Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering

Exploration, Journal Year: 2022, Volume and Issue: 2(1)

Published: Jan. 28, 2022

Electrospinning (e-spin) technique has emerged as a versatile and feasible pathway for constructing diverse polymeric fabric structures, which show potential applications in many biological biomedical fields. Owing to the advantages of adjustable mechanics, designable surface multi-functionalization, biomimetic capability natural tissue, remarkable progress been made flexible bioelectronics tissue engineering sensing therapeutic purposes. In this perspective, we review recent works on design hierarchically structured e-spin fibers, well as, fabrication strategies from one-dimensional individual fiber (1D) three-dimensional (3D) arrangements adaptive specific applications. Then, focus most cutting-edge their engineering. Finally, propose future challenges perspectives promoting electrospun fiber-based products toward industrialized, intelligent, multifunctional, safe

Language: Английский

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Magnetoelectric effect: principles and applications in biology and medicine– a review

Materials Today Bio, Journal Year: 2021, Volume and Issue: 12, P. 100149 - 100149

Published: Sept. 1, 2021

Magnetoelectric (ME) effect experimentally discovered about 60 years ago remains one of the promising research fields with main applications in microelectronics and sensors. However, its to biology medicine are still their infancy. For diagnosis treatment diseases at intracellular level, it is necessary develop a maximally non-invasive way local stimulation individual neurons, navigation, distribution biomolecules damaged cells relatively high efficiency adequate spatial temporal resolution. Recently developed ME materials (composites), which combine elastically coupled piezoelectric (PE) magnetostrictive (MS) phases, have been shown yield very strong effects even room temperature. This makes them toolbox for solving many problems modern medicine. The materials, processing technologies, as well most prospective biomedical will be overviewed, trends using future therapies, wireless power transfer, optogenetics considered.

Language: Английский

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Electric‐Field‐Driven Printed 3D Highly Ordered Microstructure with Cell Feature Size Promotes the Maturation of Engineered Cardiac Tissues

Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)

Published: Feb. 13, 2023

Engineered cardiac tissues (ECTs) derived from human induced pluripotent stem cells (hiPSCs) are viable alternatives for repair, patient-specific disease modeling, and drug discovery. However, the immature state of ECTs limits their clinical utility. The microenvironment fabricated using 3D scaffolds can affect cell fate, is crucial maturation ECTs. Herein, authors demonstrate an electric-field-driven (EFD) printed highly ordered microstructure with feature size to promote simulation experimental results that EFD jet microscale printing overcomes repulsion without any prior requirements both conductive insulating substrates. Furthermore, microstructures a fiber diameter 10-20 µm spacing 60-80 have been by maintaining vertical jet, achieving largest ratio diameter/spacing 0.29. hiPSCs-derived cardiomyocytes formed sarcomere growth along developed synchronous functional inside 3D-printed scaffold matured calcium handling compared 2D coverslip. Therefore, process facilitates fabrication providing suitable ECTs, thereby showing great potential tissue engineering.

Language: Английский

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Advanced surface engineering of titanium materials for biomedical applications: From static modification to dynamic responsive regulation

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 15 - 57

Published: March 27, 2023

Titanium (Ti) and its alloys have been widely used as orthopedic implants, because of their favorable mechanical properties, corrosion resistance biocompatibility. Despite significant success in various clinical applications, the probability failure, degradation revision is undesirably high, especially for patients with low bone density, insufficient quantity or osteoporosis, which renders studies on surface modification Ti still active to further improve results. It discerned that physicochemical properties directly influence even control dynamic interaction subsequently determines rejection implants. Therefore, it crucial endow bulk materials specific high bioactivity can be performed by realize osseointegration. This article first reviews characteristics conventional techniques involving mechanical, physical chemical treatments based formation mechanism modified coatings. Such methods are able but surfaces static state cannot respond biological cascades from living cells tissues. Hence, beyond traditional design, responsive avenues then emerging. The stimuli sources functionalization originate environmental triggers physiological triggers. In short, this review surveys recent developments engineering materials, a emphasis advances functionality, provides perspectives improving biocompatibility

Language: Английский

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Recent Progress on Structure Manipulation of Poly(vinylidene fluoride)‐Based Ferroelectric Polymers for Enhanced Piezoelectricity and Applications

