Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4
Published: Jan. 28, 2025
KEYWORDS: Strokenanotherapynanomedicinenanoparticledrug deliverytargeted therapyinflammationoxidative stress
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 12, 2024
Abstract Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due its complicated pathophysiological features, current treatment options after ischemic attack remains unsatisfactory. Insufficient drug delivery lesions impeded by blood–brain barrier (BBB) largely limits therapeutic efficacy of most anti‐stroke agents. Herein, inspired rapid BBB penetrability 4T1 tumor cells upon their brain metastasis and natural roles platelet in targeting injured vasculatures, bio‐derived nanojacket developed fusing cell membrane with membrane, which further clothes on surface paeonol polymetformin‐loaded liposome obtain biomimetic nanoplatforms (PP@PCL) for treatment. The designed PP@PCL could remarkably alleviate ischemia‐reperfusion injury efficiently lesion, preventing neuroinflammation, scavenging excess reactive oxygen species (ROS), reprogramming microglia phenotypes, promoting angiogenesis due synergistic mechanisms anchor characteristics stroke. As result, exerts desirable PC12 neuronal rat model stroke, significantly attenuates apoptosis, reduces infarct volume, recovers neurological functions, bringing new insights into exploiting promising strategies cerebral management.
Language: Английский
Citations
33
Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)
Published: April 9, 2024
Abstract Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently lacking. Because inflammation mediated an imbalance of M1/M2 macrophages in the synovial cavities contributes to progression, regulating M1 M2 polarization can be potential therapeutic strategy. Basing on inherent immune mechanism pathological environment OA, immunoglobulin G‐conjugated bilirubin/JPH203 self‐assembled nanoparticle (IgG/BRJ) developed, its evaluated. After intra‐articular administration, IgG conjugation facilitates recognition engulfment nanoparticles macrophages. The internalized disassemble response increased oxidative stress, released bilirubin (BR) JPH203 scavenge reactive oxygen species (ROS), inhibit nuclear factor kappa‐B pathway, suppress activated mammalian target rapamycin result repolarization enhance M2/M1 ratios. Suppression IgG/BRJ promotes protection repair rat model, thereby improving outcomes. This strategy opsonization involving engulf carrier‐free BR/JPH203 therapy holds great intervention treatment.
Language: Английский
Citations
20
Translational Stroke Research, Journal Year: 2024, Volume and Issue: unknown
Published: May 14, 2024
Abstract Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration rtPA essential for restoring perfusion acute ischemic stroke, though it concurrently elevates the risk hemorrhagic transformation. High-mobility group box 1 (HMGB1) emerges as a pivotal player neuroinflammation after brain ischemia ischemia–reperfusion. Released passively necrotic cells actively secreted, including direct secretion HMGB1 into extracellular space packaging intracellular vesicles immune cells, glial platelets, endothelial represents prototypical damage-associated molecular pattern (DAMP). It intricately involved pathogenesis atherosclerosis, thromboembolism, detrimental inflammation during early phases stroke. Moreover, significantly contributes to neurovascular remodeling functional recovery later stages. Significantly, mediates transformation facilitating neuroinflammation, directly compromising integrity blood–brain barrier, enhancing MMP9 through interaction with rtPA. As systemic inflammatory factor, also implicated post-stroke depression an elevated stroke-associated pneumonia. role extends influencing polarizing various subtypes cells. This includes mediating excitotoxicity due excitatory amino acids, autophagy, release, NET formation, autocrine trophic pathways. Given multifaceted role, recognized crucial therapeutic target prognostic marker stroke In this review, we summarize structure redox properties, pathways, regulation cell activity, pathophysiological mechanisms hemorrhage HMGB1, which will pave way developing new neuroprotective drugs, reduction expansion thrombolysis time window.
Language: Английский
Citations
18
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)
Published: April 9, 2024
Spinal cord injury (SCI) often leads to a severe permanent disability. A poor inflammatory microenvironment and nerve electric signal conduction block are the main reasons for difficulty in spinal regeneration. In this study, black phosphorus (BP) glycyrrhizic acid (GA) integrated into methacrylate-modified silk fibroin (SF) construct bifunctional injectable hydrogel (SF/BP/GA) with appropriate conductivity ability inhibit inflammation promote neuronal regeneration after SCI. This work discovers that SF/BP/GA can reduce oxidative damage mediated by oxygen free radicals, polarization of macrophages toward anti-inflammatory M2 phenotype, expression factors, improve microenvironment. Moreover, it induces neural stem cell (NSC) differentiation neurosphere formation, restores at SCI site vivo, ameliorates motor function mice hemisection, revealing significant repair effect. An injectable, electroconductive, free-radical-scavenging is promising therapeutic strategy repair.
