Purine‐Based Ir(III) Photosensitizers for Efficient Treatment of Periodontal Inflammation DOI Open Access

Ruolin Ding,

Xin Liu, Wenjia Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 16, 2024

Abstract Photodynamic therapy (PDT) presents a promising approach for combating periodontitis, an infectious disease triggered by bacteria. However, the hypoxic environment within periodontal pockets poses challenges PDT efficacy. In this study, novel purine‐based C^N ligands are utilized to develop Ir(III) complexes with enhanced reactive oxygen species (ROS) generation capacity periodontitis treatment. The type I/II performance of is greatly purine ligands, which leads potent bactericidal and biofilm elimination rat model local application these effectively achieves antibacterial anti‐inflammatory effects while promoting tissue repair under clinical luminaire exposure. This strategy utilizing circumvents need antibiotics surgical intervention, emerging as promising, non‐invasive managing periodontitis.

Language: Английский

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways DOI
Heqi Gao, Yiming Yao, Cong Li

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(17)

Published: March 6, 2024

Abstract The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective absorption uncontrollable excited‐state energy decay pathways often result in insufficient theranostic outcomes. Herein a nano‐agent (PS‐1 NPs) based on azulenyl squaraine derivatives with strong band centered at 1092 nm is reported, allowing almost all absorbed excitation dissipate through non‐radiative pathways, leading high photothermal conversion efficiency (90.98 %) photoacoustic response. Both vitro vivo photoacoustic/photothermal therapy results demonstrate deep cancer performance PS‐1 NPs. Even 5 mm deep‐seated tumor model, NPs demonstrated satisfactory anti‐tumor effect imaging‐guided therapy. Moreover, human extracted tooth root canal infection synergistic outcomes 0.5 % NaClO solution resulted therapeutic efficacy comparable clinical gold standard irrigation agent 5.25 NaClO, opening up possibilities expansion agents oral medicine.

Language: Английский

Citations

12
A Cyanine with 83.2% Photothermal Conversion Efficiency and Absorption Wavelengths over 1200 nm for Photothermal Therapy DOI
Liang Zhao, Han Zhu,

You‐Yang Duo

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: May 23, 2024

Abstract Developing small‐molecule photothermal agents (PTAs) with good near‐infrared‐II (NIR‐II) response for deeper tissue penetration and minimizing damage to healthy tissues has attracted much attention in therapy (PTT). However, concentrating ultra‐long excitation wavelengths high conversion efficiencies (PCEs) into a single organic small molecule is still challenging due the lack of suitable molecular structures. Here, six polymethine cyanine molecules based on structure indocyanine green are synthesized by increasing conjugated two‐terminal indole salts number rigid methine units, incorporating longer alkyl side chains salts. Ultimately, IC‐1224 obtained an absorption wavelength more than 1200 nm, which PCE up 83.2% NIR‐II window exhibits excellent PTT tumor ablation performance. This provides high‐performance NIR‐II‐responsive PTA, offers further possibilities application biomedical fields.

Language: Английский

Citations

10
A novel exosome-based multifunctional nanocomposite platform driven by photothermal-controlled release system for repair of skin injury DOI
Xu Teng, Tao Liu, Guifang Zhao

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 258 - 272

Published: May 31, 2024

Language: Английский

Citations

10
Phototherapy: progress, challenges, and opportunities DOI
Xi Yuan,

Junliang Zhou,

Lin Yuan

et al.

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

Citations

10
Advancing Efficiency in Solar-Driven Interfacial Evaporation: Strategies and Applications DOI
Lanlan Hou, Shuai Li,

Yingqun Qi

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Solar-driven interfacial evaporation (SDIE) has emerged as a promising technology for addressing global water scarcity by utilizing solar-thermal conversion and at the air/material/water interface. The exceptional performance of these systems attracted significant interest; it is imperative to establish rigorous scientific standards evaluating effectiveness, optimizing system design, ensuring efficient practical applications. In this Review, we propose consensus criteria accurately assessing guiding future advancements. We then explore fundamental mechanisms driving synergy, emphasizing how material compositions, microscopic hierarchical structures, macroscopic three-dimensional spatial architecture designs enhance solar absorption photothermal conversion; balance heat confinement with pathway optimization; manage salt resistance; regulate enthalpy during vaporization. These matched coordination strategies are crucial maximizing target SDIE efficiency. Additionally, investigate applications technologies, focusing on cutting-edge progress versatile purification, combined atmospheric harvesting, collection, electric generation, deicing. Finally, highlight challenges exciting opportunities advancing research, efforts integrate principles, system-level collaboration, application-driven approaches boost sustainable highly energy technologies. By linking evaluation optimization influencing factors, offer comprehensive overview field outlook that promotes clean production synergistic

Language: Английский

Citations

1
Near‐Infrared Light‐Driving Organic Photothermal Agents with an 88.9% Photothermal Conversion Efficiency for Image‐Guided Synergistic Phototherapy DOI
Xilin Zhao, Mengxin Sun,