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(38)

Published: May 28, 2023

Abstract Poly(vinylidene fluoride) (PVDF)‐based polymers demonstrate great potential for applications in flexible and wearable electronics but show low piezoelectric coefficients (e.g., − d 33 < 30 pC N −1 ). The effective improvement the piezoelectricity of PVDF is achieved by manipulating its semicrystalline structures. However, there still a debate about which component primary contributor to piezoelectricity. Therefore, current methods improve can be classified into modulations amorphous phase, crystalline region, crystalline–amorphous interface. Here, basic principles measurements soft are first discussed. Then, three different categories structural reviewed. In each category, physical understanding strategies performance particular, crucial role oriented fraction at interface determining emphasized. At last, future development high outlooked.

Language: Английский

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Piezoelectric stimulation from electrospun composite nanofibers for rapid peripheral nerve regeneration

Nano Energy, Journal Year: 2022, Volume and Issue: 98, P. 107322 - 107322

Published: May 3, 2022

Language: Английский

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3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

International Journal of Extreme Manufacturing, Journal Year: 2023, Volume and Issue: 5(3), P. 032007 - 032007

Published: May 24, 2023

Abstract Piezoelectricity in native bones has been well recognized as the key factor bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention repairing damaged by mimicking tissue’s electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations creating personalized scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on principle of layer-by-layer forming and stacking discrete demonstrated outstanding advantages fabricating scaffolds a more complex-shaped structure. Notably, 4D functionality-shifting can provide time-dependent programmable tissue EM response to external stimuli for In this review, we first summarize physicochemical properties commonly used (including polymers, ceramics, composites) representative biological findings Then, discuss latest research advances 3D terms feedstock selection, process, induction strategies, potential Besides, some related challenges such scalability, resolution, stress-to-polarization conversion efficiency, non-invasive ability after implantation put forward. Finally, highlight shape/property/functionality-shifting smart engineering (BTE). Taken together, review emphasizes appealing utility 3D/4D printed piezoelectric next-generation BTE implants.

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Jan. 19, 2023

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests mechanical derived from the cellular microenvironment are essential controllers of cell behaviors. Conventional culture biomaterials, with static properties such as chemistry, topography, stiffness, have offered fundamental understanding various vital biochemical biophysical processes, adhesion, spreading, migration, growth, differentiation. At present, novel biomaterials can spatiotemporally impart cues manipulate fate emerging. adaptive traits new materials endow them ability adapt requirements enhance functions. In this review, an introductory overview key players mechanobiology provided. A perspective on state-of-the-art manipulation techniques in designing ECM-mimicking taken. particular, different regulating mechanosensing functions compared. This review benefit development engineering biomechanical systems expected.

Language: Английский

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A multi-stable ultra-low frequency energy harvester using a nonlinear pendulum and piezoelectric transduction for self-powered sensing

Mechanical Systems and Signal Processing, Journal Year: 2023, Volume and Issue: 189, P. 110034 - 110034

Published: Jan. 9, 2023

This paper presents the design, theoretical modelling and experimental validation of a quad-stable energy harvester for harnessing ultra-low frequency random motions using nonlinear pendulum piezoelectric transduction. The multi-stable is created by magnetic forces between magnets on tip magnet cantilever beam. Two attractive one repulsive in combination with gravitational force create multiple stable positions pendulum. dynamics allow to effectively convert low-frequency kinetic from host, e.g. human motion or wind turbine tower oscillation into oscillation, enabling effective plucking beam enhanced output power. A model, including interaction, conversion dynamics, established describe electromechanical whole harvester. prototype fabricated tested linear shaker at frequencies (1–3 Hz) showcase capability validate results. Around 8 μW Root-Mean-Square power was obtained 2.5 Hz 0.8 g excitation. Using experimentally validated parametric study carried out examine influence different structural operating parameters, such as mass length, coupling strength, excitation amplitude, range operation can be adjusted changing above-mentioned parameters. self-powered sensing then illustrated integrating an off-the-shelf management circuit 22 μF storage capacitor. capacitor charged 2.8 V 4 90 s, showing its implementing battery-free wireless Internet Things (IoT) applications.

Language: Английский

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