Aggregate,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: Jan. 22, 2024
Abstract
The
induction
of
regulated
cell
death
(RCD)
through
photo/ultrasound
sensitization
therapeutic
agents
has
gained
significant
attention
as
a
vital
approach
to
combat
drug
resistance
in
tumors.
Aggregation‐induced
emission
(AIE)
generate
reactive
oxygen
species
activation,
which
can
synergize
with
RCD
inducers
or
directly
induce
RCD,
ultimately
resulting
the
tumor
cells.
presented
comprehensive
review
delves
into
recent
advancements
AIE
designed
trigger
inducers,
encompassing
apoptosis,
necroptosis,
pyroptosis,
immunogenic
death,
autophagy,
ferroptosis,
and
cuproptosis.
Additionally,
intricate
regulatory
mechanisms
activatory‐AIE
therapeutics
influence
distinct
pathways
are
examined.
A
forward‐looking
perspective
on
future
developments
pertinent
challenges
within
this
exciting
realm
is
presented,
anticipating
continued
evolution
activatable
transformative
enhance
therapy.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5607 - 5651
Published: Jan. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(13), P. 4392 - 4442
Published: Jan. 1, 2023
Metal
agents
have
made
incredible
strides
in
preclinical
research
and
clinical
applications,
but
their
short
emission/absorption
wavelengths
continue
to
be
a
barrier
distribution,
therapeutic
action,
visual
tracking,
efficacy
evaluation.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(8)
Published: Oct. 11, 2023
Abstract
Activating
the
strong
immune
system
is
a
key
initiative
to
counteract
dormant
tumors
and
prevent
recurrence.
Herein,
self‐destructive
multienzymatically
active
copper‐quinone‐GOx
nanoparticles
(abbreviated
as
CQG
NPs)
have
been
designed
induce
harmonious
balanced
pyroptosis
cuproptosis
using
“Tai
Chi
mindset”
awaken
response
for
suppressing
recurrent
tumors.
This
cleverly
material
can
disrupt
antioxidant
defense
mechanism
of
tumor
cells
by
inhibiting
nuclear
factor‐erythroid
2‐related
factor
2
(NRF2)‐quinone
oxidoreductase
1
(NQO1)
signaling
pathway.
Furthermore,
combined
with
its
excellent
multienzyme
activity,
it
activates
NOD‐like
receptor
protein
3
(NLRP3)‐mediated
pyroptosis.
Meanwhile,
be
triggered
copper
ions
released
from
disintegration
NPs
sensitivity
cancer
enhanced
through
depletion
endogenous
chelators
via
Michael
addition
reaction
between
glutathione
(GSH)
quinone
ligand,
oxygen
production
catalase‐like
reaction,
starvation‐induced
glucose
deficiency.
More
importantly,
NPs‐induced
promote
immunosuppressive
microenvironment
(TME)
remodeling,
enhance
infiltration
into
tumor,
activate
robust
systemic
immunity.
Collectively,
this
study
provides
new
strategy
resist
dormancy,
recurrence,
improve
clinical
prognosis
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(30), P. 16658 - 16668
Published: July 24, 2023
Pyroptosis
is
an
inflammatory
form
of
programmed
cell
death
that
holds
great
promise
in
cancer
therapy.
However,
autophagy
as
the
crucial
pyroptosis
checkpoint
and
self-protective
mechanism
cells
significantly
weakens
therapeutic
efficiency.
Here,
a
bioorthogonal
nanoregulator
constructed
to
induce
disrupt
checkpoint,
enabling
high-efficiency
The
allows
situ
synthesis
accumulation
photosensitizer
PpIX
mitochondria
directly
produce
mitochondrial
ROS,
thus
triggering
pyroptosis.
Meanwhile,
generated
inhibitor
via
palladium-catalyzed
chemistry
can
boost
efficacy.
With
biomimetic
membrane
coating,
this
platform
for
modulating
presents
specificity
poses
no
harm
normal
tissue,
resulting
highly
efficient
safe
antitumor
treatment.
