Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.

Language: Английский

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A smart adhesive Janus hydrogel for non-invasive cardiac repair and tissue adhesion prevention

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 12, 2022

Abstract Multifunctional hydrogel with asymmetric and reversible adhesion characteristics is essential to handle the obstructions towards bioapplications of trauma removal postoperative tissue synechia. Herein, we developed a responsively asymmetrically adhesive Janus that enables on-demand stimuli-triggered detachment for efficient myocardial infarction (MI) repair, synchronously prevents synechia inflammatory intrusion after surgery. In contrast most irreversibly hard-to-removable adhesives, this exhibited capability can be noninvasively detached just by slight biologics. It interesting behaves molecularly encoded adhesion-adaptive stiffening feature similar self-protective stress–strain effect biological tissues. vitro in vivo experiments demonstrated promote maturation functions cardiomyocytes, facilitate MI repair reducing oxidative damage response, reconstructing electrical conduction blood supply infarcted area. Furthermore, no secondary injury were triggered transplantation hydrogel. This smart reported herein offers potential strategy clinically transformable cardiac patch anti-postoperative barrier.

Language: Английский

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Toughening Double‐Network Hydrogels by Polyelectrolytes

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)

Published: March 20, 2023

The Hoffmeister effect of inorganic salts is verified as a promising way to toughen hydrogels, however, the high concentration may be accompanied by poor biocompatibility. In this work, it found that polyelectrolytes can obviously elevate mechanical performances hydrogels through effect. introduction anionic poly(sodium acrylate) into poly(vinyl alcohol) (PVA) hydrogel induces aggregation and crystallization PVA boost properties resulting double-network hydrogel: elevation 73, 64, 28, 135, 19 times in tensile strength, compressive Young's modulus, toughness, fracture energy compared with poly(acrylic acid), respectively. It noteworthy flexibly tuned variation polyelectrolyte concentration, ionization degree, relative hydrophobicity ionic component, type wide range. This strategy work for other Hoffmeister-effect-sensitive polymers polyelectrolytes. Also, urea bonds further improve antiswelling capability hydrogels. As biomedical patch, advanced efficiently inhibit hernia formation promote regeneration soft tissues an abdominal wall defect model.

Language: Английский

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An Integrally Formed Janus Hydrogel for Robust Wet‐Tissue Adhesive and Anti‐Postoperative Adhesion

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 16, 2023

Facile fabrication of asymmetrically adhesive hydrogel with robust wet tissue adhesion simultaneously effective anti-postoperative still remains a great challenge. In this work, an integrally formed Janus is facilely fabricated in one step by controlling the interfacial distribution free carboxyl groups on two sides hydrogels. At lower stirring speed, generated bigger sized emulsion droplets mainly occupy top surface hydrogel, which effectively hinders exposition surface, driving them to be more distributed bottom ultimately resulting poor but various even underwater. The difference strength achieves as high 20 times between surfaces. vivo rabbit experiment outcomes clearly validate that firmly adheres stomach defect, and other opposite can efficiently address postoperative problem. Besides, exhibits superior mechanical toughness conductivity has been used highly strain sensor real-time monitor beating heart vivo. This simple yet strategy provides much feasible approach for creating hydrogels bioadhesives.

Language: Английский

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Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 387 - 412

Published: March 17, 2023

Postoperative adhesion (POA) widely occurs in soft tissues and usually leads to chronic pain, dysfunction of adjacent organs some acute complications, seriously reducing patients' quality life even being life-threatening. Except for adhesiolysis, there are few effective methods release existing adhesion. However, it requires a second operation inpatient care triggers recurrent great incidence. Hence, preventing POA formation has been regarded as the most clinical strategy. Biomaterials have attracted attention because they can act both barriers drug carriers. Nevertheless, though much reported research demonstrated their efficacy on inhibition certain extent, thoroughly is still challenging. Meanwhile, biomaterials prevention were designed based limited experiences, not solid theoretical basis, showing blindness. we aimed provide guidance designing anti-adhesion materials applied different mechanisms occurrence development. We first classified postoperative adhesions into four categories according components diverse tissues, named them "membranous adhesion", "vascular "adhesive adhesion" "scarred respectively. Then, process development analyzed, main influencing factors stages clarified. Further, proposed seven strategies by using these factors. relevant practices summarized corresponding future perspectives analyzed.

