficacy
therapies.
Furthermore,
fluorescent
signals
performance
these
nanomaterials
manipulated
precisely
owing
reversible
stimuli‐responsive
characteristics
supramolecular
systems.
Inspired
by
rapid
advances
this
field,
recent
research
conducted
on
effect
based
summarized.
Here,
three
representative
are
presented
follows:
a)
self‐assembly
AIEgens,
b)
loading
AIEgens
within
nanocarriers
assembly,
c)
macrocycle‐guided
via
host–guest
interactions.
Meanwhile,
diverse
applications
such
diagnostics
therapeutics
have
been
discussed
detail.
Finally,
challenges
field
listed
review.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(8), P. 3967 - 3973
Published: Sept. 24, 2020
Abstract
Organic
dyes
emitting
in
the
second
near‐infrared
(NIR‐II,
900–1700
nm)
window,
with
high
molar
extinction
coefficients
(MEC)
and
quantum
yields
(QY)
aqueous,
are
essential
for
vivo
bioimaging
biosensing.
In
this
work,
we
developed
a
dibodipy‐based
aggregation‐induced
emission
(AIE)
fluorescent
probe,
THPP
,
to
meet
aim.
exhibits
MEC
has
intensified
absorption
J‐aggregated
state,
which
significantly
enhance
fluorescence
intensity
(≈55
folds)
extend
maximal
absorption/emission
wavelengths
970/1010
nm
NIR‐II
region.
Based
on
bright
imaging
frame
rate
(34
frames
per
second)
at
deep
“valid
penetration
depth”
up
6
mm
can
be
achieved.
This
enabled
simultaneous
dynamic
of
vasculatures
tissues.
Besides,
succeeded
monitoring
respiratory
acute‐lung‐injury
mice
tracing
collateral
circulation
process
rate.
