Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(4), P. 1464 - 1534
Published: Feb. 5, 2024
Haptic
human-machine
interfaces
(HHMIs)
combine
tactile
sensation
and
haptic
feedback
to
allow
humans
interact
closely
with
machines
robots,
providing
immersive
experiences
convenient
lifestyles.
Significant
progress
has
been
made
in
developing
wearable
sensors
that
accurately
detect
physical
electrophysiological
stimuli
improved
softness,
functionality,
reliability,
selectivity.
In
addition,
soft
actuating
systems
have
developed
provide
high-quality
by
precisely
controlling
force,
displacement,
frequency,
spatial
resolution.
this
Review,
we
discuss
the
latest
technological
advances
of
actuators
for
demonstration
HHMIs.
We
particularly
focus
on
highlighting
material
structural
approaches
enable
desired
sensing
properties
necessary
effective
Furthermore,
promising
practical
applications
current
HHMI
technology
various
areas
such
as
metaverse,
robotics,
user-interactive
devices
are
discussed
detail.
Finally,
Review
further
concludes
discussing
outlook
next-generation
technology.
Materials Today,
Journal Year:
2023,
Volume and Issue:
63, P. 239 - 287
Published: Jan. 12, 2023
Dissolving
microneedles
(dMNs)
are
promising
versatile
drug
delivery
systems
for
the
transdermal
of
numerous
drugs,
enabling
their
use
in
a
wide
range
biomedical
and
pharmaceutical
applications.
Being
made
water-soluble
polymers,
dMNs
own
several
advantages,
including
fast
dissolution
short
application
time
which
enhance
patients'
compliance
minimize
damage
to
skin
tissue.
Moreover,
they
possess
no
biohazard
risk
as
leave
sharp
waste
behind.
For
these
reasons,
research
on
has
increased
dramatically
recent
years.
The
formulation
successful
requires
well-defined
pre-set
design,
considering
goal
payloads
that
will
be
used.
Every
aspect
patch
needles
geometry,
polymer
composition,
method
formation
payloads,
direct
effect
mechanical
properties
MNs,
affecting
administration
efficacy.
Thus,
there
is
need
understand
how
each
factor
affects
final
optimize
MN.
Taking
this
into
consideration,
review
serves
guide
dMN
formulation,
discussing
different
setbacks
step
possible
strategies
overcome
them,
improving
administration,
enhancing
loading
various
molecules
controlled
release.
Small,
Journal Year:
2023,
Volume and Issue:
19(14)
Published: Jan. 3, 2023
Conductive
polymeric
microneedle
(MN)
arrays
as
biointerface
materials
show
promise
for
the
minimally
invasive
monitoring
of
analytes
in
biodevices
and
wearables.
There
is
increasing
interest
microneedles
electrodes
biosensing,
but
efforts
have
been
limited
to
metallic
substrates,
which
lack
biological
stability
are
associated
with
high
manufacturing
costs
laborious
fabrication
methods,
create
translational
barriers.
In
this
work,
additive
manufacturing,
provides
user
design
flexibility
upscale
employed
fabricate
acrylic-based
devices.
These
devices
used
platforms
produce
intrinsically-conductive,
polymer-based
surfaces
based
on
polypyrrole
(PPy)
poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)
(PEDOT:PSS).
entirely
solid
act
dry
conductive
while
omitting
requirement
a
seed
layer.
Two
distinct
coating
methods
3D-printed
microneedles,
situ
polymerization
drop
casting,
enable
functionality.
The
penetrate
ex
vivo
porcine
skin
grafts
without
compromising
conductivity
or
morphology
demonstrate
durability
over
multiple
penetration
cycles.
non-cytotoxic
nature
evaluated
using
human
fibroblast
cells.
proposed
strategy
offers
compelling
approach
that
can
be
further
exploited
biosensing.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
201, P. 115055 - 115055
Published: Aug. 17, 2023
The
minimally-invasive
and
painless
nature
of
microneedle
(MN)
application
has
enabled
the
technology
to
obviate
many
issues
with
injectable
drug
delivery.
MNs
not
only
administer
therapeutics
directly
into
dermal
ocular
space,
but
they
can
also
control
release
profile
active
compound
over
a
desired
period.
To
enable
prolonged
delivery
payloads,
various
MN
types
have
been
proposed
evaluated,
including
dissolving
MNs,
polymeric
loaded
or
coated
nanoparticles,
fast-separable
hollow
hydrogel
MNs.
These
intricate
yet
intelligent
platforms
provide
an
attractive
approach
decrease
side
effects
administration
frequency,
thus
offer
potential
increase
patient
compliance.
In
this
review,
formulations
that
are
for
long-acting
address
clinical
needs
myriad
diseases
discussed.
We
highlight
design
aspects,
such
as
polymer
selection
geometry,
in
addition
computational
mathematical
modeling
necessary
help
streamline
develop
high
translational
value
impact.
Finally,
up-scale
manufacturing
regulatory
hurdles
along
avenues
require
further
research
bring
market
carefully
considered.
It
is
hoped
review
will
insight
formulators
clinicians
judicious
materials
tandem
refined
may
elegant
achieve
sustained
payloads
through
simple
patch.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(4), P. 1464 - 1534
Published: Feb. 5, 2024
Haptic
human-machine
interfaces
(HHMIs)
combine
tactile
sensation
and
haptic
feedback
to
allow
humans
interact
closely
with
machines
robots,
providing
immersive
experiences
convenient
lifestyles.
Significant
progress
has
been
made
in
developing
wearable
sensors
that
accurately
detect
physical
electrophysiological
stimuli
improved
softness,
functionality,
reliability,
selectivity.
In
addition,
soft
actuating
systems
have
developed
provide
high-quality
by
precisely
controlling
force,
displacement,
frequency,
spatial
resolution.
this
Review,
we
discuss
the
latest
technological
advances
of
actuators
for
demonstration
HHMIs.
We
particularly
focus
on
highlighting
material
structural
approaches
enable
desired
sensing
properties
necessary
effective
Furthermore,
promising
practical
applications
current
HHMI
technology
various
areas
such
as
metaverse,
robotics,
user-interactive
devices
are
discussed
detail.
Finally,
Review
further
concludes
discussing
outlook
next-generation
technology.
