Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4081 - 4087

Published: Feb. 13, 2023

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form quadruple hydrogen-bonded agent. Detailed mechanism studies reveal intermolecular transfer charge separation upon light irradiation result efficient generation ion pairs. Under conditions, cationic radicals directly oxidize generate cytotoxic •OH, anionic electrons acid, realizing catalytic cycle. Thus, this exhibited superb photocytotoxicity even severe environments excellent vivo antitumor on HeLa-bearing mouse models. This work provides a strategy for constructing agents, opens up avenue effective PDT tumors.

Language: Английский

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Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Aug. 24, 2022

The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health, which drives researchers develop antibiotic-free strategies eradicate these fierce microbes. Although enormous achievements been achieved, it remains an arduous challenge realize efficient sterilization cut off the drug resistance generation. Recently, photothermal therapy (PTT) has emerged as promising solution efficiently damage integrity pathogenic based on hyperthermia beyond their tolerance. Until now, numerous agents studied for antimicrobial PTT. Among them, MXenes (a type two-dimensional transition metal carbides or nitrides) are extensively investigated one most candidates due high aspect ratio, atomic-thin thickness, excellent performance, low cytotoxicity, ultrahigh dispersibility in aqueous systems. Besides, application scenarios using antibacterial properties can be tailored via elaborated designs MXenes-based materials. In this review, synthetic approaches textural systematically presented first, then mechanisms materials documented. Subsequently, recent progress diverse fields making use performances well summarized reveal potential applications various purposes, including vitro vivo sterilization, solar water evaporation purification, flexible fabrics. Last but not least, current challenges future perspectives discussed provide theoretical guidance fabrication systems MXenes.

Language: Английский

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Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

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Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 19, 2022

Abstract Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare PSs is of great importance, but remains a challenge. Here, we report supramolecular strategy for the preparation photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors existing Type-II PSs. As proof-of-concept, three were designed co-assembled with classical PS produce quadruple hydrogen-bonded agents. The photo-induced transfer from adjacent acceptor occurs efficiently, leading generation +• an anionic radical acceptor, further transfers oxygen form O 2 −• . In addition, these agents induce direct photocatalytic oxidation NADH turnover frequency as high 53.7 min −1 , offers oxygen-independent mechanism damage tumors.

Language: Английский

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Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9110 - 9125

Published: May 5, 2023

Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological scenarios by hypoxia-resistant photosensitizer (PS) is cornerstone to conquer inevitable tumor recurrence and metastasis. Herein, we describe an organic NIR-II PS (TPEQM-DMA) possessing potent type-I phototherapeutic efficacy overcome intrinsic pitfalls PDT combating hypoxic tumors. TPEQM-DMA exhibited prominent emission (>1000 nm) with aggregation-induced feature efficiently produced superoxide anion hydroxyl radical aggregate state under white light irradiation exclusively through low-O2-dependent photochemical process. The suitable cationic nature assisted accumulate cancerous mitochondria. Meanwhile, impaired cellular redox homeostasis, led mitochondrial dysfunction, raised level lethal peroxidized lipids, which induced apoptosis ferroptosis. This synergistic cell death modality enabled suppress growth cells, multicellular spheroids, To improve pharmacological properties TPEQM-DMA, nanoparticles were prepared encapsulation polymer. In vivo experiments proved appealing fluorescence imaging-guided effect

Language: Английский

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De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 145(1), P. 334 - 344

Published: Dec. 27, 2022

Phototheranostics has received sustained attention due to its great potential in revolutionizing conventional strategies of cancer treatment. However, trapped by the complexity, poor reproducibility, insufficient phototheranostic outputs, and inevitable damage normal tissue most multicomponent systems, clinical translation been severely hindered. Therefore, exploration "one for all" smart agents with versatile functionalities remains an appealing yet enormously challenging task. Herein, a reversibly pH-switchable near-infrared second photosensitizer featuring aggregation-induced emission was tactfully designed molecular engineering precise tumor-targeting fluorescence imaging-guided phototherapy. Thanks strong intramolecular charge transfer, enhanced highly efficient intersystem crossing, sufficient motion, developed agent DTTVBI endowed boosted type-I superoxide anion radical generation excellent photothermal performance under 808 nm laser irradiation. More importantly, nanoparticles high biocompatibility exhibit remarkably photodynamic/photothermal therapy tumor region, thus offering significant antitumor effects both vitro patient-derived xenograft model colon cancer. This work sheds new light on development superior phototheranostics therapy.

Language: Английский

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Antibacterial Carbon Dots: Mechanisms, Design, and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 13, 2023

Abstract The increase in antibiotic resistance promotes the situation of developing new antibiotics at forefront, while development non‐antibiotic pharmaceuticals is equally significant. In post‐antibiotic era, nanomaterials with high antibacterial efficiency and no drug make them attractive candidates for materials. Carbon dots (CDs), as a kind carbon‐based zero‐dimensional nanomaterial, are attracting much attention their multifunctional properties. abundant surface states, tunable photoexcited excellent photo‐electron transfer properties sterilization CDs feasible gradually emerging field. This review provides comprehensive insights into recent topics include mechanisms, design, optimization processes, potential practical applications also highlighted, such treatment bacterial infections, against biofilms, surfaces, food preservation, bacteria imaging detection. Meanwhile, challenges outlook field discussed proposed.

Language: Английский

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Chlorination‐Mediated π–π Stacking Enhances the Photodynamic Properties of a NIR‐II Emitting Photosensitizer with Extended Conjugation

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(25)

Published: April 20, 2023

NIR-II-emitting photosensitizers (PSs) have attracted great research interest due to their promising clinical applications in imaging-guided photodynamic therapy (PDT). However, it is still challenging realize highly efficient PDT on NIR-II PSs. In this work, we develop a chlorination-mediated π-π organizing strategy improve the of PS with conjugation-extended A-D-A architecture. The significant dipole moment carbon-chlorine bond and strong intermolecular interactions chlorine atoms bring compact stacking chlorine-substituted PS, which facilitates energy/charge transfer promotes photochemical reactions PDT. Consequently, resultant emitting exhibits leading performance yield reactive oxygen species higher than that previously reported long-wavelength These findings will enlighten future design PSs enhanced efficiency.

Language: Английский

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Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 17, 2023

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use active intramolecular motion-induced effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, extremely satisfactory behavior. Consequently, unprecedented performance NPs 1064 nm laser-excited photoacoustic imaging (PAI)-guided therapy (PTT) demonstrated tumor diagnosis complete elimination.

Language: Английский

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