Design of superior phototheranostic agents guided by Jablonski diagrams

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

---

Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(38), P. 7909 - 7926

Published: Jan. 1, 2021

Photothermal therapy (PTT) has been widely applied in cancer as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final effect PTT mainly depends on photothermal materials, which can be further considered to determined by conversion efficiency, biocompatibility, stability materials. this review, materials including inorganic organic organic-inorganic composite recent years have summarized terms mechanism, preparation, applications. end, perspectives obstacles their development are overviewed.

Language: Английский

---

Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

---

Structural and process controls of AIEgens for NIR-II theranostics

Chemical Science, Journal Year: 2020, Volume and Issue: 12(10), P. 3427 - 3436

Published: June 12, 2020

Aggregation-induced emission (AIE) is a cutting-edge fluorescence technology, giving highly-efficient solid-state photoluminescence. Particularly, AIE luminogens (AIEgens) with in the range of second near-infrared window (NIR-II, 1000-1700 nm) have displayed salient advantages for biomedical imaging and therapy. However, molecular design strategy underlying mechanism regulating balance between (radiative pathway) photothermal effect (non-radiative these narrow bandgap materials remain obscure. In this review, we outline latest achievements guidelines photophysical process control developing highly efficient NIR-II emitters or agents aggregation-induced attributes. We provide insights to optimize efficiency by multi-hierarchical structures from single molecules (flexibilization) aggregates (rigidification). also discuss crucial role intramolecular motions balancing functions The superiority region demonstrated fluorescence/photoacoustic blood vessels brain as well ablation tumor. Finally, summary challenges perspectives AIEgens

Language: Английский

---

Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

---

A Borondifluoride‐Complex‐Based Photothermal Agent with an 80 % Photothermal Conversion Efficiency for Photothermal Therapy in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(41), P. 22376 - 22384

Published: July 21, 2021

Abstract Small organic photothermal agents (SOPTAs) that absorb in the second near‐infrared (NIR‐II, 1000–1700 nm) window are highly desirable therapy for their good biocompatibility and deeper tissue penetration. However, design of NIR‐II absorbing SOPTAs remains a great challenge. Herein, we report molecular engineering BF 2 complex via strengthening donor‐acceptor conjugation increasing intramolecular motions is an efficient strategy to achieve with high performance. Based on this strategy, complex, BAF4, was designed synthesized. BAF4 exhibits intense absorption maximum at 1000 nm negligible fluorescence. Notably, nanoparticles conversion efficiency value 80 % under 1064 laser irradiation (0.75 W cm −2 ). In vitro vivo studies reveal potential photoacoustic imaging‐guided window.

Language: Английский

---

Near-Infrared-Absorbing B–N Lewis Pair-Functionalized Anthracenes: Electronic Structure Tuning, Conformational Isomerism, and Applications in Photothermal Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(41), P. 18908 - 18917

Published: Oct. 4, 2022

B–N-fused dianthracenylpyrazine derivatives are synthesized to generate new low gap chromophores. Photophysical and electrochemical, crystal packing, theoretical studies have been performed. Two energetically similar conformers identified by density functional theory calculations, showing that the core unit adopts a curved saddle-like shape (x-isomer) or zig-zag conformation (z-isomer). In solid state, z-isomer is prevalent according an X-ray structure of C6F5-substituted derivative (4-Pf), but variable-temperature nuclear magnetic resonance suggest dynamic behavior in solution. B–N fusion results large decrease HOMO–LUMO dramatically lowers LUMO energy compared all-carbon analogues. 4-Pf particular shows significant absorbance at greater than 700 nm while being almost transparent throughout visible region. After encapsulation biodegradable polymer DSPE-mPEG2000, nanoparticles (4-Pf-NPs) exhibit good water solubility, high photostability, excellent photothermal conversion efficiency ∼41.8%. 4-Pf-NPs evaluated both vitro vivo as therapeutic agents. These uncover Lewis pair functionalization PAHs promising strategy toward NIR-absorbing materials for applications.

Language: Английский

---

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

---

Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

---

Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 26, 2021

Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently accumulate in tumors with NIR fluorescence provide preoperative diagnosis. Most of the are excised under intraoperative navigation, whereafter, some microscopic residual completely ablated by photodynamic photothermal therapies for maximally killing cells tissues. Up 90% survival rate be achieved this synergistic image-guided surgery therapies. Importantly, nanoparticles-mediated photothermal/photodynamic plus programmed death-ligand 1 antibody significantly induce elimination enhancing effect immunotherapy. This strategy basis AIEgen improves cancer mice maximized therapeutic outcomes, holds great promise clinical treatment.

Language: Английский

---