Cao Xiaohan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: March 23, 2024

Photothermal agents (PTAs) with desirable near-infrared (NIR) absorption and excellent photothermal conversion efficiency (PCE) are ideal candidates for cancer treatment. However, numerous PTAs still require high-intensity long-duration laser irradiation to completely ablate the tumor during therapy (PTT) process, resulting in light damage healthy skin tissue as well limiting their biomedical applications. Integrating intense NIR high PCE into a single small-molecule PTA is an important prerequisite realizing efficient PTT, but serious challenge. Herein, series of donor-acceptor type (CC1 NC4) designed through molecular engineering strategy. Theoretical calculations experimental results show that effect from CC1 NC4 significantly enhanced expected. Notably, nanoparticles exhibit absorption, superhigh up 88.9% photoacoustic imaging imaging, effective reactive oxygen species generation photodynamic (PDT). The superior PTT/PDT synergistic phototherapeutic efficacy demonstrated by complete elimination vivo upon one-time, low-intensity, short-duration (808 nm, 330 mW cm

Language: Английский

Citations

6
Biomedical applications and prospects of temperature‐orchestrated photothermal therapy DOI Creative Commons
Nuo Xu, Xu Zhang, Tingting Qi

et al.

MedComm – Biomaterials and Applications, Journal Year: 2022, Volume and Issue: 1(2)

Published: Sept. 1, 2022

Abstract Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and lower invasive burden. Since the photothermal killing cells/bacteria showed different patterns death depending on varying temperature in PTT, change PTT is vital to cell/tissue response scientific research clinical application. On one hand, mild received substantial attention treatment cancer soft/hard tissue repair. other induced by capable antibacterial capacity, which better than conventional antibiotic with drug resistance. Herein, we summarize recent developments application temperature‐dependent biomaterials, mainly covering ranges 40–42°C, 43–50°C, over 50°C. We highlight biological mechanism latest progress diseases. Finally, conclude discussing challenges perspectives biomaterials addressing temperature‐orchestrated PTT. Given deep understanding interaction between biology, rationally designed sophisticated responsiveness will benefit outcomes personalized toward various

Language: Английский

Citations

27
Enhancement approaches for photothermal conversion of donor–acceptor conjugated polymer for photothermal therapy: a review DOI Creative Commons

Thi-Thuy Duong Pham,

Le Minh Tu Phan, Sungbo Cho

et al.

Science and Technology of Advanced Materials, Journal Year: 2022, Volume and Issue: 23(1), P. 707 - 734

Published: Oct. 13, 2022

Conjugated polymer (CP)-based photothermal materials have been widely acknowledged as a promising class of agents for biomedical applications. This is because their light-harvesting ability, conversion efficiency, photostability, and favorable biocompatibility. Donor–acceptor (D–A) CPs, which are based on the evolution attracted considerable interest in this field tunable absorption near-infrared biological window. property enables deep penetration into cancer sites, improving efficiency anti-cancer treatment. review mainly focuses potential D–A CP to achieve improved efficient conversion, exploring its optimized advantages therapy Based general insight provided by Jablonski diagram, mechanism related principles activating CPs proposed discussed. provides an overall understanding correlation between molecular nanomaterials heat generation. presents details methodologies rational design nanoparticles with thus facilitating use diagnostic therapeutic

Language: Английский

Citations

26
Conjugated Polymer Nanoparticles for Tumor Theranostics DOI
Tianyu Li, Mengqi Wu,

Qidong Wei

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(5), P. 1943 - 1979

Published: April 21, 2023

Water-dispersible conjugated polymer nanoparticles (CPNs) have demonstrated great capabilities in biological applications, such as vitro cell/subcellular imaging and biosensing, or vivo tissue disease treatment. In this review, we summarized the recent advances of CPNs used for tumor treatment during past five years. with different structures, which been applied to solid (fluorescence, photoacoustic, dual-modal) (phototherapy, drug carriers, synergistic therapy), are discussed detail. We also potential cancer theranostic nanoplatforms. Finally, current challenges outlooks field.

Language: Английский

Citations

15
Diradical‐Featured Organic Small‐Molecule Photothermal Material Based on 4,6‐di(2‐thienyl)thieno[3,4‐c][1,2,5]thiadiazole for Photothermal Immunotherapy DOI
Chunyu Yang, Lixin Guo, Kaixin Zhang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(52)

Published: Sept. 11, 2023

Abstract Photothermal immunotherapy can provide an efficient and convenient strategy for cancer treatment by inducing immunogenic cell death (ICD) to generate vaccine‐like functions in situ, which highly relies on suitable photothermal agents with superior effect. Herein, a novel diradical‐featured organic small‐molecule material (TTD‐TPE) based 4,6‐di(2‐thienyl)thieno[3,4‐c][1,2,5]thiadiazole tetraphenylethylene is developed exhibit near‐infrared (NIR) absorption of 808 nm, high conversion efficiency (PTCE) about 75%, photoacoustic imaging (PAI) property nanoparticle. The excellent effect TTD‐TPE nanoparticles originates from the integrated synergic D–A interactions, diradical character, excited‐state intramolecular motion, not only ablates primary tumor localized temperature but also transforms into vaccine situ through ICD inhibit growth distant metastatic tumors, demonstrating huge potential immunotherapy. Thus, this finding encourage researchers develop materials boost simple useful modality treatment.

Language: Английский

Citations

15