Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Jan. 19, 2023

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests mechanical derived from the cellular microenvironment are essential controllers of cell behaviors. Conventional culture biomaterials, with static properties such as chemistry, topography, stiffness, have offered fundamental understanding various vital biochemical biophysical processes, adhesion, spreading, migration, growth, differentiation. At present, novel biomaterials can spatiotemporally impart cues manipulate fate emerging. adaptive traits new materials endow them ability adapt requirements enhance functions. In this review, an introductory overview key players mechanobiology provided. A perspective on state-of-the-art manipulation techniques in designing ECM-mimicking taken. particular, different regulating mechanosensing functions compared. This review benefit development engineering biomechanical systems expected.

Language: Английский

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Hybrid Organic–Inorganic Materials Prepared by Sol–Gel and Sol–Gel-Coating Method for Biomedical Use: Study and Synthetic Review of Synthesis and Properties

Coatings, Journal Year: 2024, Volume and Issue: 14(4), P. 425 - 425

Published: April 1, 2024

The need to improve the expectancy and quality of life subjects affected by disabling pathologies that require replacement or regeneration tissues parts body has fueled development innovative, better-performing materials are capable integrating into being tolerated tissues. Materials with these characteristics, i.e., bio-functionality, bio-safety, biocompatibility, defined as biomaterials. One many methods for producing such is sol–gel technique. This process mainly used preparation ceramic oxides at low temperatures, through hydrolysis polycondensation reactions organometallic compounds within a hydroalcoholic solution. study based on specific type biomaterial: organic–inorganic hybrids. aim this provide an overview advantages disadvantages technique, well describe chemical biological characterization, uses, future prospects In particular, use plant drugs organic components hybrid material innovation manuscript. properties extracts numerous, reason, they deserve great attention from scientific community.

Language: Английский

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Hydrogels: Classifications, fundamental properties, applications, and scopes in recent advances in tissue engineering and regenerative medicine – A comprehensive review

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105968 - 105968

Published: Aug. 17, 2024

Hydrogels are three-dimensional structures that serve as substitutes for the extracellular matrix (ECM) and possess outstanding physicochemical biochemical characteristics. They gaining importance in regenerative medicine because of their similarity to natural terms moisture content wound tissue healing permeability. Tissue engineering advancements have resulted development flexible hydrogels mimic dynamic characteristics ECM. Several approaches been applied produce from biopolymers with enhanced functional structural different applications (TERM). This review provides a comprehensive overview hydrogel healing, engineering, drug delivery systems. We outline types based on physical chemical crosslinking, fundamental properties, TERM. article provided recent literature within five years. Recent developments biopolymer-based state-of-the-art discussed, emphasizing significant challenges future perspectives.

Language: Английский

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Injectable self-crosslinking hyaluronic acid/silk fibroin blend hydrogel based on disulfide bond

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123374 - 123374

Published: Feb. 11, 2025

Language: Английский

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Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical and mechanical nature of native tissues are needed for advanced models development disease. Biomedical research has heavily relied on use animal-derived biomaterials, which is now impeding their translational potential convoluting biological insights gleaned from in vitro tissue models. Natural hydrogels have long served as a convenient effective cell culture tool, but advances materials chemistry fabrication techniques present promising new avenues creating xenogenic-free ECM substitutes appropriate organotypic microphysiological systems. However, significant challenges remain synthetic matrices approximate structural sophistication, complexity, dynamic functionality tissues. This review summarizes key properties ECM, discusses recent approaches used to systematically decouple tune these matrices. The importance mechanics, such viscoelasticity plasticity, also discussed, particularly within context organoid engineered Emerging design strategies mimic reviewed, multi-network hydrogels, supramolecular chemistry, assembled monomers.

Language: Английский

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Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1186 - 1186

Published: Sept. 20, 2024

Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs, such as heparan sulfate (HS) chondroitin (CS), interact various cell surface receptors, including integrins receptor tyrosine kinases, to modulate responses mechanical stimuli. PGs, comprising a core protein covalently attached GAG chains, serve dynamic regulators tissue mechanics behavior, thereby playing crucial role maintaining homeostasis. Dysregulation GAG/PG-mediated pathways is implicated numerous pathological conditions, cancer inflammation. Understanding intricate mechanisms by which GAGs PGs forces holds promise for developing novel therapeutic strategies targeting mechanotransduction disease. This comprehensive overview underscores importance key mediators homeostasis their potential targets mitigating mechano-driven pathologies, focusing on

