ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(12), P. 6824 - 6832
Published: Nov. 27, 2024
Cardiovascular
diseases
(CVDs)
are
a
major
global
health
concern,
highlighting
the
need
for
effective
diagnostic
tools.
Zinc
ions
(Zn2+)
play
role
in
CVDs,
but
their
detection
is
challenging.
This
study
presents
multifunctional
optical
sensor,
HD-Zn,
designed
to
detect
Zn2+
relation
CVDs.
We
developed
novel
fluorescence
probe,
by
conjugating
N,N-di(2-picolyl)ethylenediamine
(DPEN)
HD
via
an
amide
bond,
which
results
quenching
due
photoinduced
electron
transfer
(PeT).
Adding
significantly
increased
intensity
near-infrared
region
(NIR-I).
The
probe
showed
linear
response
varying
concentrations,
with
limit
of
9.8
nM,
appropriate
physiological
conditions.
Fluorescence
imaging
RAW264.7
macrophages
indicated
lower
intracellular
levels
foam
cells
compared
healthy
cells,
linked
CVDsprogression.
In
vivo
mouse
models
decreased
aorta
disease
progression.
Our
findings
confirm
that
HD-Zn
reliable
tool
measuring
plaques
and
demonstrate
its
biosafety
detecting
serum
urine,
offering
potential
clinical
applications
CVDs
diagnosis
monitoring.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101027 - 101027
Published: March 16, 2024
Multimodal
imaging,
which
combines
the
strengths
of
two
or
more
imaging
modalities
to
provide
complementary
anatomical
and
molecular
information,
has
emerged
as
a
robust
technology
for
enhancing
diagnostic
sensitivity
accuracy,
well
improving
treatment
monitoring.
Moreover,
application
multimodal
in
guiding
precision
tumor
can
prevent
under-
over-treatment,
thereby
maximizing
benefits
patients.
In
recent
years,
several
intriguing
magneto-optical
nanosystems
with
both
magnetic
optical
properties
have
been
developed,
leading
significant
breakthroughs
field
image-guided
therapy.
These
advancements
pave
way
precise
medicine.
This
review
summarizes
various
types
developed
recently
describes
their
applications
probes
agents
therapeutic
interventions.
Finally,
future
research
development
prospects
are
discussed
along
an
outlook
on
further
biomedical
field.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(47)
Published: July 31, 2024
Abstract
Near‐infrared
photosensitizers
are
valuable
tools
to
improve
treatment
depth
in
photodynamic
therapy
(PDT).
However,
their
low
singlet
oxygen
(
1
O
2
)
generation
ability,
indicated
by
quantum
yield,
presents
a
formidable
challenge
for
PDT.
To
overcome
this
challenge,
the
heptamethine
cyanine
was
decorated
with
biocompatible
S
Scy7
and
Se
Secy7
atom.
We
observe
that
exhibits
redshift
main
absorption
~840
nm
an
ultra‐efficient
capacity.
The
emergence
of
strong
intramolecular
charge
transfer
effect
between
atom
polymethine
chain
considerably
narrows
energy
gap
(0.51
eV),
heavy
strengthens
spin–orbit
coupling
(1.44
cm
−1
),
both
which
greatly
improved
high
triplet
state
yield
(61
%),
determines
.
Therefore,
demonstrated
excellent
capacity,
is
~24.5‐fold
indocyanine
green,
~8.2‐fold
IR780,
~1.3‐fold
methylene
blue
under
low‐power‐density
850
irradiation
(5
mW
−2
).
considerable
phototoxicity
toward
cancer
cells
buried
12
mm
tissue.
Nanoparticles
formed
encapsulating
within
amphiphilic
polymers
lecithin,
promising
antitumor
anti‐pulmonary
metastatic
effects,
exhibiting
remarkable
potential
advancing
PDT
deep
tissues.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: July 12, 2024
The
research
progress
of
endoplasmic
reticulum
(ER)
stress
in
atherosclerosis
(AS)
is
great
concern.
ER,
a
critical
cellular
organelle,
plays
role
important
biological
processes
including
protein
synthesis,
folding,
and
modification.
Various
pathological
factors
may
cause
ER
stress,
sustained
or
excessive
triggers
the
unfolded
response,
ultimately
resulting
apoptosis
disease.
Recently,
researchers
have
discovered
importance
onset
advancement
AS.
contributes
to
occurrence
AS
through
different
pathways
such
as
apoptosis,
inflammatory
oxidative
autophagy.
