Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Covalent
organic
frameworks
(COFs),
known
for
their
exceptional
in
situ
encapsulation
and
precise
release
capabilities,
are
emerging
as
pioneering
drug
delivery
systems.
This
study
introduces
a
hypoxia‐responsive
COF
designed
to
encapsulate
the
chemotherapy
gambogic
acid
(GA)
situ.
Bimetallic
gold‐palladium
islands
were
grown
on
UiO‐66‐NH
2
(UiO)
form
UiO@Au‐Pd
(UAPi),
which
encapsulated
with
GA
through
membrane
formation,
resulting
core‐shell
structure
(UAPiGC).
Further
modification
hyaluronic
(HA)
created
@GA‐COF@HA
(UAPiGCH)
enhanced
tumor
targeting.
In
hypoxic
microenvironment,
collapses,
releasing
UAPi,
initiating
triple
therapeutic
response:
nanozyme‐catalyzed
therapy,
near‐infrared
II
(NIR‐II)
mild
photothermal
therapy
(mild‐PTT),
chemotherapy.
UAPi
exhibits
catalase
(CAT)‐like
peroxidase
(POD)‐like
activities,
generating
oxygen
alleviate
hypoxia
reactive
species
(ROS)
destruction.
acts
chemotherapeutic
agent
inhibits
heat
shock
protein
90
(HSP90),
enhancing
sensitivity.
vitro
vivo
studies
confirm
UAPiGCH’s
ability
induce
pyroptosis,
stimulate
dendritic
cell
maturation,
boost
T
infiltration,
demonstrating
its
potential
nanoplatform.
strategy
integrates
multiple
therapies
into
system,
offering
promising
applications
cancer
treatment.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: Nov. 19, 2021
Abstract
The
past
decades
have
witnessed
great
progress
in
cancer
immunotherapy,
which
has
profoundly
revolutionized
oncology,
whereas
low
patient
response
rates
and
potential
immune‐related
adverse
events
remain
major
clinical
challenges.
With
the
advantages
of
controlled
delivery
modular
flexibility,
nanomedicine
offered
opportunities
to
strengthen
antitumor
immune
responses
sensitize
tumor
immunotherapy.
Furthermore,
tumor‐microenvironment
(TME)‐responsive
been
demonstrated
achieve
specific
localized
amplification
tissue
a
safe
effective
manner,
increasing
immunotherapy
reducing
side
effects
simultaneously.
Here,
recent
TME‐responsive
for
is
summarized,
responds
signals
TME,
such
as
weak
acidity,
reductive
environment,
high‐level
reactive
oxygen
species,
hypoxia,
overexpressed
enzymes,
adenosine
triphosphate.
Moreover,
combine
nanomedicine‐based
therapy
immunotherapeutic
strategies
overcome
each
step
cancer‐immunity
cycle
enhance
discussed.
Finally,
existing
challenges
further
perspectives
this
rising
field
with
hope
improved
development
applications
are
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: April 2, 2024
Abstract
Cancer
immunotherapy
and
vaccine
development
have
significantly
improved
the
fight
against
cancers.
Despite
these
advancements,
challenges
remain,
particularly
in
clinical
delivery
of
immunomodulatory
compounds.
The
tumor
microenvironment
(TME),
comprising
macrophages,
fibroblasts,
immune
cells,
plays
a
crucial
role
response
modulation.
Nanoparticles,
engineered
to
reshape
TME,
shown
promising
results
enhancing
by
facilitating
targeted
These
nanoparticles
can
suppress
fibroblast
activation,
promote
M1
macrophage
polarization,
aid
dendritic
cell
maturation,
encourage
T
infiltration.
Biomimetic
further
enhance
increasing
internalization
agents
cells
such
as
cells.
Moreover,
exosomes,
whether
naturally
secreted
body
or
bioengineered,
been
explored
regulate
TME
immune-related
affect
cancer
immunotherapy.
Stimuli-responsive
nanocarriers,
activated
pH,
redox,
light
conditions,
exhibit
potential
accelerate
co-application
with
checkpoint
inhibitors
is
an
emerging
strategy
boost
anti-tumor
immunity.
With
their
ability
induce
long-term
immunity,
nanoarchitectures
are
structures
development.
This
review
underscores
critical
overcoming
current
driving
advancement
modification.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: March 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(12), P. 4327 - 4347
Published: Nov. 4, 2022
Cancer
immunotherapy
has
significantly
flourished
and
revolutionized
the
limited
conventional
tumor
therapies,
on
account
of
its
good
safety
long-term
memory
ability.
Discouragingly,
low
patient
response
rates
potential
immune-related
side
effects
make
it
rather
challenging
to
literally
bring
from
bench
bedside.
However,
become
evident
that,
although
immunosuppressive
microenvironment
(TME)
plays
a
pivotal
role
in
facilitating
progression
metastasis,
also
provides
various
targets
for
remodeling
TME,
which
can
consequently
bolster
effectiveness
antitumor
suppression.
Additionally,
particular
characteristics
turn,
be
exploited
as
avenues
designing
diverse
precise
targeting
nanomedicines.
In
general,
is
urgent
necessity
deliver
nanomedicines
thus
improving
therapeutic
outcomes
clinical
translation
prospects
immunotherapy.
