The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 235, P. 115387 - 115387

Published: May 11, 2023

Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to fore low-cost wearable/portable smart devices. Although numerous devices that track digital biomarkers been successfully translated from bench-to-bedside, only a few follow same fate when it comes traditional biomarkers. Current practices still involve laboratory-based tests, followed by blood collection, conducted clinical setting as they require trained personnel specialized equipment. In fact, real-time, passive/active robust sensing physiological behavioural data patients can feed artificial intelligence (AI)-based models significantly improve decision-making, diagnosis treatment at point-of-procedure, circumventing conventional methods sampling, person investigation expert pathologists, who are scarce developing countries. This review brings together biomarker through portable autonomous miniaturized We first summarise technological advances each field vs current we conclude merging two worlds AI/ML technologies patient treatment. The fundamental role, limitations prospects AI realizing this potential enhancing existing facilitate development translation "point-of-care" (POC) diagnostics is finally showcased.

Language: Английский

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Wearable Microneedle Patch for Transdermal Electrochemical Monitoring of Urea in Interstitial Fluid

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(2), P. 932 - 941

Published: Jan. 22, 2024

Microneedle-based wearable electrochemical biosensors are the new frontier in personalized health monitoring and disease diagnostic devices that provide an alternative tool to traditional blood-based invasive techniques. Advancements micro- nanofabrication technologies enabled fabrication of microneedles using different biomaterials morphological features with aim overcoming existing challenges enhancing sensing performance. In this work, we report a microneedle array featuring conductive recessed microcavities for urea levels interstitial fluid skin. Microcavities small pockets on tip each can accommodate layer, protection from delamination during skin insertion or removal, position layer deep reach fluid. The patch has shown be highly sensitive selective urea, sensitivity 2.5 mV mM–1 linear range 3 18 mM making it suitable healthy individuals patients. Our ex vivo experiments have protect monitor changing This biocompatible platform provides solutions critical issue maintaining performance biosensor upon holds great potential advancing transdermal sensor technology.

Language: Английский

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Fabrication and Evaluation of Dissolving Hyaluronic Acid Microneedle Patches for Minimally Invasive Transdermal Drug Delivery by Nanoimprinting

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 89 - 89

Published: Jan. 23, 2025

Transdermal drug delivery minimizes pain and provides a controlled, stable release of drugs, but its effectiveness is limited by the skin’s natural barriers. Microneedles overcome this problem, enabling minimally invasive delivery. Microneedle patches (MNPs) with 80 µm-tall needles composed hyaluronic acid (HA) were developed evaluated for their formability, structural integrity, dissolution rate, skin penetration ability, transmission capacity. The influence molecular weight HA on these properties was also investigated. MNPs made from low-molecular-weight (30 kDa–50 kDa) demonstrated 12.5 times superior permeability in ex vivo human compared to needleless (NLPs). Furthermore, same test, had 1.7 higher than high-molecular-weight MNPs, suggesting transdermal administration. significantly influenced solubility permeability, highlighting potential as systems. Puncture tests depth 50–60 µm, indicating minimal nerve irritation dermis effective superficial dermal layer. These results present manufacturing technique incorporating model compounds highlight novel method biomedical applications soft gels.

Language: Английский

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Polymeric Microneedles: An Emerging Paradigm for Advanced Biomedical Applications

Scientia Pharmaceutica, Journal Year: 2023, Volume and Issue: 91(2), P. 27 - 27

Published: May 31, 2023

Microneedles are gaining popularity as a new paradigm in the area of transdermal drug delivery for biomedical and healthcare applications. Efficient with minimal invasion is prime advantage microneedles. The concept microneedle array provides an extensive surface efficient delivery. Various types inorganics (silicon, ceramic, metal, etc.) polymeric materials used fabrication microneedles have various advantages over other fabricated using inorganic material, such biocompatibility, biodegradation, non-toxicity. wide variety polymers can provide broad scope Multiple metallic be functionalized by polymer coatings shifting from conventional to advanced 3D 4D printing technology. multifaceted applications include delivery, vaccine biosensing, diagnostic Here, we overview current information on fabrication, selection criteria polymers, applications, regulatory perspective polymer-based polymer-coated microneedles, along patent scenario.

