Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers DOI Creative Commons
Jiahao Zhuang, Guobin Qi,

Yecheng Feng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Language: Английский

Deciphering Oxygen‐Independent Augmented Photodynamic Oncotherapy by Facilitating the Separation of Electron‐Hole Pairs DOI
Xiaoming Hu, Zhu-ting Fang,

Fengwei Sun

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(15)

Published: Feb. 16, 2024

Developing Type-I photosensitizers provides an attractive approach to solve the dilemma of inadequate efficacy photodynamic therapy (PDT) caused by inherent oxygen consumption traditional Type-II PDT and anoxic tumor microenvironment. The challenge for exploration PSs is facilitate electron transfer ability photosensitization molecules transforming or H

Language: Английский

Citations

22
NIR‐II Excitable Semiconducting Polymers with AIE Characteristics for Fluorescence‐Photoacoustic Imaging‐Guided Synergistic Phototherapy DOI
Jiangao Li, Zhijun Zhang, Shanshan Jiang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: March 22, 2024

Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar configuration commonly‐used electrophilic acceptor moieties. Herein, an ingenious dimerization‐based distortion strategy proposed current work by taking advantage sterically encumbered acceptors structure for successful construction AIE‐active SPs. Through further finely adjusting molecular donor–acceptor interaction strength, obtained named SP3 bearing highest intramolecular charge transfer effect presented NIR‐II aggregation‐induced fluorescence emission, good reactive oxygen species production ability, superior photothermal conversion performance. Accordingly, selected fabricate nanoparticles successfully applied laser‐triggered fluorescence‐photoacoustic imaging‐guided photodynamic‐photothermal therapy tumors. This study represents first excitable SP, offers a new perspective on designing advanced efficient treatment malignant tumor.

Language: Английский

Citations

20
Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy DOI

Siqin Chen,

Bowen Li,

Yifan Yue

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, a novel nanoplatform, LipoHPM, designed to address these challenges, is reported. This approach employs an acid‐sensitive amine linker connect biotin‐modified hydrophilic polymer ( Biotin PEG) with new hydrophobic photosensitizer (MBA), forming OFF‐state P EG‐ M BA (PM) micelles via aggregation‐caused quenching (ACQ) These are then co‐loaded the tumor penetration enhancer hydralazine H DZ) into pH‐sensitive liposomes (Lipo HPM ). Leveraging ACQ effect, LipoHPM silent both fluorescence reactive oxygen species (ROS) generation during blood circulation but restores properties upon disassembly. Following intravenous injection tumor‐bearing mice, actively targets cells overexpressing biotin‐receptors, contributing enhanced accumulation. Upon cellular internalization, disassembles within lysosomes, releasing HDZ enhance inhibit metastasis. Concurrently, activate boost production of type‐I type‐II ROS eradication. Therefore, smart synergistically integrates near‐infrared emission, activatable imaging, robust generation, efficient anti‐metastasis activity, successfully overcoming limitations conventional photosensitizers establishing itself as promising nanoplatform potent FIG‐PDT applications.

Language: Английский

Citations

20
Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy DOI

Weiguo Qiao,

Teng Ma,

Ge Xie

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25671 - 25684

Published: Sept. 3, 2024

Combined photodynamic and photothermal therapy (PDT PTT) can achieve more superior therapeutic effects than the sole mode by maximizing photon utilization, but there remains a significant challenge in development of related single-molecule photosensitizers (PSs), particularly those with type I photosensitization. In this study, self-assembly squaraine dyes (SQs) is shown to be promising strategy for designing PSs combined PDT PTT, supramolecular PS (TPE-SQ7) has been successfully developed through subtle molecular design an indolenine SQ, which self-assemble into highly ordered H-aggregates aqueous solution as well nanoparticles (NPs). contrast typical quenching effect on reactive oxygen species (ROS) generation, our results encouragingly manifest that enhance ROS (

Language: Английский

Citations

18
Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers DOI Creative Commons
Jiahao Zhuang, Guobin Qi,

Yecheng Feng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Language: Английский

Citations

17