Herein,
we
will
illustrate
several
formation
mechanisms
TME.
More
importantly,
variety
strategies
concerning
TME
strengthening
patients'
immune
systems,
reviewed.
Ultimately,
discuss
existing
obstacles
future
perspectives
development
Hopefully,
thriving
bloom
vibrancy
further
exploration
comprehensive
cancer
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
12
Published: Aug. 29, 2022
Tumor
acidity
is
one
of
the
cancer
hallmarks
and
associated
with
metabolic
reprogramming
use
glycolysis,
which
results
in
a
high
intracellular
lactic
acid
concentration.
Cancer
cells
avoid
stress
major
by
activation
expression
proton
lactate
transporters
exchangers
have
an
inverted
pH
gradient
(extracellular
pHs
are
alkaline,
respectively).
The
shift
tumor
acid-base
balance
promotes
proliferation,
apoptosis
avoidance,
invasiveness,
metastatic
potential,
aggressiveness,
immune
evasion,
treatment
resistance.
For
example,
weak-base
chemotherapeutic
agents
may
substantially
reduced
cellular
uptake
capacity
due
to
"ion
trapping".
Lactic
negatively
affects
functions
activated
effector
T
cells,
stimulates
regulatory
them
express
programmed
cell
death
receptor
1.
On
other
hand,
inversion
could
be
weakness
that
will
allow
development
new
promising
therapies,
such
as
tumor-targeted
pH-sensitive
antibodies
pH-responsible
nanoparticle
conjugates
anticancer
drugs.
regulation
levels
pharmacological
inhibition
proteins
(monocarboxylate
transporters,
H
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(10)
Published: Feb. 2, 2023
Immunotherapy
is
an
attractive
treatment
strategy
for
cancer,
while
its
efficiency
and
safety
need
to
be
improved.
A
dual-cascade
activatable
nanopotentiator
sonodynamic
therapy
(SDT)
chemodynamic
(CDT)-cooperated
immunotherapy
of
deep
tumors
via
reshaping
adenosine
metabolism
herein
reported.
This
(NPMCA)
constructed
through
crosslinking
deaminase
(ADA)
with
chlorin
e6
(Ce6)-conjugated
manganese
dioxide
(MnO2)
nanoparticles
a
reactive
oxygen
species
(ROS)-cleavable
linker.
In
the
tumor
microenvironment
ultrasound
(US)
irradiation,
NPMCA
mediates
CDT
SDT
concurrently
in
covered
2-cm
tissues
produce
abundant
ROS,
which
results
scissoring
ROS-cleavable
linkers
activate
ADA
within
NCMCA
block
metabolism.
Moreover,
immunogenic
cell
death
(ICD)
dying
cells
upregulation
stimulator
interferon
genes
(STING)
triggered
by
generated
ROS
Mn2+
from
NPMCA,
respectively,
leading
activation
antitumor
immune
response.
The
potency
response
further
reinforced
reducing
accumulation
activated
ADA.
As
result,
enables
SDT-cooperated
immunotherapy,
showing
obviously
improved
therapeutic
efficacy
inhibit
growths
bilateral
tumors,
primary
are
tissues.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
59, P. 102601 - 102601
Published: Jan. 7, 2023
Hydrogen
sulfide
(H2S)
is
an
important
signaling
molecule
in
colorectal
cancer
(CRC).
It
produced
the
colon
by
catalytic
synthesis
of
colonocytes'
enzymatic
systems
and
release
intestinal
microbes,
oxidatively
metabolized
mitochondria.
Both
endogenous
H2S
colonic
epithelial
cells
exogenous
lumen
contribute
to
onset
progression
CRC.
The
up-regulation
synthetases
thought
be
cause
elevated
levels
CRC
cells.
Different
diagnostic
probes
combination
therapies,
as
well
tumor
treatment
approaches
through
modulation,
have
been
developed
recent
years
become
active
area
investigation
for
diagnosis
In
this
review,
we
focus
on
specific
mechanisms
production
oxidative
metabolism
function
occurrence,
progression,
diagnosis,
We
also
discuss
present
challenges
provide
insights
into
future
research
burgeoning
field.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(4), P. 3225 - 3258
Published: Feb. 6, 2023
The
immune
checkpoint
blockade
(ICB)
therapy
has
revolutionized
the
field
of
cancer
treatment,
while
low
response
rates
and
systemic
toxicity
limit
its
clinical
outcomes.
With
rapid
advances
in
nanotechnology
materials
science,
various
types
biomaterials
have
been
developed
to
maximize
therapeutic
efficacy
minimizing
side
effects
by
increasing
tumor
antigenicity,
reversing
immunosuppressive
microenvironment,
amplifying
antitumor
response,
reducing
extratumoral
distribution
inhibitors
as
well
enhancing
their
retention
within
target
sites.
In
this
review,
we
reviewed
current
design
strategies
for
different
augment
ICB
effectively
then
discussed
present
representative
biomaterial-assisted
modulation
targeted
delivery
boost
therapy.
Current
challenges
future
development
prospects
expanding
with
were
also
summarized.
We
anticipate
review
will
be
helpful
developing
emerging
promoting
application