Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: May 1, 2024
Abstract
Chirality
is
a
fundamental
property
in
nature,
which
essential
for
the
existence
and
survival
of
living
organisms.
Smart
responsive
chiroptical
materials
have
garnered
increasing
attention
due
to
their
unique
structural
characteristics
potential
applications.
Among
these,
azobenzene
(Azo),
as
typical
photoresponsive
chromophore,
plays
crucial
role
constructing
controlling
chiral
structures.
The
cis
‐
trans
isomerization,
liquid
crystallinity,
other
physicochemical
properties
allow
wide
range
tunability
stimuli‐responsive
materials.
Herein,
we
review
research
studies
field
chiral/achiral
Azo
building
blocks
multilevel
generation
well
switching,
summarize
recent
advances
on
applications
structures
from
micro
macro
levels.
Finally,
aim
provide
an
overview
challenges
new
opportunities
development
novel
smart
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 20875 - 20924
Published: Oct. 23, 2023
Cancer
with
a
complex
pathological
process
is
major
disease
to
human
welfare.
Due
the
imbalance
between
oxygen
(O2)
supply
and
consumption,
hypoxia
natural
characteristic
of
most
solid
tumors
an
important
obstacle
for
cancer
therapy,
which
closely
related
tumor
proliferation,
metastasis,
invasion.
Various
strategies
exploit
feature
have
been
developed
in
past
decade,
can
be
used
alleviate
hypoxia,
or
utilize
targeted
delivery
diagnostic
imaging.
The
include
delivering
O2,
situ
O2
generation,
reprogramming
vascular
system,
decreasing
inhibiting
HIF-1
pathways.
On
other
side,
also
utilized
hypoxia-responsive
chemical
construction
hypoxia-active
prodrug-based
strategies.
Taking
advantage
region,
number
methods
applied
identify
keep
track
changes
hypoxia.
Herein,
we
thoroughly
review
recent
progress
nanomedicine
both
conquering
utilizing
combat
put
forward
prospect
emerging
nanomaterials
future
clinical
transformation,
hopes
provide
perspectives
design.
Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
Accounts of Materials Research,
Journal Year:
2023,
Volume and Issue:
4(11), P. 925 - 938
Published: Oct. 9, 2023
ConspectusA
host–guest
drug
delivery
system
(HGDDS)
refers
to
a
complex
of
an
artificial
receptor
and
therapeutic
agent
which
can
dissociate
at
the
lesion
site
release
loaded
cargo.
Macrocyclic
receptors
are
promising
carriers
because
their
superior
properties,
including
ease
preparation,
precise
molecular
weight,
well-defined
structure,
excellent
chemical
stability.
The
loading
process
is
mild,
simple,
repeatable.
formulations
quantitatively
load
exact
cavity-loading
pattern
quantifiable
binding
constant.
Host–guest
typically
modular,
may
be
appealing
in
context
personalized
medicine
macrocyclic
act
as
platform
diverse
drugs.
These
lead
good
batch
reproductivity
application
prospects
both
scientific
research
industry.
However,
order
make
HGDDS
more
suitable
for
practical
application,
several
demands
such
high
affinity,
universal
multiple
drugs,
targeting,
stimuli-responsiveness
still
need
considered.The
hypoxia
linked
diseases
biological
processes,
cancer,
acute
chronic
diseases,
pathogenic
microbe
infection,
other
stress
responses.
As
part
our
ongoing
on
supramolecular
biomaterials
based
macrocycles
by
taking
advantage
recognition
assembly
we
have
developed
hypoxia-responsive
azocalixarenes.
azocalixarenes
possess
deepened
cavity,
resulting
affinities
encapsulation
efficiencies
toward
agents.
azo
group
one
most
frequently
employed
moieties
it
reduced
under
hypoxic
microenvironments.
This
property
confers
with
hypoxia-triggered
due
remarkable
decrease
following
reduction.
fast
kinetics
further
facilitates
efficient
accumulation
drugs
site.
azocalixarene-based
HGDDSs
been
applied
preclinical
studies
diagnosis
treatment
tumor,
bacterial
kidney
injury,
rheumatoid
arthritis.In
this
Account,
outline
recent
efforts
designing
formulating
We
first
provide
brief
introduction
HGDDSs,
features,
quantitative
ratiometric
models.
Then
design
principles
synthesis
methods,
strong
loading,
hypoxia-response
described.
applications
treating
different
followed.
Finally,
despite
rapid
development
there
problems
that
solved
scientifically
terms
clinical
translation.
Therefore,
propose
perspectives
conducted
HGDDSs.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: May 1, 2024
Abstract
Chirality
is
a
fundamental
property
in
nature,
which
essential
for
the
existence
and
survival
of
living
organisms.
Smart
responsive
chiroptical
materials
have
garnered
increasing
attention
due
to
their
unique
structural
characteristics
potential
applications.
Among
these,
azobenzene
(Azo),
as
typical
photoresponsive
chromophore,
plays
crucial
role
constructing
controlling
chiral
structures.
The
cis
‐
trans
isomerization,
liquid
crystallinity,
other
physicochemical
properties
allow
wide
range
tunability
stimuli‐responsive
materials.
Herein,
we
review
research
studies
field
chiral/achiral
Azo
building
blocks
multilevel
generation
well
switching,
summarize
recent
advances
on
applications
structures
from
micro
macro
levels.
Finally,
aim
provide
an
overview
challenges
new
opportunities
development
novel
smart
