Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy DOI
Chan Ho Kim, Kyu Eun Lee, Hyewon Ko

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1088 - 1112

Published: Jan. 29, 2024

Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.

Language: Английский

Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy DOI
Shaojun Peng,

Fengfeng Xiao,

Meiwan Chen

et al.

Advanced Science, Journal Year: 2021, Volume and Issue: 9(1)

Published: Nov. 19, 2021

Abstract The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges. With the advantages of controlled delivery modular flexibility, nanomedicine offered opportunities to strengthen antitumor immune responses sensitize tumor immunotherapy. Furthermore, tumor‐microenvironment (TME)‐responsive been demonstrated achieve specific localized amplification tissue a safe effective manner, increasing immunotherapy reducing side effects simultaneously. Here, recent TME‐responsive for is summarized, responds signals TME, such as weak acidity, reductive environment, high‐level reactive oxygen species, hypoxia, overexpressed enzymes, adenosine triphosphate. Moreover, combine nanomedicine‐based therapy immunotherapeutic strategies overcome each step cancer‐immunity cycle enhance discussed. Finally, existing challenges further perspectives this rising field with hope improved development applications are

Language: Английский

Citations

285
Stimuli-activatable nanomedicine meets cancer theranostics DOI Creative Commons
Haonan Li, Feng Yue, Qiang Luo

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

Citations

147
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy DOI Creative Commons
Jie Yang, Dihua Dai, Xi Zhang

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 13(1), P. 295 - 323

Published: Dec. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Language: Английский

Citations

140
Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing DOI

Xingjun Zhao,

Linna Chang,

Yanan Hu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(16), P. 18194 - 18208

Published: April 12, 2022

Bacterial infection has been a considerable obstacle for diabetic wound healing. A multifunctional nanoplatform used as nanozyme bacterial infected is extremely attractive. Therefore, gold nanoclusters modified zirconium-based porphyrin metal-organic frameworks (Au NCs@PCN) were constructed by an in situ growth method. Through SEM, TEM, and EDS mapping, the surface of ellipsoid-shaped particles around 190 nm was observed to be evenly interspersed with 5-8 nanoclusters. Notably, Au NCs@PCN exhibits excellent performance exciting ROS generation photothermal effects. Under near-infrared (NIR) laser irradiation, can heated 56.2 °C produce ROS, showing effective killing effect on bacteria. Antibacterial studies showed that inhibited MRSA AmprE. coli destroying membrane structure inducing protein leakage up 95.3% 90.6%, respectively. Animal experiments treated rats had reduced coverage 2.7% within 21 days. The immunoblot analysis proangiogenic proepithelial cell proliferation factors expressed significantly up-regulated. These results prove photocatalytic activity broad application prospect promoting

Language: Английский

Citations

134
Hybrid Nanomaterials for Cancer Immunotherapy DOI Creative Commons
Jianing Li,

Wanyue Lu,

Yannan Yang

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(6)

Published: Dec. 25, 2022

Abstract Nano‐immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions properties, usually organic inorganic, have engineered integrated functions enormous potential boosting immunotherapy. This review provides summary hybrid reported immunotherapy, including nanoscale metal–organic frameworks, metal–phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer–lipid, biomacromolecule‐based nanomaterials. The combination chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic photothermal photodynamic sonodynamic therapy based on is also discussed. Finally, the current challenges prospects designing their application are outlined.

Language: Английский

Citations

72
Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy DOI
Jianfeng Guo, Yifang Zou,

Leaf Huang

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 5, 2023

Immunogenic cell death (ICD, also known as immunogenic apoptosis) of malignant cells is confirmed to activate the host immune system prevent, control, and eliminate tumors. Recently, a range chemotherapeutic drugs have been repurposed ICD inducers applied for tumor immunotherapy. However, several hurdles widespread application remain, namely poor water solubility, short blood circulation, non-specific tissue distribution, severe toxicity. Recent advances in nanotechnology pharmaceutical formulation foster development nano drug delivery systems tackle aforementioned expedite safe, effective, specific delivery. This review will describe barriers chemical highlight recent nanoformulations these

Language: Английский

Citations

58
Immunoadjuvant-Functionalized Metal-Organic Frameworks：Synthesis and Applications in Tumor Immune Modulation DOI
Chen Zhao, Weihua Song,

Jianing Wang

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This review explores the synthesis, drug loading, and surface modifications of metal–organic frameworks (MOFs), highlighting their role in improving cancer immunotherapy paving way for safer more effective treatments.

