Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF-κB/NLRP3 pathways in inflammatory endothelial cells DOI Creative Commons
Juan Tang, Tao Li,

Xiaojing Xiong

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 30, 2023

Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent causes cardiovascular diseases. However, current treatments often do not adequately compromise inflammation-mediated accumulation and progression. Therefore, new effective strategy that blocks atherosclerosis-associated inflammation urgently needed to further reduce risk. Colchicine, potent anti-inflammatory medication, has shown great potential in treatment atherosclerosis, but its adverse effects have hampered clinical application. Herein, we developed novel delivery nanosystem encapsulated with colchicine (VHPK-PLGA@COL), which exhibited improved biosafety sustained drug release along gradual degradation PLGA PEG as confirmed both vitro vivo. Surface modification nanoparticles VHPK peptide ensured capability specifically target endothelial cells alleviate atherosclerotic accumulation. In ApoE - / mouse model, VHPK-PLGA@COL significantly decreased area enhanced stability blocking NF-κB/NLRP3 pathways, while therapeutic due unique ability without obvious long-term safety concerns. summary, overcome key translational barriers open avenues repurpose this for anti-atherosclerotic therapy.

Language: Английский

Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers DOI Creative Commons

Xiujiao Deng,

Jinghao Wang, Shanshan Yu

et al.

Exploration, Journal Year: 2023, Volume and Issue: 4(3)

Published: Dec. 7, 2023

Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various ligand‐modified nanoparticle systems targeting by specifically signature molecules hope precise treatment at molecular level concludes discussion challenges prospects this field. The intention review is inspire novel concepts design advancement targeted nanomedicines tailored atherosclerosis.

Language: Английский

Citations

25
Pharmacological properties of Polygonatum and its active ingredients for the prevention and treatment of cardiovascular diseases DOI Creative Commons

Hongyuan Lin,

Wenhui Wang,

Mengqi Peng

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 2, 2024

Abstract Despite continued advances in prevention and treatment strategies, cardiovascular diseases (CVDs) remain the leading cause of death worldwide, more effective therapeutic methods are urgently needed. Polygonatum is a traditional Chinese herbal medicine with variety pharmacological applications biological activities, such as antioxidant activity, anti-inflammation, antibacterial effect, immune-enhancing glucose regulation, lipid-lowering anti-atherosclerotic effects, diabetes anticancer effect. There has also been evidence to support cardioprotective effect recent years. However, up now, there lack comprehensive studies on active ingredients their pharmacotoxicological effects related diseases. Therefore, main components (including Polysaccharides, Flavonoids, Saponins) activities were firstly reviewed this paper. Furthermore, we summarized ’s preventing treating CVDs, its relevant toxicological investigations. Finally, emphasize potential CVDs.

Language: Английский

Citations

14
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics DOI Creative Commons
Yuting Liu, Ziqi Lin, Yuting Wang

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

Citations

14
Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques DOI

Yuying Liu,

Zeyu Jiang,

Yang Xiao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: April 2, 2024

Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis

Language: Английский

Citations

13
Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis DOI Open Access

Yang Hong,

Jing Feng,

Zijia Dou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117081 - 117081

Published: July 5, 2024

The discovery of an inhibitor for acyl-CoA synthetase long-chain family member 4 (ACSL4), a protein involved in the process cell injury through ferroptosis, has potential to ameliorate damage. In this study, we aimed investigate berberine (BBR) as ACSL4 order suppress endothelial ferroptosis and provide protection against atherosclerosis. An atherosclerosis model was created ApoE

Language: Английский

Citations

11
Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability DOI Creative Commons

Fanzhen Lv,

Huaqiang Fang, Li Huang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 2, 2024

Abstract Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis treatment atherosclerosis (AS) are crucial for reducing occurrence acute events. However, AS is challenging, oral anti‐AS drugs suffer from limitations like imprecise targeting low bioavailability. To overcome aforementioned shortcomings, Cur/MOF@DS developed, a nanoplatform integrating by loading curcumin (Cur) into metal−organic frameworks with nanozymes magnetic resonance imaging (MRI) properties. In addition, surface‐modification dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within plaque region. This employs mechanisms that scavenge excessive reactive oxygen species microenvironment, promote macrophage autophagy regulate polarization to realize lipid regulation. vivo vitro experiments confirm this outstanding MRI performance effects, which may provide new option AS.

