Metal‐based smart nanosystems in cancer immunotherapy DOI Creative Commons
Ying Luo,

Xiaojing He,

Qianying Du

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Language: Английский

Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy DOI Creative Commons

Huali Lei,

Zifan Pei, Chenyu Jiang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Language: Английский

Citations

94
Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response DOI
Mingle Li, Jungryun Kim, Hyeonji Rha

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(11), P. 6007 - 6023

Published: March 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Language: Английский

Citations

88
Bioorthogonal-Activated In Situ Vaccine Mediated by a COF-Based Catalytic Platform for Potent Cancer Immunotherapy DOI
Mengyu Sun, Zhengwei Liu, Li Wu

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(9), P. 5330 - 5341

Published: Feb. 23, 2023

Personalized tumor vaccines have become a promising modality for cancer immunotherapy. However, in situ personalized generated from immunogenic cell death (ICD) and adjuvants are mired by toxic side effects unsatisfactory efficiency. Herein, functionalizing the reticular structure to optimize catalytic activity of materials, series biocompatible covalent organic framework (COF)-based catalysts been designed screened establishing bioorthogonal-activated vaccine an efficient safe way. Especially, pro-doxorubicin (pro-DOX) could be bioorthogonally activated COF-based Fe(II) catalysts, which elicited ICD released tumor-associated antigens (TAAs). This prodrug activation strategy minimize drug maximize treatment effects. More importantly, system also catalytically activate pro-imiquimod (pro-IMQ, TLR7/8 immune agonist), served as adjuvant amplify antitumor immunity. Notably, this not only facilitated strong response but prevented dose-dependent chemotherapeutic drugs, including systemic inflammation caused random distribution adjuvants. To best our knowledge, it is first time devise platform generating vaccine, would provide paradigm achieving secure robust

Language: Английский

Citations

84
Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications DOI Creative Commons
Nem Singh, Jungryun Kim, Jaewon Kim

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 358 - 380

Published: Sept. 14, 2022

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have massive potential in solving longstanding challenges existing drugs, such as poor localization at the tumor site, high doses toxicity, recurrence, immune response. However, inadequate biocompatibility restricts their clinical translation. Therefore, advanced nanomaterials with enhanced therapeutic efficiency are highly desired to fast-track translation nanomedicines. Intrinsic nanoscale covalent organic frameworks (nCOFs), suitable size, modular pore geometry porosity, straightforward post-synthetic modification via simple transformations, make them incredibly attractive future ability COFs disintegrate slightly acidic microenvironment also gives competitive advantage targeted delivery. This review summarizes recently published applications delivery, photo-immuno therapy, sonodynamic photothermal chemotherapy, pyroptosis, combination therapy. Herein we mainly focused on modifications enhance biocompatibility, efficacy will provide fundamental knowledge designing biocompatible nCOFs-based help rapid development carriers theranostics.

Language: Английский

Citations

82
Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy DOI
Bin Zhang, Zhengwei Liu, Jiawei Zhu

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(30), P. 16658 - 16668

Published: July 24, 2023

Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and self-protective mechanism cells significantly weakens therapeutic efficiency. Here, a bioorthogonal nanoregulator constructed to induce disrupt checkpoint, enabling high-efficiency The allows situ synthesis accumulation photosensitizer PpIX mitochondria directly produce mitochondrial ROS, thus triggering pyroptosis. Meanwhile, generated inhibitor via palladium-catalyzed chemistry can boost efficacy. With biomimetic membrane coating, this platform for modulating presents specificity poses no harm normal tissue, resulting highly efficient safe antitumor treatment. To our knowledge, first report on disrupting intrinsic protective tumor This work highlights plays key regulative role therapy, which would motivate future design regimens.