Language: Английский

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A Unified Therapeutic–Prophylactic Tissue‐Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 20, 2023

Osteosarcoma occurs in children and adolescents frequently leads to a high fatality rate. Although surgical resection is the most common methods clinic, patients always suffer from tumor metastasis recurrence it difficult for them self-repair large bone defects. Furthermore, postoperative infection bacteria triggers an inflammatory response hinders bone-repair process. This work demonstrates gadolinium (Gd)-complex molybdenum sulfide (MoS2 ) co-doped N-acryloyl glycinamide (NAGA)/gelatin methacrylate (Gel-MA) multifunctional hydrogel (GMNG). The combination between NAGA Gel-MA endows GMNG with attractive mechanical properties controllable degradation ability. MoS2 improves system, which has excellent photothermal ability kill cells inhibit bacterial both vitro vivo. Based on Gd-complex, magnetic resonance imaging (MRI) effect can be used monitor position situation of hydrogel. Notably, accompanied by hydrogel, gradually released Gd3+ exhibits osteogenic property could promote new formation efficiently Therefore, this strategy supplies method prepare bone-defect-repair materials expected represent significant guidance reference development biomaterials tissue engineering.

Language: Английский

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A Rapid Self‐Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 15, 2023

Abstract Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self‐pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive ≈30 times enhancement in efficiency compared the pure hydrogel, effectively promote burn A creaming‐assistant emulsion interfacial polymerization approach proposed to create hydrogel through dynamic floating‐colliding‐coalescing process of organogel precursor droplets. In murine model, rapid markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration ≈6.6 times, hair follicle ≈13.5 commercial (Tegaderm). This study paves an avenue designing high‐performance functional dressings.

Language: Английский

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Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management

Advanced Science, Journal Year: 2023, Volume and Issue: 10(25)

Published: June 27, 2023

Abstract Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most them still lack satisfactory controllability comprehensive functionality. Herein, inspired by multiple creatures, including octopuses snails, a novel muti‐functional patch is presented with controlled adhesion, antibacterial, drug release features, monitoring functions for intelligent healing management. The micro suction‐cup actuator array tensile backing layer composed tannin grafted gelatin, Ag‐tannin nanoparticles, polyacrylamide (PAAm) poly( N ‐isopropylacrylamide) (PNIPAm). In virtue photothermal gel‐sol transition gelatin exert dual anti‐microbial effect temperature‐sensitive snail mucus‐like features. addition, as “suction‐cups” consisting thermal responsive PNIPAm can undergo contract‐relax transformation, medical adhere objects reversibly responsively, their loaded vascular endothelial growth factor (VEGF) controllably healing. More attractively, benefiting from fatigue resistance, self‐healing ability double network hydrogel, electrical conductivity proposed report physiology parameters sensitively continuously. Thus, it believed that this multi‐bioinspired has immense potential future

Language: Английский

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Establishments and Evaluations of Post‐Operative Adhesion Animal Models

Advanced Therapeutics, Journal Year: 2023, Volume and Issue: 6(4)

Published: Feb. 4, 2023

Abstract After abdominopelvic surgery, there are 90–93% of patients who develop postoperative adhesions. Post‐operative adhesions can occur after various surgical procedures, which not only cause a series complications but also increase the economic burden patients. Based on US FDA rules, anti‐adhesive products need to be deeply evaluated for their bio‐functionality in animal models before clinic entrance. However, date, few literatures systematically summarizing establish approaches and evaluation standards post‐operative adhesion models. Therefore, according importance knowledge related vivo models, this manuscript, occurrence mechanism is reviewed, followed by construction methods at different organs, then common indicators including scores histological characterization listed. This review reference characterizations materials.

Language: Английский

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