The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.

Language: Английский

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Design of therapeutic biomaterials to control inflammation

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(7), P. 557 - 574

Published: Feb. 28, 2022

Language: Английский

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MOF-derived nanoporous carbons with diverse tunable nanoarchitectures

Nature Protocols, Journal Year: 2022, Volume and Issue: 17(12), P. 2990 - 3027

Published: Sept. 5, 2022

Language: Английский

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pHEMA: An Overview for Biomedical Applications

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(12), P. 6376 - 6376

Published: June 15, 2021

Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompatibility and cytocompatibility elicits minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties applications pHEMA bone regeneration, wound healing, cancer therapy (stimuli non-stimuli responsive systems), ophthalmic (contact lenses ocular drug delivery). As this polymer has been widely applied in applications, specific consideration devoted field. Pure does not possess antimicrobial site where device is employed may be susceptible microbial infections. Therefore, strategies such use silver nanoparticles, antibiotics, agents can utilized protect against besides delivery were covered. With continuous research advancement science technology, outlook promising will most certainly more near future. The aim review was bring together state-of-the-art on their

Language: Английский

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Rational Design of Multifunctional CuS Nanoparticle‐PEG Composite Soft Hydrogel‐Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(33)

Published: June 3, 2022

Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL‐based with enhanced bioactivity and intelligent delivery capability repair remains challenging. Herein, CuS nanoparticle‐PEG soft hydrogel‐coated 3D hard (denoted as CuS‐PEG‐PCL scaffold) are rationally designed efficient regeneration. nanoparticles cross‐linked PEG hydrogel (CuS‐PEG‐hydrogel) endows the scaffold excellent photothermal properties stable elasticity, while PCL provides mechanical performance. Upon exposure to 1064 nm near‐infrared (NIR) light irradiation, dexamethasone sodium phosphate (Dexp), stored scaffold, can be controllably released, which efficiently promotes osteogenic differentiation of mesenchymal stem cells (BMSCs). In addition, combination mild heating at 42 ± 0.5 °C further promoted BMSCs. Subsequently, this Dexp‐loaded (D‐CuS‐PEG‐PCL NIR treatment tibial defect rats presented highest regeneration capacity. These findings demonstrate that CuS‐PEG‐hydrogel effectively modify printed scaffold. Therefore, multifunctional a soft‐hard hybrid structure has potential become an advanced drug vehicle large defects.

Language: Английский

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Bone/cartilage targeted hydrogel: Strategies and applications

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 156 - 169

Published: Nov. 11, 2022

The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.

Language: Английский

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Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(7)

Published: Nov. 5, 2021

Abstract The goal of regenerative wound healing dressings is to restore tissue function back normal physiological activity and accelerate skin regeneration at sites. optimal strategy achieve this purpose requires a balance between material functionality, degradation, safety, regrowth. Herein, for the first time, an ultrasonic‐triggered irreversible tending equilibrium self‐assembly ionic cross‐linking codriven proposed producing multifunctional cinnamaldehyde‐tannic acid‐zinc acetate nanospheres (CA‐TA‐ZA NSs), realizing fusion hydrophilic hydrophobic drug‐food small molecules. Moreover, novel “all‐in‐one” chitosan (CS)‐based hydrogel functionalized by introducing molecules self‐assembled CA‐TA‐ZA NSs 3D network structures CS designed, integrating excellent antibacterial, antioxidant, anti‐inflammatory reducing oxidative stress damage abilities. Additionally, CS‐based can realize rapid in situ gelation sites completely cover irregular wounds. All these superiorities enable clean microenvironment, induce remodeling, promote blood vessel repair hair follicle regeneration, immune system activity, healing. Therefore, study offers new perspective design advanced functional materials with great application potential biomedical field.

Language: Английский

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Silk fibroin-based biomaterials for cartilage/osteochondral repair

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 5103 - 5124

Published: Jan. 1, 2022

Osteoarthritis (OA) is a common joint disease with high disability rate.In addition, OA not only causes great physiological and psychological harm to patients, but also puts pressure on the social healthcare system.Pathologically, disintegration of cartilage lesions subchondral bone are related OA.Currently, tissue engineering, which expected overcome defects existing treatment methods, had lot research in field cartilage/osteochondral repair.Silk fibroin (SF), as natural macromolecular material good biocompatibility, unique mechanical properties, excellent processability degradability, holds potential engineering.Nowadays, SF been prepared into various materials adapt demands repair.SF-based biomaterials can be functionally modified enhance repair performance further.In this review, preparation types, structures, functional modifications SF-based used for summarized discussed.We hope that review will provide reference design development field.

Language: Английский

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Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Advanced Science, Journal Year: 2021, Volume and Issue: 9(2)

Published: Nov. 19, 2021

Cancer is one of the top life-threatening dangers to human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well diagnostics. A new system within bioactive glass family, mesoporous (MBGs), has evolved into a multifunctional platform, thanks MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, volume. Although yet meet potential in tumor treatment imaging practice, recently research shed light on distinguished capabilities promising theranostic systems cancer therapy. This review presents progress field MBG diagnosis therapy, including synthesis MBGs, mechanistic overview application drug monitoring, therapy ( particularly, targeted delivery stimuli-responsive nanoplatforms), immunological profile MBG-based nanodevices reference development novel therapeutics.

Language: Английский

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Biomaterial-assisted biotherapy: A brief review of biomaterials used in drug delivery, vaccine development, gene therapy, and stem cell therapy

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 29 - 48

Published: Jan. 19, 2022

Biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to wide range of treatments applications, as demonstrated preclinical and clinical studies. However, the broad applications biotherapy have been limited by critical challenges, including lack safe efficient delivery systems serious side effects. Due unique potentials biomaterials, such good biocompatibility bioactive properties, biomaterial-assisted be an attractive strategy. The biomaterial-based possess sufficient packaging capacity versatile functions, enabling sustained localized release drugs at target sites. Furthermore, biomaterials can provide niche specific extracellular conditions for proliferation, differentiation, attachment, migration stem cells, leading tissue regeneration. In this review, state-of-the-art studies on biotherapy, drug delivery, vaccine development, gene therapy, cell summarized. challenges outlook biotherapies also discussed.

Language: Английский

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