Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Enhancing photodegradation of Methyl Orange by coupling piezo-phototronic effect and localized surface plasmon resonance

Nano Energy, Journal Year: 2023, Volume and Issue: 108, P. 108234 - 108234

Published: Jan. 26, 2023

Language: Английский

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Conferring BiVO₄ Nanorods with Oxygen Vacancies to Realize Enhanced Sonodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 9, 2022

Abstract Owing to the high depth of tissue penetration, non‐invasiveness, and controllability, ultrasound (US)‐mediated sonodynamic therapy (SDT) has shown broad application prospects for tumor treatment. However, electron‐hole separation inefficiency sonosensitizers hypoxia remain two major challenges limiting effect SDT. Here, ultrafine photoetched bismuth vanadate (BiVO 4 ) nanorods modified with DSPE‐PEG 2000 (PEBVO@PEG NRs) were fabricated achieve in situ self‐supply oxygen (O 2 reactive species (ROS) hypoxic therapy. The photoetching approach could enhance charge by inducing enriched vacancies on surface BiVO , thereby improving generation efficiency ROS O . PEBVO@PEG overcome main obstacles traditional SDT process show promising therapeutic effects, thus providing new strategies performance sonosensitizer elimination.

Language: Английский

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Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Oxygen‐Vacancy‐Rich Piezoelectric BiO_2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)

Published: April 14, 2023

Abstract Piezocatalytic therapy is a new‐emerging reactive oxygen species (ROS)‐enabled therapeutic strategy that relies on built‐in electric field and energy‐band bending of piezoelectric materials activated by ultrasound (US) irradiation. Despite becoming hot topic, material development mechanism exploration are still underway. Herein, as‐synthesized oxygen‐vacancy‐rich BiO 2− x nanosheets (NSs) demonstrate outstanding properties. Under US, piezo‐potential 0.25 V for NSs sufficient to tilt the conduction band be more negative than redox potentials O 2 / • − , /H H OH, which initiates cascade reaction ROS generation. Moreover, exhibit peroxidase oxidase‐like activities augment production, especially in ‐overexpressed tumor microenvironment. Density functional theory calculations show generated vacancies favorable adsorption increasing carrier density produce ROS. Furthermore, quick movement electrons enables an excellent sonothermal effect, example, rapid rise temperature nearly 65 °C upon US with low power (1.2 W cm −2 ) short time (96 s). Therefore, this system realizes multimode synergistic combination piezocatalytic, enzymatic, therapies, providing new direction defect engineering‐optimized therapy.

Language: Английский

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Selective Production of CO from Organic Pollutants by Coupling Piezocatalysis and Advanced Oxidation Processes

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(22)

Published: March 25, 2023

To date, the chemical conversion of organic pollutants into value-added feedstocks rather than CO2 remains a major challenge. Herein, we successfully developed coupled piezocatalytic and advanced oxidation processes (AOPs) system for achieving various to CO. The CO product stems from specific process in which organics are first oxidized carbonate through peroxymonosulfate (PMS)-based AOPs, then as-obtained is converted by piezoelectric reduction under ultrasonic (US) vibration using Co3 S4 /MoS2 catalyst. Experiments DFT calculations show that introduction not only effectively promotes transfer utilization electrons but also realizes highly selective /PMS has achieved generation actual complex wastewater treatment time, indicating its potential practical applicability.

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 16, 2023

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with highly catalytic and sonosensitive activities synergistic chemodynamic sonodynamic treatment TNBC. The single-atom Cu is anchored most stable Ti vacancies hollow TiO2 sonosensitizers, not only substantially improved activity Cu-mediated Fenton-like reaction, but also considerably augmented by facilitating separation electrons (e- holes (h+ ). Both in vitro vivo studies demonstrate that nanosonosensitizers effectively achieved inhibitory effect TNBC, providing paradigm non-invasive safe tumor elimination through mutual process sono/chemo-nanodynamic based multifunctional nanosonosensitizers.

Language: Английский

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