To
our
knowledge,
first
report
on
disrupting
intrinsic
protective
tumor
This
work
highlights
plays
key
regulative
role
therapy,
which
would
motivate
future
design
regimens.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(16), P. 15605 - 15614
Published: July 28, 2023
Immunotherapy
is
an
advanced
therapeutic
strategy
of
cancer
treatment
but
suffers
from
the
issues
off-target
adverse
effects,
lack
real-time
monitoring
techniques,
and
unsustainable
response.
Herein,
ultrasmall
Au
nanocluster
(NC)-based
theranostic
probe
designed
for
second
near-infrared
window
(NIR-II)
photoluminescence
(PL)
imaging-guided
phototherapies
photoactivatable
immunotherapy.
The
(Au44MBA26-NLG
short)
composed
atomically
precise
NIR-II
emitting
Au44MBA26
NCs
(here
MBA
denotes
water-soluble
4-mercaptobenzoic
acid)
conjugated
with
immune
checkpoint
inhibitor
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
(NLG919)
via
a
singlet
oxygen
(1O2)-cleavable
linker.
Upon
NIR
photoirradiation,
Au44MBA26-NLG
not
only
enables
PL
imaging
tumors
in
deep
tissues
guiding
tumor
therapy
also
allows
leverage
photothermal
property
(PTT)
photogenerated
1O2
photodynamic
(PDT)
releasing
NLG919
Such
multiple
effect
modulated
by
prompts
proliferation
activation
effector
T
cells,
upshifts
systemic
antitumor
T-lymphocyte
(T
cell)
immunity,
finally
suppresses
growth
both
primary
distant
living
mice.
Overall,
this
study
may
provide
promising
nanoplatform
toward
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17689 - 17699
Published: Aug. 8, 2023
Covalent
organic
frameworks
(COFs)
have
emerged
as
a
promising
class
of
crystalline
porous
materials
for
cancer
phototherapy,
due
to
their
exceptional
characteristics,
including
light
absorption,
biocompatibility,
and
photostability.
However,
the
aggregation-caused
quenching
effect
apoptosis
resistance
often
limit
therapeutic
efficacy.
Herein,
we
demonstrated
first
time
that
linking
luminogens
with
aggregation-induced
emission
(AIEgens)
into
COF
networks
via
vinyl
linkages
was
an
effective
strategy
construct
nonmetallic
pyroptosis
inducers
boosting
antitumor
immunity.
Mechanistic
investigations
revealed
formation
linkage
in
AIE
endowed
it
not
only
high
brightness
but
also
strong
absorption
ability,
long
lifetime,
quantum
yield
favor
generation
reactive
oxygen
species
eliciting
pyroptosis.
In
addition,
synergized
system
αPD-1
effectively
eradicated
primary
distant
tumors
inhibited
tumor
recurrence
metastasis
bilateral
4T1
model.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(13), P. 8991 - 9003
Published: March 21, 2024
Though
immunogenic
cell
death
(ICD)
has
garnered
significant
attention
in
the
realm
of
anticancer
therapies,
effectively
stimulating
strong
immune
responses
with
minimal
side
effects
deep-seated
tumors
remains
challenging.
Herein,
we
introduce
a
novel
self-assembled
near-infrared-light-activated
ruthenium(II)
metallacycle,
Ru1105
(λem
=
1105
nm),
as
first
example
Ru(II)
supramolecular
ICD
inducer.
synergistically
potentiates
immunomodulatory
and
reduces
adverse
through
multiple
regulated
approaches,
including
NIR-light
excitation,
increased
reactive
oxygen
species
(ROS)
generation,
selective
targeting
tumor
cells,
precision
organelle
localization,
improved
penetration/retention
capabilities.
Specifically,
demonstrates
excellent
depth-activated
ROS
production
(∼1
cm),
resistance
to
diffusion,
anti-ROS
quenching.
Moreover,
exhibits
promising
results
cellular
uptake
generation
cancer
cells
multicellular
spheroids.
Importantly,
induces
more
efficient
an
ultralow
dose
(10
μM)
compared
conventional
agent,
oxaliplatin
(300
μM).
In
vivo
experiments
further
confirm
Ru1105's
potency
inducer,
eliciting
CD8+
T
depleting
Foxp3+
effects.
Our
research
lays
foundation
for
design
secure
exceptionally
potent
metal-based
agents
immunotherapy.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(13), P. 9413 - 9421
Published: March 20, 2024
Precise
control
of
cellular
signaling
events
during
programmed
cell
death
is
crucial
yet
challenging
for
cancer
therapy.
