Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

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Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

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Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 5136 - 5174

Published: Jan. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Language: Английский

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Emerging Strategies in Enhancing Singlet Oxygen Generation of Nano-Photosensitizers Toward Advanced Phototherapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 5, 2022

Abstract The great promise of photodynamic therapy (PDT) has thrusted the rapid progress developing highly effective photosensitizers (PS) in killing cancerous cells and bacteria. To mitigate intrinsic limitations classical molecular photosensitizers, researchers have been looking into designing new generation nanomaterial-based (nano-photosensitizers) with better photostability higher singlet oxygen (SOG) efficiency, ways enhancing performance existing photosensitizers. In this paper, we review recent development nano-photosensitizers nanoplasmonic strategies to enhance SOG efficiency for PDT performance. Firstly, explain mechanism reactive species by followed a brief discussion on commercially available their PDT. We then introduce three types that can effectively produce molecules under visible light illumination, i.e., aggregation-induced emission nanodots, metal nanoclusters (< 2 nm), carbon dots. Different design approaches synthesize these were also discussed. further rate nano-photosensitizers, plasmonic using different nanoparticles both colloidal planar metal-PS systems are reviewed. key parameters determine metal-enhanced (ME-SOG) underlined enhancement Lastly, highlight future prospects nanoengineering strategies, discuss how nanobiotechnology theoretical simulation could accelerate ME-SOG image-guided therapy.

Language: Английский

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Cationization to boost both type I and type II ROS generation for photodynamic therapy

Biomaterials, Journal Year: 2021, Volume and Issue: 280, P. 121255 - 121255

Published: Nov. 17, 2021

Language: Английский

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Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 1346 - 1357

Published: Dec. 27, 2021

Water treatment is crucial to improve the water quality and reduce diarrheal chronological diseases caused by excessive discharge of organic dyes other waste. The development expansion efficient catalysts for degradation sterilization has attracted widespread attention. Herein, we report an example a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) its sono-/photocatalytic bactericidal activity. dislocated layers effectively avoid close π-π stacking provide porous space oxygen/water/dye contact. introduction Zn ions increases spin orbital coupling through heavy atom effect promotes intersystem crossing process singlet oxygen generation. effective ligand-to-metal charge transfer open catalytic sites also facilitate splitting hydroxyl radical These features together promote reactive species (ROS) generation 2DZnTcpp under light illumination or ultrasound sonication. It worth noting that with high specific surface area porosity shows dye Moreover, could largely inactivate Escherichia coli irradiation (the power 1 sun) sonication 30 min efficiencies over 99.99999%. This work provides approach design synthesis MOF-based sono-/photocatalysts used in purification textile wastewater committed establishment more efficient, fast, environmentally friendly system.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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