Purine‐Based Ir(III) Photosensitizers for Efficient Treatment of Periodontal Inflammation DOI Open Access

Ruolin Ding,

Xin Liu, Wenjia Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract Photodynamic therapy (PDT) presents a promising approach for combating periodontitis, an infectious disease triggered by bacteria. However, the hypoxic environment within periodontal pockets poses challenges PDT efficacy. In this study, novel purine‐based C^N ligands are utilized to develop Ir(III) complexes with enhanced reactive oxygen species (ROS) generation capacity periodontitis treatment. The type I/II performance of is greatly purine ligands, which leads potent bactericidal and biofilm elimination rat model local application these effectively achieves antibacterial anti‐inflammatory effects while promoting tissue repair under clinical luminaire exposure. This strategy utilizing circumvents need antibiotics surgical intervention, emerging as promising, non‐invasive managing periodontitis.

Language: Английский

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter DOI Creative Commons
Ximin Cui, Qifeng Ruan, Xiaolu Zhuo

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

Citations

799
Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy DOI Creative Commons
Liang Zhang, An Song,

Qi‐Chao Yang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 2, 2023

Immunogenic programmed cell death, such as pyroptosis and ferroptosis, efficiently induces an acute inflammatory response boosts antitumor immunity. However, the exploration of dual-inducers, particularly nonmetallic inducers, capable triggering both ferroptosis remains limited. Here we show construction a covalent organic framework (COF-919) from planar twisted AIEgen-based motifs dual-inducer for efficient Mechanistic studies reveal that COF-919 displays stronger near-infrared light absorption, lower band energy, longer lifetime to favor generation reactive oxygen species (ROS) photothermal conversion, pyroptosis. Because its good ROS production capability, it upregulates intracellular lipid peroxidation, leading glutathione depletion, low expression peroxidase 4, induction ferroptosis. Additionally, by effectively inhibits tumor metastasis recurrence, resulting in over 90% growth inhibition cure rates exceeding 80%.

Language: Английский

Citations

95
Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment DOI

Yao Xiong,

Yan Rao,

Jiawei Hu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

Citations

85
Metal‐Phenolic Network with Pd Nanoparticle Nodes Synergizes Oxidase‐Like and Photothermal Properties to Eradicate Oral Polymicrobial Biofilm‐Associated Infections DOI
Lei Chen,

Mengna Peng,

Huaping Li

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Nov. 10, 2023

Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) ultrafine size palladium nanoparticles broadband near infrared absorption exhibit excellent oxidase-like activity stable photothermal effect. In vitro experiments demonstrate that the superoxide radical generated SLS-Pd exhibits selective antibacterial effects, while its effect induced hyperthermia potent antifungal properties. This difference further elucidated RNA-sequencing analysis all-atom simulation. Moreover, SLS-Pd-mediated synergistic antimicrobial system remarkable efficacy in combating various biofilms. By establishing root canal model oropharyngeal candidiasis model, feasibility treating biofilm-related infections validated. provides promising therapeutic approach for biofilm-associated cavity.

Language: Английский

Citations

54
Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics DOI
Yingpeng Wan, Weilong Chen,

Ying Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: May 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Language: Английский

Citations

24
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents DOI Creative Commons
Laiping Fang,

Zengzhen Chen,

Jianan Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

Citations

3
Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential DOI Creative Commons
Jiachen Li, Shiqi Wang, Flavia Fontana

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 471 - 507

Published: Dec. 5, 2022

Remarkable progress in phototherapy has been made recent decades, due to its non-invasiveness and instant therapeutic efficacy. In addition, with the rapid development of nanoscience nanotechnology, systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot nanomedicine research, especially cancer. this review, first we briefly introduce history phototherapy, mechanisms cancer treatment. Then, summarize representative over past three five years nanoparticle-based highlight design innovative thereof. Finally, discuss feasibility potential clinical anticancer applications, aiming predict future research directions field. Our review is a tutorial work, at providing useful insights researchers field

Language: Английский

Citations

67
A Facile Structural Isomerization‐Induced 3D Spatial D‐A Interlocked Network for Achieving NIR‐II Phototheranostic Agents DOI
Lina Feng,

Chunbin Li,

Lingxiu Liu

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(50)

Published: Oct. 18, 2022

The performances of second near-infrared (NIR-II) organic phototheranostic agents (OPTAs) depend on both molecular structure and packing when used as nanoparticles (NPs). Herein, we proposed a facile structural isomerization-induced 3D spatial donor (D)-acceptor (A) interlocked network for achieving NIR-II OPTAs. Two isomers, 4MNVDPP 6MNVDPP were synthesized formulated into NPs. 6MNVDPP, which has larger electrostatic potential difference, exhibits compact D-A in the crystal form, while forms 2D D-D type J-aggregates. Thus, NPs show red-shifted NIR absorption molar extinction coefficient than Thanks to typical emission, superior photothermal-stability, high photothermal conversion efficiency (89 %) reactive oxygen species production capacity, exhibit outstanding tiny capillary vasculature/tumor imaging ability synergistic photothermal/photodynamic anti-cancer effect vivo.

Language: Английский

Citations

58
Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection DOI
Wenxiu Xu, Yang Yu, Kai Li

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9415 - 9428

Published: May 3, 2023

Implant-associated infections (IAI) are great challenges to medical healthcare and human wellness, yet current clinical treatments limited the use of antibiotics physical removal infected tissue or implant. Inspired by protein/membrane complex structure its generation reactive oxygen species in mitochondria respiration process immune cells during bacteria invasion, we herein propose a metal/piezoelectric nanostructure embedded on polymer implant surface achieve efficient piezocatalysis for combating IAI. The piezoelectricity-enabled local electron discharge induced oxidative stress generated at implant–bacteria interface can efficiently inhibit activity attachedStaphylococcus aureusby cell membrane disruption sugar energy exhaustion, possess high biocompatibility, eliminate subcutaneous infection simply applying ultrasound stimulation. For further demonstration, treatment root canal reinfection with simplified procedures has been achieved using piezoelectric gutta-percha implanted ex vivo teeth. This surface-confined antibacterial strategy, which takes advantage interspace, easiness processing, noninvasiveness sonodynamic therapy, potential applications IAI treatment.

Language: Английский

Citations

34
Excimer‐Mediated Ultrafast Intermolecular Nonradiative Decay Enables Giant Photothermal Performance for Optimized Phototheranostic DOI

Xiaofei Miao,

Weiyun Yao, Ruizhe Chen

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(30)

Published: May 4, 2023

Developing organic photothermal materials (OPMs) with high performance for phototheranostic mainly focus on the manipulation of intramolecular nonradiative (intraNR) decay, which often requires quite complicated and time-consuming molecular engineering. In addition to intraNR intermolecular (interNR) decay is equally important more convenient in governing performance. However, controlling interNR remains challenging due limited understanding their origin dynamics. Here, systemic investigation directs first demonstration simple produce a giant optimized phototheranostic. Among three designed polymers varying fluorine substitution, structure-performance studies reveal dimer-initiated improve Dimer formed by CF···H hydrogen bond. This finding inspires aggregation control strategy form excited dimer, namely, excimer. It initiates an ≈100-fold enhancement rate over conventional ultrahigh conversion efficiency 81% efficient photoacoustic imaging-guided therapy vivo. study provides insights into achieving effect paves way develop high-performance OPMs.

Language: Английский

Citations

24