Language: Английский

Citations

59
Activation of Pyroptosis Using AIEgen-Based sp2 Carbon-Linked Covalent Organic Frameworks DOI
Liang Zhang, Shu‐Cheng Wan, Jianyu Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(32), P. 17689 - 17699

Published: Aug. 8, 2023

Covalent organic frameworks (COFs) have emerged as a promising class of crystalline porous materials for cancer phototherapy, due to their exceptional characteristics, including light absorption, biocompatibility, and photostability. However, the aggregation-caused quenching effect apoptosis resistance often limit therapeutic efficacy. Herein, we demonstrated first time that linking luminogens with aggregation-induced emission (AIEgens) into COF networks via vinyl linkages was an effective strategy construct nonmetallic pyroptosis inducers boosting antitumor immunity. Mechanistic investigations revealed formation linkage in AIE endowed it not only high brightness but also strong absorption ability, long lifetime, quantum yield favor generation reactive oxygen species eliciting pyroptosis. In addition, synergized system αPD-1 effectively eradicated primary distant tumors inhibited tumor recurrence metastasis bilateral 4T1 model.

Language: Английский

Citations

56
Pt nanozyme-bridged covalent organic framework-aptamer nanoplatform for tumor targeted self-strengthening photocatalytic therapy DOI
Peng Gao, Ruyue Wei, Yuanyuan Chen

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 297, P. 122109 - 122109

Published: April 4, 2023

Language: Английский

Citations

51
A Metal–Phenolic Nanocoordinator Launches Radiotherapeutic Cancer Pyroptosis Through an Epigenetic Mechanism DOI
Guohao Wang, Bei Li, Hao Tian

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(23)

Published: March 16, 2023

Abstract Radiotherapy, although clinically effective in immunoactivation, still cannot radio‐functionalize tumor as a potent immunogenetic center. Given that newly found pyroptosis efficiently releases immunogenic damage‐associated molecular patterns, initiating radiotherapeutic may turn vision of radiotherapy‐induced immunity into reality. However, precondition is the absent gasdermin E (GSDME), which essentiates caspase‐3‐mediated pyroptosis, can be well translated cancer cells. Here, an epigenetic strategy to launch radiotherapy introduced. The nanocoordinator (PWE) constructed via metal–phenolic coordination between polyphenolic DNA methyltransferase inhibitor (epigallocatechin‐3‐gallate, EGCG), high‐Z radiosensitizer (W 6+ ), and polyphenol‐modified block copolymer. While recovering GSDME expression by EGCG, PWE cleaves fragmented N‐terminal (pyroptotic key protein) caspase‐3. To examine anti‐tumor immune activities, amplifies immunological effects traditional decreases radiotherapy‐upregulated regulatory T cells, providing new insight radiotherapy.

Language: Английский

Citations

50
Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy DOI
Ji‐Na Hao,

Kaiming Ge,

Guoli Chen

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(22), P. 7707 - 7736

Published: Jan. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Language: Английский

Citations

50
Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy DOI Open Access

Feixiang Ding,

Junyan Liu, Kelong Ai

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 5, 2023

Promoting innate immunity through pyroptosis induction or the cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) pathway activation has emerged as a potent approach to counteract immunosuppressive tumor microenvironment and elicit systemic antitumor immunity. However, current inducers STING agonists often suffer from limitations including instability, unpredictable side effects, inadequate intracellular expression gasdermin STING. Here, tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic simultaneously activate cGAS-STING in light-controlled manner is constructed. This involves development oxidation-sensitive nanoparticles (NP1) loaded photosensitizer TBE, along decitabine nanomicelles (NP2). NP2 enables restoration E (GSDME) expression, while NP1-mediated PDT facilitates release DNA fragments damaged mitochondria potentiate pathway, promotes caspase-3 cleave upregulated GSDME into pore-forming GSDME-N terminal. Subsequently, released inflammatory cytokines facilitate maturation antigen-presentation cells, triggering T cell-mediated Overall, this study presents an elaborate strategy for simultaneous photoactivation enabling targeted photoimmunotherapy immunotolerant tumors. innovative holds significant promise overcoming associated existing therapeutic modalities represents valuable avenue future clinical applications.

Language: Английский

Citations

48