Language: Английский
Citations
17
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 21, 2025
Abstract Central nervous system (CNS) injuries, such as ischemic stroke (IS), intracerebral hemorrhage (ICH) and traumatic brain injury (TBI), are a significant global burden. The complex pathophysiology of CNS is comprised primary secondary injury. Inflammatory incited by damage-associated molecular patterns (DAMPs) which signal variety resident cells infiltrating immune cells. Extracellular cold-inducible RNA-binding protein (eCIRP) DAMP acts through multiple non-immune to promote inflammation. Despite the well-established role eCIRP in systemic sterile inflammation, its less elucidated. Recent literature suggests that pleiotropic inflammatory mediator also being evaluated clinical biomarker indicate prognosis injuries. This review provides broad overview injury, with focus on immune-mediated neuroinflammation. We then what known about mechanisms both non-CNS cells, identifying opportunities for further study. explore eCIRP’s potential prognostic marker severity outcome. Next, we provide an eCIRP-targeting therapeutics suggest strategies develop these agents ameliorate Finally, emphasize exploring novel mechanisms, aside from neuroinflammation, critical therapeutic target
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114541 - 114541
Published: March 22, 2023
High mobility group box 1 (HMGB1) is a ubiquitous and highly conserved non-histone DNA-binding protein with different biological functions according to its subcellular localization. It widely believed that HMGB1, which released into the extracellular space, plays key role in inflammatory response. In recent years, numerous studies have shown development of various neurological diseases such as epilepsy, Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS), multiple (MS), cerebrovascular traumatic brain injury (TBI) are inextricably linked inflammation. We will review mechanisms HMGB1 receptors nervous system inflammation provide basis for further new HMGB1-based therapies.
Language: Английский
Citations
24
Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)
Published: Feb. 28, 2024
Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range
Language: Английский
Citations
12
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11
Published: Feb. 2, 2024
Ischemic stroke (IS) refers to local brain tissue necrosis which is caused by impaired blood supply the carotid artery or vertebrobasilar system. As second leading cause of death in world, IS has a high incidence and brings heavy economic burden all countries regions because its disability rate. In order effectively treat IS, large number drugs have been designed developed. However, most with good therapeutic effects confirmed preclinical experiments not successfully applied clinical treatment due low accumulation efficiency areas after systematic administration. an emerging strategy for stimuli-responsive nanomedicines made great progress precisely delivering site IS. By response specific signals, change their particle size, shape, surface charge structural integrity, enables enhanced drug delivery controlled release within tissue. This breakthrough approach only enhances but also mitigates side commonly associated thrombolytic neuroprotective drugs. review aims comprehensively summarize recent Furthermore, prospect provided look forward better development this field.
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 18, 2024
Abstract Ischemic stroke is a complex, high-mortality disease with multifactorial etiology and pathogenesis. Currently, drug therapy mainly used treat ischemic in clinic, but there are still some limitations, such as limited blood-brain barrier (BBB) penetration efficiency, narrow treatment time window side effects. Recent studies have pointed out that delivery systems based on polymeric nanocarriers can effectively improve the insufficient for stroke. They provide neuronal protection by extending plasma half-life of drugs, enhancing drug’s permeability to penetrate BBB, targeting specific structures cells. In this review, we classified delivering drugs introduced their preparation methods. We also evaluated feasibility effectiveness discussed existing limitations prospects treatment. hoped review could theoretical basis future development nanomedicine Graphical
Language: Английский
Citations
10
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 20, 2024
Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment ischemic lies limited efficacy administering therapeutic agents. Leveraging unique properties nanoparticles for brain targeting crossing blood-brain barrier, researchers have engineered diverse nanoparticle-based drug delivery systems improve outcomes stroke. This review provides a concise overview pathophysiological mechanisms implicated stroke, encompassing oxidative stress, glutamate excitotoxicity, neuroinflammation, cell death, elucidate potential targets systems. Furthermore, outlines classification according these distinct physiological processes. categorization aids identifying attributes commonalities that target specific pathways thereby facilitating advancement nanomedicine development. The discusses benefits existing associated with employing offering new perspectives on designing efficacious enhance outcomes.
Language: Английский
Citations
9