Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(32), P. 17881 - 17891

Published: Aug. 2, 2023

Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition fiber caps induced cysteine cathepsin. However, accurate measurement cathepsin B (CTB) activity in plaques challenging due to low specificity insufficient penetration depth available atherosclerosis-associated fluorescent probes, hampering reliable assessment vulnerability. To address these limitations, we added both lipophilic alkyl chain hydrophilic CTB substrate hemicyanine scaffold develop lipid-unlocked responsive probe (L-CRP) that uses lipids two keys unlock photoacoustic (PA) signals for measuring environments. Such properties allow L-CRP imaging specific activities foam cells atherosclerotic while keeping silence toward lipid-deficient environments, M1-type macrophages LPS-induced inflammatory lesions. Moreover, activatable PA exhibit deeper tissue ability (>1.0 cm) than current probes based on near-infrared (∼0.3 cm), suitable atherosclerosis living mice. In mice, dynamically reports intraplaque levels, which well-correlated with vulnerability characteristics cap thickness, macrophage recruitment, necrotic core size, thus enabling risk stratification mice complicated pneumonia. successfully identifies excised human artery tissues, promising auxiliary diagnosis clinical application.

Language: Английский

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Flexible and Stretchable Electrochemical Sensors for Biological Monitoring

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 28, 2023

The rise of flexible and stretchable electronics has revolutionized biosensor techniques for probing biological systems. Particularly, electrochemical sensors (FSECSs) enable the in situ quantification numerous biochemical molecules different entities owing to their exceptional sensitivity, fast response, easy miniaturization. Over past decade, fabrication application FSECSs have significantly progressed. This review highlights key developments electrode functionalization. It delves into sensing various biomarkers, including metabolites, electrolytes, signaling molecules, neurotransmitters from systems, encompassing outer epidermis, tissues/organs vitro vivo, living cells. Finally, considering preparation applications, current challenges future opportunities are discussed.

Language: Английский

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Design of a Multifunctional Nanozyme for Resolving the Proinflammatory Plaque Microenvironment and Attenuating Atherosclerosis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14555 - 14571

Published: June 23, 2023

Persistent inflammation within atherosclerotic plaques is a crucial factor contributing to plaque vulnerability and rupture. It has become increasingly evident that the proinflammatory microenvironment of plaque, characterized by heightened monocyte recruitment, oxidative stress, impaired clearance apoptotic cells, plays significant role in perpetuating impeding its resolution. Consequently, targeting eliminating these features have emerged as promising therapeutic approach restore resolution mitigate progression atherosclerosis. While recent advancements nanotherapeutics demonstrated results individual characteristics, development an effective strategy capable simultaneously addressing multiple remains challenge. In this study, we developed multifunctional nanozyme based on Prussian blue, termed PBNZ@PP-Man, target eliminate various factors microenvironment. Through systematic investigations, elucidated antiatherosclerotic mechanisms PBNZ@PP-Man. Our demonstrate PBNZ@PP-Man possesses ability accumulate effectively factors, leading Specifically, suppresses scavenges reactive oxygen species, enhances efferocytosis. Notably, exhibits much stronger efficacy resolve attenuate atherosclerosis comparison merely eliminates one single risky plaque. significantly capabilities macrophages attenuates These collectively underscore importance modulating complementary for resolving

Language: Английский

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Mechanical Stimulation of Anti‐Inflammatory and Antioxidant Hydrogels for Rapid Re‐Epithelialization

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 26, 2024

Abstract The epithelium, an essential barrier to protect organisms against infection, exists in many organs. However, rapid re‐epithelialization restore tissue integrity and function adverse environment is challenging. In this work, a long‐term anti‐inflammatory antioxidant hydrogel with mechanical stimulation for re‐epithelialization, mainly composed of the small molecule thioctic acid, biocompatible glycine, γ‐Fe 2 O 3 nanoparticles reported. Glycine‐modified supramolecular acid stable possesses outstanding properties. incorporating providing potential contrast magnetic resonance imaging observation, can propel reconfiguration enhance properties underwater due water‐initiated release Fe 3+ . vitro experiments show that hydrogels effectively reduced intracellular reactive oxygen species, guided macrophages toward M2 polarization, alleviated inflammation. effect ultimately demonstrated long urethral injury model vivo, achieves effective functional replacement accurate remodeling epithelium. Notably, proposed strategy provides advanced alternative treatment patients need large‐area epithelial reconstruction.

Language: Английский

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Near-Infrared Persistent Luminescence Nanoprobe for Early Detection of Atherosclerotic Plaque

ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6500 - 6512

Published: Feb. 13, 2024

Atherosclerosis (AS) is a crucial contributor to various cardiovascular diseases (CVDs), which seriously threaten human life and health. Early accurate recognition of AS plaques essential for the prevention treatment CVD. Herein, we introduce an AS-targeting nanoprobe based on near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), developing highly sensitive NIR (PersL) plaque imaging technique successfully realizing early detection. The exhibits good monodispersity regular spherical morphology also owns exceptional PersL performance upon repetitive irradiation by biological window light. surface-conjugated antibody (anti-osteopontin) endowed excellent targeting ability foam cells within plaques. After intravenously injected into model mice, can accurately detect prior ultrasonography (US) magnetic resonance (MRI). Specifically, reveals at earliest 2 weeks, with higher signal-to-background ratio (SBR) up 5.72. Based this technique, has great potential applications in CVD, study pathogenesis, screening anti-AS drugs.

Language: Английский

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Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 17, 2024

Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.

Language: Английский

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Detecting mitochondrial hypochlorous acid and viscosity in atherosclerosis models via NIR fluorescent probes

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108191 - 108191

Published: Jan. 20, 2025

Language: Английский

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Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(3)

Published: Nov. 11, 2022

The inflammatory microenvironment involves changes in pH and protein phosphorylation state is closely related to the occurrence development of atherosclerosis (AS). Herein, we constructed a dual-detection fluorescence nanosensor PCN-NP-HPZ based on post modification MOFs, which realized simultaneous detection imaging through pH-sensitive group piperazine ZrIV node MOFs. sensors were used monitor blood phosphate levels at different time stages during atherosclerotic plaque formation. Two-photon was also performed vascular endothelium. Blood tests combined with two-photon images indicated that early stage AS, tissue lower than normal mice, while higher mice. present study provides new analysis method for assessment disease.

Language: Английский

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Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis

Science Advances, Journal Year: 2023, Volume and Issue: 9(41)

Published: Oct. 13, 2023

Oxidative stress is integral in the development of atherosclerosis, but knowledge how oxidative affects atherosclerosis remains insufficient. Here, we design a multiplexed diagnostic tool that includes two functions (photoacoustic imaging and urinalysis), for assessing intraplaque urinary malondialdehyde (MDA), well-recognized end-product stress. Molecular conducted to develop first near-infrared MDA-responsive molecule (MRM). Acid-unlocked ratiometric photoacoustic nanoprobe designed report MDA, enabling it reflect plaque burden. Furthermore, MRM tailored MDA detection with excellent specificity blind study. Moreover, found significant difference between healthy adults atherosclerotic patients (more than 600 participants). Combining these functions, such can dynamically systemic levels during progression, pneumonia infection, drug treatment mice, which promising auxiliary diagnosis atherosclerosis.

Language: Английский

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