Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)

Published: July 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Language: Английский

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Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

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Magneto-optical nanosystems for tumor multimodal imaging and therapy in-vivo

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101027 - 101027

Published: March 16, 2024

Multimodal imaging, which combines the strengths of two or more imaging modalities to provide complementary anatomical and molecular information, has emerged as a robust technology for enhancing diagnostic sensitivity accuracy, well improving treatment monitoring. Moreover, application multimodal in guiding precision tumor can prevent under- over-treatment, thereby maximizing benefits patients. In recent years, several intriguing magneto-optical nanosystems with both magnetic optical properties have been developed, leading significant breakthroughs field image-guided therapy. These advancements pave way precise medicine. This review summarizes various types developed recently describes their applications probes agents therapeutic interventions. Finally, future research development prospects are discussed along an outlook on further biomedical field.

Language: Английский

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Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

The research progress of endoplasmic reticulum (ER) stress in atherosclerosis (AS) is great concern. ER, a critical cellular organelle, plays role important biological processes including protein synthesis, folding, and modification. Various pathological factors may cause ER stress, sustained or excessive triggers the unfolded response, ultimately resulting apoptosis disease. Recently, researchers have discovered importance onset advancement AS. contributes to occurrence AS through different pathways such as apoptosis, inflammatory oxidative autophagy. Therefore, this review focuses on mechanisms development related therapeutic targets, which will contribute deeper understanding disease's pathogenesis provide novel strategies for preventing treating

Language: Английский

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Measurement of Cellular MDA Content through MTBE-Extraction Based TBA Assay by Eliminating Cellular Interferences

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 248, P. 116332 - 116332

Published: July 1, 2024

Language: Английский

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Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(46)

Published: Aug. 8, 2024

Abstract Atherosclerosis, a major global health concern with high morbidity and mortality rates, involves complex interactions of chronic inflammation, oxidative stress, proteolytic enzymes. Conventional imaging methods struggle to capture the dynamic biochemical processes in atherosclerotic plaques. Here, we introduce novel unimolecular photoacoustic probe (UMAPP) designed specific binding sites for neutrophil elastase (NE) redox pair O 2 ⋅ − /GSH, enabling real‐time monitoring stress activated neutrophils UMAPP, comprising boron‐dipyrromethene (BODIPY) core linked hydrophilic NE‐cleavable tetrapeptide dual stress‐responsive catechol moieties, facilitates NE‐mediated modulation photoinduced electron transfer impacting intensity at 685 nm (PA ). Furthermore, oxidation reduction groups by GSH induce reversible, ratiometric changes spectrum 745 /PA ratio). Initial UMAPP applications successfully distinguished healthy mice, evaluated pneumonia‘s effect on plaque composition verified probe‘s effectiveness drug‐treatment studies detecting molecular alterations before visible histopathological changes. The integrated capabilities offer promising advancements atherosclerosis diagnosis management, early accurate identification vulnerable

Language: Английский

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Helper Lipid-Enhanced mRNA Delivery for Treating Metabolic Dysfunction-Associated Fatty Liver Disease

Nano Letters, Journal Year: 2024, Volume and Issue: 24(22), P. 6743 - 6752

Published: May 24, 2024

Lipid nanoparticles (LNPs) represent the forefront of mRNA delivery platforms, yet achieving precise to specific cells remains a challenge. The current targeting strategies complicate formulation and impede regulatory approval process. Here, through straightforward regulation helper lipids within LNPs, we introduce an engineered LNP designed for targeted into hepatocytes metabolic dysfunction-associated fatty liver disease (MAFLD) treatment. optimized LNP, supplied with POPC as lipid, exhibits 2.49-fold increase in transfection efficiency compared that FDA-approved LNPs. CTP:phosphocholine cytidylyltransferase α is selected system self-calibration phosphatidylcholine levels prevent lipid droplet expansion MAFLD. This strategy effectively regulates homeostasis, while demonstrating proven biosafety. Our results present therapy MAFLD open new avenue discovering potent enabling cells.

Language: Английский

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In Vivo Imaging of γ-Glutamyl Transferase in Cardiovascular Diseases with a Photoacoustic Probe

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(2), P. 962 - 970

Published: Jan. 31, 2024

In this work, a photoacoustic (PA) probe, HDS-GGT, was developed for the in vivo imaging of cardiovascular diseases by monitoring γ-glutamyl transferase (GGT) dynamics. HDS-GGT exhibited stable PA signal with auxiliary absorbance and NIRF variation after trigger GGT. all three modalities absorbance, NIRF, PA, could quantitatively reflect GGT level. modality, indicated practical advantages including high sensitivity, stability, specificity. living oxidized low-density lipoprotein-induced RAW264.7 cells, proper capability plaques visualizing Moreover, during model mice, achieved to distinguish from healthy blood vessels via multiview presentation. also suggest severity extracted aorta which consistent histological staining results. The information herein might be useful future investigations on diseases.

Language: Английский

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High-Resolution Magnetic Resonance Angiography of Tumor Vasculatures with an Interlocking Contrast Agent

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 31, 2024

The comprehensive evaluation of tumor vasculature that is crucial for the development, expansion, and spread cancer still remains a great challenge, especially three-dimensional (3D) vasculatures. In this study, we proposed magnetic resonance (MR) angiography strategy with interlocking stratagem zwitterionic Gd-chelate contrast agents (PAA-Gd) continuous monitoring angiogenesis progression in 3D. Owing to structure nanoscale molecular diameter, longitudinal molar relaxivity (r1) PAA-Gd was 2.5 times higher than individual Gd-chelates on 7.0 T MRI scanner, resulting higher-resolution visualization More importantly, has appropriate blood half-life (69.2 min), emphasizing extended imaging window compared Gd-chelates. On basis, by using as agent, high-resolution, 3D depiction spatiotemporal distribution microvasculature solid tumors formed different cell lines over various inoculation been obtained. This method offers an effective approach early diagnosis, development assessment, prognosis evaluation.

Language: Английский

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Oxidative stress disrupts vascular microenvironmental homeostasis affecting the development of atherosclerosis

Cell Biology International, Journal Year: 2024, Volume and Issue: 48(12), P. 1781 - 1801

Published: Oct. 6, 2024

Atherosclerosis is primarily an inflammatory reaction of the cardiovascular system caused by endothelial damage, leading to progressive thickening and hardening vessel walls, as well extensive necrosis fibrosis surrounding tissues, most necessary pathological process causing disease. When body responds harmful internal external stimuli, excess oxygen free radicals are produced oxidative stress occur in cells tissues. Simultaneously, activation immunological processes followed elevation radicals, which directly initiates release cytokines chemokines, resulting a detrimental cycle vascular homeostasis abnormalities. Oxidative contributes harm inflicted upon decrease nitric oxide levels. Nitric crucial for maintaining implicated development atherosclerosis. This study examines influence on formation atherosclerosis, facilitated milieu. It also provides overview pertinent targets pharmaceutical approaches treating this condition.

Language: Английский

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