Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 25, 2024
Abstract
The
growth
state
of
tumor
cells
is
strictly
affected
by
the
specific
abnormal
redox
status
microenvironment
(TME).
Moreover,
reactions
at
biological
level
are
also
central
and
fundamental
to
essential
energy
metabolism
in
tumors.
Accordingly,
anti‐tumor
nanodrugs
targeting
disruption
this
homeostasis
have
become
one
hot
spots
field
research
due
effectiveness
TME
modulation
efficiency
mediated
interference.
This
review
discusses
latest
results
therapy,
which
regulate
levels
oxidants
or
reductants
through
a
variety
therapeutic
strategies,
ultimately
breaking
original
“stable”
promoting
cell
death.
With
gradual
deepening
study
on
vigorous
development
nanomaterials,
it
expected
that
more
nano
drugs
based
regulation
will
be
designed
even
applied
clinically.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(17)
Published: Jan. 2, 2024
Abstract
Gas
therapy,
represented
by
nitric
oxide
(NO),
has
shown
a
powerful
anti‐tumor
effect.
However,
current
NO
therapy
relies
on
precursors,
which
are
often
released
prematurely
during
in
vivo
delivery,
resulting
poor
targeting
and
obvious
toxic
side
effects.
Herein,
core/shell‐structured
nanocatalyst
is
designed
prepared
to
catalyze
the
generation
of
tumor
without
introduction
donor.
In
this
system,
C‐Z@CM
coating
octahedron
Cu‐MOF
with
nano‐ZnO,
camouflaging
homologous
cell
membrane.
After
nanomedicine
taken
up
cells,
ZnO
reacts
situ
endogenous
S‐nitrosoglutathione
(GSNO),
highly
expressed
tumors,
continuously
stably
generate
NO.
addition,
dispersed
copper
ions
acts
as
catalytic
active
centers
Fenton‐like
reaction,
catalyzes
H
2
O
large
number
hydroxyl
radicals
(
•
OH).
Importantly,
cascade
reactive
oxygen
species
(ROS)
leads
massive
production
more
lethal
nitrogen
(RNS),
further
enhancing
therapeutic
Catalytic
high
concentrations
tumor,
combined
ROS
RNS,
accompanied
glutathione
(GSH)
depletion,
achieving
effective
suppression.
Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
67(5), P. 3843 - 3859
Published: March 5, 2024
To
develop
a
potential
theranostic
metal
agent
to
reverse
the
resistance
of
cancer
cells
cisplatin
and
effectively
inhibit
tumor
growth
metastasis,
we
proposed
design
cyclometalated
iridium
(Ir)
complex
based
on
properties
environment
(TME).
end,
designed
synthesized
series
Ir(III)
2-hydroxy-1-naphthaldehyde
thiosemicarbazone
complexes
by
modifying
hydrogen
atom(s)
N-3
position
compounds
structure
dimers
then
investigated
their
structure–activity
structure–fluorescence
relationships
obtain
an
(Ir5)
with
remarkable
fluorescence
cytotoxicity
cells.
Ir5
not
only
possesses
mitochondria-targeted
but
also
overcomes
inhibits
metastasis
in
vivo.
Besides,
confirmed
anticancer
mechanisms
acting
different
components
TME:
directly
killing
liver
inducing
necroptosis
activating
necroptosis-related
immune
response.
Nanoscale Horizons,
Journal Year:
2024,
Volume and Issue:
9(10), P. 1630 - 1682
Published: Jan. 1, 2024
Many
pathological
conditions
are
predominantly
associated
with
oxidative
stress,
arising
from
reactive
oxygen
species
(ROS);
therefore,
the
modulation
of
redox
activities
has
been
a
key
strategy
to
restore
normal
tissue
functions.
Current
approaches
involve
establishing
favorable
cellular
environment
through
administration
therapeutic
drugs
and
redox-active
nanomaterials
(RANs).
In
particular,
RANs
not
only
provide
stable
reliable
means
delivery
but
also
possess
capacity
finely
tune
various
interconnected
components,
including
radicals,
enzymes,
proteins,
transcription
factors,
metabolites.
Here,
we
discuss
roles
that
engineered
play
in
spectrum
conditions,
such
as
cancer,
neurodegenerative
diseases,
infections,
inflammation.
We
visualize
dual
functions
both
generator
scavenger
ROS,
emphasizing
their
profound
impact
on
diverse
The
focus
this
review
is
solely
inorganic
(inorganic
RANs).
Additionally,
deliberate
challenges
current
RANs-based
propose
potential
research
directions
for
future
clinical
translation.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 14, 2024
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 25, 2024
Abstract
The
growth
state
of
tumor
cells
is
strictly
affected
by
the
specific
abnormal
redox
status
microenvironment
(TME).
Moreover,
reactions
at
biological
level
are
also
central
and
fundamental
to
essential
energy
metabolism
in
tumors.
Accordingly,
anti‐tumor
nanodrugs
targeting
disruption
this
homeostasis
have
become
one
hot
spots
field
research
due
effectiveness
TME
modulation
efficiency
mediated
interference.
This
review
discusses
latest
results
therapy,
which
regulate
levels
oxidants
or
reductants
through
a
variety
therapeutic
strategies,
ultimately
breaking
original
“stable”
promoting
cell
death.
With
gradual
deepening
study
on
vigorous
development
nanomaterials,
it
expected
that
more
nano
drugs
based
regulation
will
be
designed
even
applied
clinically.