Language: Английский

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Ultra‐Wide Range, High Sensitivity Piezoresistive Sensor Based on Triple Periodic Minimum Surface Construction

Small, Journal Year: 2023, Volume and Issue: 19(36)

Published: May 1, 2023

Flexible piezoresistive sensors with biological structures are widely exploited for high sensitivity and detection. However, the conventional bionic structure pressure usually suffer from irreconcilable conflicts between wide detection response range. Herein, a triple periodic minimum surface (TPMS) sensor is proposed based on parametric structural design 3D printing techniques. Upon tailoring of dedicated parameters, resulting exhibit superior compression durability, sensitivity, ultra-high range, that enabling it meets needs various scenes. As model system, TPMS 40.5% porosity exhibits an (132 kPa-1 in 0-5.7 MPa), strain range (0-31.2%), repeatability durability (1000 cycles 4.41 MPa, 10000 s 1.32 low limit (1% 80 kPa). The stress/strain distributions have been identified using finite element analysis. Toward practical applications, can be applied to detect human activity health monitoring (i.e., voice recognition, finger pressure, sitting, standing, walking, falling down behaviors). synergistic effects MWCNTs MXene conductive network also ensure composite further being utilized electromagnetic interference shielding applications.

Language: Английский

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Stimuli-responsive polymer microneedles: A rising transdermal drug delivery system and Its applications in biomedical

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 88, P. 104922 - 104922

Published: Sept. 6, 2023

Language: Английский

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Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Feb. 22, 2024

Abstract Microneedles (MNs) have maintained their popularity in therapeutic and diagnostic medical applications throughout the past decade. MNs are originally designed to gently puncture stratum corneum layer of skin lately evolved into intelligent devices with functions including bodily fluid extraction, biosensing, drug administration. offer limited invasiveness, ease application, minimal discomfort. Initially manufactured solely from metals, now available polymer‐based varieties. can be used create systems that deliver drugs chemicals uniformly, collect fluids, stimulus‐sensitive. Although these advancements favorable terms biocompatibility production costs, they insufficient for use MNs. This is first comprehensive review discusses individual MN toward evolution development smart multifunctional a variety novel impactful future applications. The study examines fabrication techniques, application purposes, experimental details constructs perform multiple concurrently, sensing, drug‐molecule release, sampling, remote communication capabilities. It highly likely near future, MN‐based will useful important component standard practice different

Language: Английский

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Transdermal Sensing of Enzyme Biomarker Enabled by Chemo‐Responsive Probe‐Modified Epidermal Microneedle Patch in Human Skin Tissue

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 11, 2024

Wearable bioelectronics represents a significant breakthrough in healthcare settings, particularly (bio)sensing which offers an alternative way to track individual health for diagnostics and therapy. However, there has been no notable improvement the field of cancer, skin cancer. Here, wearable bioelectronic patch is established transdermal sensing melanoma biomarker, tyrosinase (Tyr), using microneedle array integrated with surface-bound chemo-responsive smart probe enable target-specific electrochemical detection Tyr directly from human tissue. The results presented herein demonstrate feasibility sensor direct quantification enzyme biomarkers ex vivo model. Initial performance analysis proves that designed methodology can be fast reliable diagnosis evaluation moles. innovative approach here may revolutionize landscape monitoring by offering nondisruptive means continuous surveillance timely intervention anomalies, such as inflammatory diseases or allergies extended screening multiple responses complementary simple modification device design.

Language: Английский

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Opportunities and Challenges of Microneedle Electrochemical Sensors for Interstitial Fluid Detection

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 180, P. 117891 - 117891

Published: July 31, 2024

Language: Английский

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Developing a nanomaterial-based 3D-printed platform: Application as a cancer aptasensor via detection of heat shock protein 90 (HSP90)

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 409, P. 135592 - 135592

Published: March 4, 2024

Language: Английский

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