Language: Английский

Citations

9
Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation DOI
Cui Tang, Hui Wang, Lina Guo

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective clearance remains challenging due to the overexpression CD47 molecule on apoptotic cells, inhibiting macrophage-mediated cellular efferocytosis and resolution. Moreover, AS lesions are often associated severe inflammation oxidative stress, exacerbating progression. Herein, we introduce multifunctional nanomedicine (CEZP) targeting pathogenesis via "cell efferocytosis–lipid degradation–cholesterol efflux" paradigm, additional anti-inflammatory properties. CEZP comprises poly(lactic-co-glycolic acid) nanoparticles encapsulated within metal–organic framework shell coordinated zinc ions (Zn2+) epigallocatechin gallate (EGCG), enabling CpG encapsulation. Upon intravenous administration, accumulates at sites, facilitating macrophage uptake orchestrating treatment through synergistic mechanisms. enhances efferocytosis, Zn2+ promotes intracellular lipid degradation, EGCG upregulates adenosine 5′-triphosphate-binding cassette transporters for cholesterol efflux while also exhibiting antioxidant effects. In vivo validation confirms CEZP's ability stabilize plaques, reduce burden, modulate phenotype. excreted from body without safety concerns, offering low-toxicity nonsurgical strategy eradication.

Language: Английский

Citations

1
In Situ Conversion of Atherosclerotic Plaques’ Iron into Nanotheranostics DOI

Wenqi Pan,

Sihui Shao,

Xinyue Cao

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

The presence of a substantial necrotic core in atherosclerotic plaques markedly heightens the risk rupture, consequence elevated iron levels that exacerbate oxidative stress and lipid peroxidation, thereby sustaining detrimental cycle ferroptosis inflammation. Concurrently targeting both inflammation is crucial for effective treatment vulnerable plaques. In this study, we introduce gallium hexacyanoferrate nanoabsorption catalysts (GaHCF NACs) designed to disrupt pathological cycle. GaHCF NACs function as highly efficient chelators with robust antiferroptosis properties. Through situ capture within plaques, these enhance reactive oxygen species scavenging, initiating an amplified therapeutic response. significantly advance plaque regression, stabilization, vascular functional recovery by inhibiting MAPK13 (p38-δ MAPK) signaling, key mediator cell death. Importantly, process generates detectable photoacoustic signal, offering notable diagnostic advantage allows real-time monitoring plague status. This multifunctional nanocatalytic platform transforms toxic into agent, adapting dynamically microenvironment representing promising strategy reducing vulnerability preventing rupture.

Language: Английский

Citations

1
Pitavastatin and resveratrol bio-nanocomplexes against hyperhomocysteinemia-induced atherosclerosis via blocking ferroptosis-related lipid deposition DOI

Anning Yang,

Hongwen Zhang, Huiping Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113598 - 113598

Published: March 1, 2025

Language: Английский

Citations

1
Biomarker‐Responsive Nanosystems for Chronic Disease Theranostics DOI
Qinrui Fu, Leilei Yu, Yin Wang

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(2)

Published: Nov. 23, 2022

Abstract Chronic diseases claim millions of lives every year, and it is great significance to explore develop advanced drugs improve the cure rate chronic diseases. Nanotheranostics are innovative strategies that enable integration diagnostic therapeutic properties into a single nanosystem. Despite success in nanotheranostics, their applications nanotheranostics nanomedicine still infancy. This because each disease has its corresponding characteristic pathological microenvironment, which motivates development endogenous biomarker‐responsive nanosystems meet requirements diagnosis treatment. Herein, recent progress presented biomedical applications. First, classified eight subsections according type diseases, including tumors, cardiovascular neurological Wilson's liver kidney diabetes mellitus, rheumatoid arthritis. In following, variety intriguing biomarkers‐responsive briefly elaborated, such as biosensing, diagnosis, therapy, combined theranostics, early evaluation therapy effect, etc. Finally, challenges future directions from research clinical translation these responsive also presented.

Language: Английский

Citations

32