The
modulation
signal
transduction
in
cells
holds
promise
but
limited
by
the
lack
efficient,
biocompatible,
and
spatiotemporally
controllable
approaches.
Here
we
report
a
photodynamic
strategy
that
modulates
both
apoptotic
pyroptotic
altering
caspase-3
protein
activity
associated
crosstalk.
This
employs
mitochondria-targeting,
near-infrared
activatable
probe
(termed
M-TOP)
functions
via
type-I
photochemical
mechanism.
M-TOP
less
dependent
on
oxygen
more
effective
treating
drug-resistant
cells,
even
under
hypoxic
conditions.
Our
study
shows
higher
doses
induce
caspase-3/gasdermin-E
pathway,
whereas
lower
lead
to
apoptosis.
method
across
diverse
gasdermin-E-expressing
cells.
Moreover,
mediated
shift
from
can
evoke
controlled
inflammatory
response,
leading
robust
balanced
immune
reaction.
effectively
inhibits
distal
tumor
growth
postsurgical
recurrence.
work
demonstrates
feasibility
modulating
intracellular
through
rational
design
anticancer
drugs.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(15), P. 10542 - 10556
Published: April 1, 2024
Immunotherapy
has
emerged
as
a
potential
approach
for
breast
cancer
treatment.
However,
the
rigid
stromal
microenvironment
and
low
immunogenicity
of
tumors
strongly
reduce
sensitivity
to
immunotherapy.
To
sensitize
patients
immunotherapy,
hyaluronic
acid-modified
zinc
peroxide–iron
nanocomposites
(Fe-ZnO2@HA,
abbreviated
FZOH)
were
synthesized
remodel
increase
tumor
immunogenicity.
The
constructed
FZOH
spontaneously
generated
highly
oxidative
hydroxyl
radicals
(·OH)
that
degrade
acid
(HA)
in
extracellular
matrix
(ECM),
thereby
reshaping
enhancing
blood
perfusion,
drug
penetration,
immune
cell
infiltration.
Furthermore,
not
only
triggers
pyroptosis
through
activation
caspase-1/GSDMD-dependent
pathway
but
also
induces
ferroptosis
various
mechanisms,
including
increasing
levels
Fe2+
intracellular
iron
pool,
downregulating
expression
FPN1
inhibit
efflux,
activating
p53
signaling
cause
failure
SLC7A11-GSH-GPX4
axis.
Upon
treatment
with
FZOH,
4T1
cells
undergo
both
pyroptosis,
exhibiting
strong
immunogenic
response.
remodeling
response
induced
by
collectively
compensate
limitations
immunotherapy
significantly
enhance
antitumor
checkpoint
inhibitor
αPD-1.
This
study
proposes
perspective
therapy
cancer.
Aggregate,
Journal Year:
2024,
Volume and Issue:
5(2)
Published: Jan. 4, 2024
Abstract
The
development
of
efficient
drug
delivery
systems
is
essential
for
improving
the
efficacy
and
safety
cancer
drugs,
particularly
aggressive
difficult‐to‐treat
cancers.
Covalent
organic
frameworks
(COFs)
are
emerging
as
innovative
porous
nanomaterials
in
(DDS),
due
to
their
unique
properties,
including
metal‐free
skeleton,
predetermined
structures
pore
geometries,
high
porosity,
large
surface
area,
facile
modification
potential,
good
biocompatibility.
These
characteristics
make
COFs
excellent
candidates
by
enhancing
loading
capacity
enabling
precise
encapsulation.
This
review
emphasizes
importance
donor‐acceptor‐based
COFs,
which
provide
channels
charge
transportation,
we
also
explore
how
π‐conjugated
skeleton
enhances
its
long‐acting
fluorescent
properties
facilitates
uptake
via
cell
endocytosis.
While
this
primarily
focuses
on
recent
advancements
COF‐based
targeted
DDS,
it
acknowledges
challenges
posed
diverse
geometries
materials
discusses
potential
solutions.
Further,
underlines
developing
future
carriers
that
can
successfully
specifically
target
cells,
treatment
efficiency
while
reducing
adverse
side
effects.