Biomarker-driven molecular imaging probes in radiotherapy

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

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RhNi Bimetallenes with Lattice‐Compressed Rh Skin towards Ultrastable Acidic Nitrate Electroreduction

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 26, 2024

Harvesting recyclable ammonia (NH

Language: Английский

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Chitosan-based hydrogel dressings for diabetic wound healing via promoting M2 macrophage-polarization

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 331, P. 121873 - 121873

Published: Jan. 30, 2024

Language: Английский

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Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2194 - 2209

Published: March 2, 2024

Despite the great potential of anti-PD-L1 antibodies for immunotherapy, their low response rate due to an immunosuppressive tumor microenvironment has hampered application. To address this issue, we constructed a cell membrane-coated nanosystem (mB4S) reverse immuno-supportive one strengthening anti-tumor effect. In system, Epirubicin (EPI) as immunogenic death (ICD) inducer was coupled branched glycopolymer

Language: Английский

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Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016

Published: Dec. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Language: Английский

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Dendritic Polymer‐Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Antitumor Immune Response

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: March 12, 2024

Abstract The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote an immunogenic cell death (ICD) inducer (epirubicin, Epi) apoptotic vesicles, ultimately enhancing efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)‐based nanomedicines (poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS] (P‐DAS) poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi] (P‐Epi)) are developed for delivery DAS Epi, respectively. P‐DAS reprograms CAFs reduce collagen downregulating anabolism energy metabolism, thereby reducing deposition. regulated can enhance tumor P‐Epi strengthen its ICD effect, leading amplified antitumor immune response. In cancer‐bearing mice, this approach alleviates barrier, resulting reduced burden increased cytotoxic T lymphocyte infiltration, more encouragingly, synergizes effectively with anti‐programmed 1 (PD‐1) therapy, significantly inhibiting growth preventing lung metastasis. Furthermore, systemic toxicity barely detectable after P‐Epi. This opens new avenue treating desmoplastic tumors metabolically targeting overcome barrier.

Language: Английский

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Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 204 - 215

Published: May 31, 2024

Language: Английский

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Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 25, 2024

Abstract The growth state of tumor cells is strictly affected by the specific abnormal redox status microenvironment (TME). Moreover, reactions at biological level are also central and fundamental to essential energy metabolism in tumors. Accordingly, anti‐tumor nanodrugs targeting disruption this homeostasis have become one hot spots field research due effectiveness TME modulation efficiency mediated interference. This review discusses latest results therapy, which regulate levels oxidants or reductants through a variety therapeutic strategies, ultimately breaking original “stable” promoting cell death. With gradual deepening study on vigorous development nanomaterials, it expected that more nano drugs based regulation will be designed even applied clinically.

Language: Английский

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Rhein‐based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: April 15, 2024

Abstract The efficacy of transarterial chemoembolization (TACE) has been limited by insufficient embolization and a high incidence tumor recurrence. Herein, we identified that aberrant metabolic reprogramming immunosuppression contribute to TACE refractoriness Rhein, as potential glycolytic metabolism inhibitor immunoactivation inducer, was optimized sensitize tumors therapy. To achieve efficient embolization, developed an oil‐in‐water lipiodol embolic emulsion stabilizing the self‐assembled Rhein nanogel. assembled exhibited nanofiber network, its integration enhanced mechanical stability viscoelasticity agent. With synergistic advantages solid liquid agents, this carrier‐free Pickering exhibits sustained drug release in models unilateral renal artery rabbit ear orthotopic liver cancer, rat cancer. Compared conventional three‐way catheter mixing methods, multimodal imaging corroborates marked enhancement local retention suppression. Importantly, incorporation Rhein‐mediated immunoembolization strategy achieved while robustly activating anti‐tumor immune responses, including inducing immunogenic cell death, dendritic activation, major histocompatibility complex class I presentation CD8 + T cells for killing. Together, these findings reveal novel application nanofiber‐stabilized control signaling TACE.

Language: Английский

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Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1284 - 1293

Published: Jan. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Language: Английский

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