Medical imaging-based companion diagnostics for solid tumors DOI Creative Commons
Rui Yin, Qingpeng Zhang,

Shiyi Liao

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100009 - 100009

Published: May 11, 2024

Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), clinical technique that gives doctors vital biomarker information enhance patient outcomes through matching specific treatments patients, is becoming more important. However, most current US Food Drug Administration (FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers because they are used vitro ex vivo. Consequently, new medical imaging-based been widely detect interpatient intrapatient heterogeneity assess intratumoral distribution of variables. They provide stratification for targeted therapies differentiation populations benefit from alternative treatments. This review provides an overview recent advances tumors summarizes various utilized CDx. We believe this offers additional details directions promoting development.

Language: Английский

In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis DOI

Moxuan Ji,

Yongchun Wei,

Zhuo Ye

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(14), P. 10093 - 10102

Published: March 28, 2024

Real-time monitoring of the development atherosclerosis (AS) is key to management cardiovascular disease (CVD). However, existing laboratory approaches lack sensitivity and specificity, mostly due dearth reliable AS biomarkers. Herein, we developed an in vivo fluorescent labeling strategy that allows specific staining foam cell-derived extracellular vesicles (EVs) atherosclerotic plaques, which are released into blood as circulating biomarkers for vitro detection AS. This relies on a self-assembled nanoprobe could recognize cells specifically, where probe degraded by intracellular HClO produce trifluoromethyl-bearing boron-dipyrromethene fluorophore (termed B-CF3), lipophilic dye can be transferred exosomal membranes. These B-CF3-stained EVs detected directly fluorescence spectrometer or microplate reader without resorting any sophisticated analytical method. liquid-biopsy format enables early real-time differentiation lesion vulnerability during progression, facilitating effective CVD management.

Language: Английский

Citations

21
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

20
Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis DOI Creative Commons
Yuan Ma, Wei Sun, Zhifei Ye

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(41)

Published: Oct. 13, 2023

Oxidative stress is integral in the development of atherosclerosis, but knowledge how oxidative affects atherosclerosis remains insufficient. Here, we design a multiplexed diagnostic tool that includes two functions (photoacoustic imaging and urinalysis), for assessing intraplaque urinary malondialdehyde (MDA), well-recognized end-product stress. Molecular conducted to develop first near-infrared MDA-responsive molecule (MRM). Acid-unlocked ratiometric photoacoustic nanoprobe designed report MDA, enabling it reflect plaque burden. Furthermore, MRM tailored MDA detection with excellent specificity blind study. Moreover, found significant difference between healthy adults atherosclerotic patients (more than 600 participants). Combining these functions, such can dynamically systemic levels during progression, pneumonia infection, drug treatment mice, which promising auxiliary diagnosis atherosclerosis.

Language: Английский

Citations

37
Enzyme-activated nanomaterials for MR imaging and tumor therapy DOI

Jingxia Lv,

Renye Yue, Huiyi Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215842 - 215842

Published: April 15, 2024

Language: Английский

Citations

17
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics DOI Creative Commons
Yuting Liu, Ziqi Lin, Yuting Wang

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

Citations

15
Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy DOI Open Access
Wenkai Liu, Shan He,

Xue Ma

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)

Published: July 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Language: Английский

Citations

13
Valence-engineered catalysis-selectivity regulation of molybdenum oxide nanozyme for acute kidney injury therapy and post-cure assessment DOI Creative Commons
Liangyu Li, Xiaotong Liu,

Guanghe Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 8, 2024

The optimization of the enzyme-like catalytic selectivity nanozymes for specific reactive oxygen species (ROS)-related applications is significant, and meanwhile real-time monitoring ROS really crucial tracking therapeutic process. Herein, we present a mild oxidation valence-engineering strategy to modulate valence states Mo in Pluronic F127-coated MoO

Language: Английский

Citations

12
Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics DOI
Rui Wang,

Siwei Hua,

Yanlong Xing

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

Citations

11
Nanorepair medicine for treatment of organ injury DOI Creative Commons
Han Wang,

Jessica C Hsu,

Wenyu Song

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(9)

Published: Aug. 10, 2024

ABSTRACT Organ injuries, such as acute kidney injury, ischemic stroke, and spinal cord often result in complications that can be life-threatening or even fatal. Recently, many nanomaterials have emerged promising agents for repairing various organ injuries. In this review, we present the important developments field of nanomaterial-based repair medicine, herein referred to ‘nanorepair medicine’. We first introduce disease characteristics associated with different types injuries highlight key examples relevant nanorepair medicine. then provide a summary existing strategies including organ-targeting methodologies potential countermeasures against exogenous endogenous pathologic risk factors. Finally, offer our perspectives on current challenges future expectations advancement nanomedicine designed injury repair.

Language: Английский

Citations

11
Magneto-optical nanosystems for tumor multimodal imaging and therapy in-vivo DOI Creative Commons
Mengzhen Wang, Yin Wang, Qinrui Fu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101027 - 101027

Published: March 16, 2024

Multimodal imaging, which combines the strengths of two or more imaging modalities to provide complementary anatomical and molecular information, has emerged as a robust technology for enhancing diagnostic sensitivity accuracy, well improving treatment monitoring. Moreover, application multimodal in guiding precision tumor can prevent under- over-treatment, thereby maximizing benefits patients. In recent years, several intriguing magneto-optical nanosystems with both magnetic optical properties have been developed, leading significant breakthroughs field image-guided therapy. These advancements pave way precise medicine. This review summarizes various types developed recently describes their applications probes agents therapeutic interventions. Finally, future research development prospects are discussed along an outlook on further biomedical field.

Language: Английский

Citations

10