Language: Английский

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Dynamic Col-HZ Hydrogel with Efficient Delivery of Bioactivator Promotes ECM Deposition and Cartilage Formation

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101623 - 101623

Published: Feb. 28, 2025

Efforts in cartilage tissue engineering to repair injuries have seen limited success, primarily due the inability of scaffold materials establish a microenvironment conducive extracellular matrix (ECM) deposition by chondrocytes. Hydrogels, which mimic human tissue, are commonly employed as materials; however, their constrained network structure and low bioactivity impede chondrocyte ECM deposition, complicating repair. In this study, we developed dynamic Col-HZ hydrogels featuring adaptive networks forming hydrazone (HZ) bonds between bioactive natural collagen synthetic polyethylene glycol (PEG). contrast static that rely on covalent bonds, facilitate migration deposition. Additionally, aldehyde groups hydrogel can engage Schiff base bonding with amine groups. Leveraging non-covalent interaction, incorporated bioactivator TD-198946, known enhance synthesis, into hydrogel. This significantly boosted reduced inflammation. Transcriptomic sequencing bioinformatics analyses indicate both binding TD-198946 promote through modulation Wnt/β-catenin signaling pathway. Consequently, hydrogel, combination creates an improved supports facilitates formation.

Language: Английский

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Intrafibrillar Crosslinking Enables Decoupling of Mechanical Properties and Structure of a Composite Fibrous Hydrogel

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 6, 2023

The fibrous network of an extracellular matrix (ECM) possesses mechanical properties that convey critical biological functions in cell mechanotransduction. Engineered hydrogels show promise emulating key aspects ECM structure and functions. However, varying hydrogel mechanics without changing its architecture remains a challenge. A composite is developed to vary gel stiffness affecting by controlling intrafibrillar crosslinking. formed from aldehyde-modified cellulose nanocrystals gelatin methacryloyl provide the capability photocrosslinking. By degree functionalization with groups and/or photoirradiation time, hydrogel's elastic modulus changed more than order magnitude, while preserving same fiber diameter pore size. used seed primary mouse lung fibroblasts test role on fibroblast contraction activation. Increasing stronger crosslinking results enhanced activation increased force, yet at reduced speed. approach enables fabrication biomimetic decoupled structural properties, facilitating studies tissue development disease progression.

Language: Английский

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Biaxial stretching of polytetrafluoroethylene in industrial scale to fabricate medical ePTFE membrane with node-fibril microstructure

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Expanded polytetrafluoroethylene (ePTFE) is promising in biomedical fields such as covered stents and plastic surgery owing to its excellent biocompatibility mechanical properties. However, ePTFE material prepared by the traditional biaxial stretching process with thicker middle thinner sides due bowing effect, which poses a major problem industrial-scale fabrication. To solve this problem, we design an olive-shaped winding roller provide part of tape greater longitudinal amplitude than two sides, so make up for excessive retraction tendency when it transversely stretched. The as-fabricated membrane has, designed, uniform thickness node-fibril microstructure. In addition, examine effects mass ratio lubricant PTFE powder, sintering temperature on performance resultant membranes. Particularly, relation between internal microstructure properties revealed. Besides stable properties, sintered exhibits satisfactory biological We series assessments including

Language: Английский

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Cellular elasticity in cancer: a review of altered biomechanical features

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(22), P. 5299 - 5324

Published: Jan. 1, 2024

A large number of studies have shown that changes in biomechanical characteristics are an important indicator tumor transformation normal cells. Elastic deformation is one the more studied features cells, which plays role tumourigenesis and development. Altered cell elasticity often brings many indications. This manuscript reviews effects altered cellular on characteristics, including adhesion viscosity, migration, proliferation, differentiation stiffness. Also, physical factors may affect elasticity, such as temperature, height, cell-viscosity, aging, summarized. Then, cell-matrix, cytoskeleton, vitro culture medium, cell-substrate with different three-dimensional structures during tumorigenesis outlined. Importantly, we summarize current signaling pathways well tests for elastic deformation. Finally, hybrid materials: polymer-polymer, protein-protein, protein-polymer hybrids, also, nano-delivery strategies target resilience cases at least clinical phase 1 trials. Overall, behavior cancer modulated by biological, chemical, changes, turn potential to alter this be encouraging prediction future discovery therapies.

Language: Английский

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