Therefore,
this
review
focuses
on
mechanisms
development
related
therapeutic
targets,
which
will
contribute
deeper
understanding
disease's
pathogenesis
provide
novel
strategies
for
preventing
treating
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(2), P. 962 - 970
Published: Jan. 31, 2024
In
this
work,
a
photoacoustic
(PA)
probe,
HDS-GGT,
was
developed
for
the
in
vivo
imaging
of
cardiovascular
diseases
by
monitoring
γ-glutamyl
transferase
(GGT)
dynamics.
HDS-GGT
exhibited
stable
PA
signal
with
auxiliary
absorbance
and
NIRF
variation
after
trigger
GGT.
all
three
modalities
absorbance,
NIRF,
PA,
could
quantitatively
reflect
GGT
level.
modality,
indicated
practical
advantages
including
high
sensitivity,
stability,
specificity.
living
oxidized
low-density
lipoprotein-induced
RAW264.7
cells,
proper
capability
plaques
visualizing
Moreover,
during
model
mice,
achieved
to
distinguish
from
healthy
blood
vessels
via
multiview
presentation.
also
suggest
severity
extracted
aorta
which
consistent
histological
staining
results.
The
information
herein
might
be
useful
future
investigations
on
diseases.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(22), P. 6743 - 6752
Published: May 24, 2024
Lipid
nanoparticles
(LNPs)
represent
the
forefront
of
mRNA
delivery
platforms,
yet
achieving
precise
to
specific
cells
remains
a
challenge.
The
current
targeting
strategies
complicate
formulation
and
impede
regulatory
approval
process.
Here,
through
straightforward
regulation
helper
lipids
within
LNPs,
we
introduce
an
engineered
LNP
designed
for
targeted
into
hepatocytes
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
treatment.
optimized
LNP,
supplied
with
POPC
as
lipid,
exhibits
2.49-fold
increase
in
transfection
efficiency
compared
that
FDA-approved
LNPs.
CTP:phosphocholine
cytidylyltransferase
α
is
selected
system
self-calibration
phosphatidylcholine
levels
prevent
lipid
droplet
expansion
MAFLD.
This
strategy
effectively
regulates
homeostasis,
while
demonstrating
proven
biosafety.
Our
results
present
therapy
MAFLD
open
new
avenue
discovering
potent
enabling
cells.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
The
comprehensive
evaluation
of
tumor
vasculature
that
is
crucial
for
the
development,
expansion,
and
spread
cancer
still
remains
a
great
challenge,
especially
three-dimensional
(3D)
vasculatures.
In
this
study,
we
proposed
magnetic
resonance
(MR)
angiography
strategy
with
interlocking
stratagem
zwitterionic
Gd-chelate
contrast
agents
(PAA-Gd)
continuous
monitoring
angiogenesis
progression
in
3D.
Owing
to
structure
nanoscale
molecular
diameter,
longitudinal
molar
relaxivity
(r1)
PAA-Gd
was
2.5
times
higher
than
individual
Gd-chelates
on
7.0
T
MRI
scanner,
resulting
higher-resolution
visualization
More
importantly,
has
appropriate
blood
half-life
(69.2
min),
emphasizing
extended
imaging
window
compared
Gd-chelates.
On
basis,
by
using
as
agent,
high-resolution,
3D
depiction
spatiotemporal
distribution
microvasculature
solid
tumors
formed
different
cell
lines
over
various
inoculation
been
obtained.
This
method
offers
an
effective
approach
early
diagnosis,
development
assessment,
prognosis
evaluation.
Cell Biology International,
Journal Year:
2024,
Volume and Issue:
48(12), P. 1781 - 1801
Published: Oct. 6, 2024
Atherosclerosis
is
primarily
an
inflammatory
reaction
of
the
cardiovascular
system
caused
by
endothelial
damage,
leading
to
progressive
thickening
and
hardening
vessel
walls,
as
well
extensive
necrosis
fibrosis
surrounding
tissues,
most
necessary
pathological
process
causing
disease.
When
body
responds
harmful
internal
external
stimuli,
excess
oxygen
free
radicals
are
produced
oxidative
stress
occur
in
cells
tissues.
Simultaneously,
activation
immunological
processes
followed
elevation
radicals,
which
directly
initiates
release
cytokines
chemokines,
resulting
a
detrimental
cycle
vascular
homeostasis
abnormalities.
Oxidative
contributes
harm
inflicted
upon
decrease
nitric
oxide
levels.
Nitric
crucial
for
maintaining
implicated
development
atherosclerosis.
This
study
examines
influence
on
formation
atherosclerosis,
facilitated
milieu.
It
also
provides
overview
pertinent
targets
pharmaceutical
approaches
treating
this
condition.