Language: Английский

Citations

47
Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy DOI Creative Commons

Wenting Hu,

Binglin Ye,

Guocan Yu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 17, 2024

Abstract Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death is accompanied by checkpoint inhibitors, can induce effective immunogenic long‐term activation. Therapeutic strategies to jointly pyroptosis reverse immunosuppressive microenvironments are promising for cancer immunotherapy. In this regard, dual‐responsive supramolecular polymeric nanomedicine (NCSNPs) self‐cascade amplify the benefits immunotherapy designed. The NCSNPs formulated β‐cyclodextrin coupling nitric oxide (NO) donor, activator, NLG919, an indoleamine 2,3‐dioxygenase (IDO) inhibitor, self‐assembled through host–guest molecular recognition hydrophobic interaction obtain nanoparticles. possess excellent accumulation bioavailability attributed ingenious engineering. study not only confirms occurrence NO‐triggered first time but also reverses microenvironment sites via IDO inhibitor enhancing infiltration cytotoxic T lymphocytes, achieve remarkable inhibition proliferation. Thus, provides novel strategy

Language: Английский

Citations

18
Stepwise Size Shrinkage Cascade‐Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis DOI Creative Commons

Mengyun Liang,

Meng‐Jie Zhang,

Wei Qiu

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(26)

Published: July 22, 2022

Effective pyroptosis induction is a promising approach to potentiate cancer immunotherapy. However, the actual efficacy of present inducers can be weakened by successive biological barriers. Here, cascaded pH-activated supramolecular nanoprodrug (PDNP) with stepwise size shrinkage property developed as inducer boost antitumor immune response. PDNPs comprise multiple poly(ethylene glycol) (PEG) and doxorubicin (DOX) drug-polymer hybrid repeating blocks conjugated ultra-pH-sensitive benzoic imine (bzi) hydrazone (hyd) bonds. The PEG units endow its "stealth" ensure sufficient tumor accumulation. A sharp switch in particle detachment shielding triggered acidic extracellular pH achieve deep intratumor penetration. Following endocytosis, second-stage switching initiated more endolysosomes, disassociate into ultrasmall cargo accurate intracellular delivery. activation effectively elicit gasdermin E (GSDME)-mediated enhance immunological In combination anti-PD-1 antibody, amplify suppression extend survival mice, which suggests powerful adjuvant pave way for high-efficiency checkpoint blockade therapy.

Language: Английский

Citations

61
ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation DOI Creative Commons
Lulu Jin, Zhixin Zhu,

Liangjie Hong

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 19, P. 38 - 49

Published: April 1, 2022

Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects people's health brings huge economic burden to society. Microglia, as important innate immune components in central nervous system (CNS), are double-edged swords the battle of nerve injury, considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 phenotypes. High mobility group box 1 (HMGB1) one potent mediators that promotes microglia. 18β-glycyrrhetinic acid (GA) effective intracellular inhibitor HMGB1, but poor water solubility dose-dependent toxicity. To overcome shortcomings GA delivery improve efficacy ischemia therapy, herein, we designed reactive oxygen species (ROS) responsive polymer-drug conjugate nanoparticles (DGA) manipulate microglia by suppressing translocation nuclear HMGB1. DGA presented excellent therapeutic mice, evidenced reduction infarct volume, recovery motor function, suppressed activation enhanced activation, induction neurogenesis. Altogether, our work demonstrates a close association HMGB1 polarization, suggesting potential strategies for coping with inflammatory microglia-related diseases.

Language: Английский

Citations

58